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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DCN

Summary for DCN

Gene information	Gene symbol	DCN
	Ensembl ID	ENSG00000011465
	Entrez ID	1634
	Gene name	decorin
	Synonyms	DSPG2\|SLRR1B
	Gene type	protein_coding
	UniProtAcc	P07585

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Dataset with differentially expressed gene: DCN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.311742	3.03e-10

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Expression of DCN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DCN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DCN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DCN	hsa-miR-5011-5p	100	NM_001920
DCN	hsa-miR-190a-3p	99.9843	NM_001920
DCN	hsa-miR-4262	94.0914	NM_133507
DCN	hsa-miR-3908	93.0843	NM_133507
DCN	hsa-miR-642a-3p	92.3601	NM_133507
DCN	hsa-miR-642b-3p	92.3601	NM_133507
DCN	hsa-miR-5006-5p	91.5586	NM_001920
DCN	hsa-miR-3145-5p	90.1151	NM_001920
DCN	hsa-miR-150-3p	89.8427	NM_001920
DCN	hsa-miR-4766-3p	89.7565	NM_133507
DCN	hsa-miR-3606-5p	88.9278	NM_001920
DCN	hsa-miR-181b-5p	86.9897	NM_133507
DCN	hsa-miR-181d-5p	86.9897	NM_133507
DCN	hsa-miR-181a-5p	86.9897	NM_133507
DCN	hsa-miR-181c-5p	86.9897	NM_133507
DCN	hsa-miR-4288	86.9204	NM_001920
DCN	hsa-miR-6124	86.4785	NM_001920
DCN	hsa-miR-4724-5p	86.2313	NM_001920
DCN	hsa-miR-340-5p	85.8733	NM_001920
DCN	hsa-miR-208b-5p	85.4123	NM_001920
DCN	hsa-miR-208a-5p	85.4123	NM_001920
DCN	hsa-miR-107	84.9138	NM_001920
DCN	hsa-miR-103a-3p	84.9138	NM_001920
DCN	hsa-miR-4275	84.4007	NM_133507
DCN	hsa-miR-623	83.9079	NM_001920
DCN	hsa-miR-6867-5p	82.4136	NM_001920
DCN	hsa-miR-5006-3p	82.2534	NM_001920
DCN	hsa-miR-4755-5p	82.2534	NM_001920
DCN	hsa-miR-6806-5p	82.1829	NM_001920
DCN	hsa-miR-4722-5p	81.8807	NM_001920
DCN	hsa-miR-374b-3p	81.2165	NM_001920
DCN	hsa-miR-491-3p	81.2097	NM_001920
DCN	hsa-miR-541-3p	81.017	NM_133507
DCN	hsa-miR-654-5p	81.017	NM_133507
DCN	hsa-miR-875-3p	80.5601	NM_001920
DCN	hsa-miR-203a-3p	80.2036	NM_001920

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Motifs and transcription factors (TFs) regulating DCN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."