Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DCLRE1C

Summary for DCLRE1C

Gene information	Gene symbol	DCLRE1C
	Ensembl ID	ENSG00000152457
	Entrez ID	64421
	Gene name	DNA cross-link repair 1C
	Synonyms	A-SCID\|ARTEMIS\|FLJ11360\|SCIDA\|SNM1C
	Gene type	protein_coding
	UniProtAcc	Q96SD1

Top

Dataset with differentially expressed gene: DCLRE1C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.369619	0.00e+00

Top

Expression of DCLRE1C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to DCLRE1C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating DCLRE1C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DCLRE1C	hsa-miR-511-5p	95.0474	NM_001033858
DCLRE1C	hsa-miR-6809-3p	93.3099	NM_001033858
DCLRE1C	hsa-miR-548p	90.0426	NM_001033855
DCLRE1C	hsa-miR-1468-3p	89.2548	NM_001033855
DCLRE1C	hsa-miR-450b-3p	85.43	NM_001033858
DCLRE1C	hsa-miR-4518	83.765	NM_001033855
DCLRE1C	hsa-miR-1266-5p	83.765	NM_001033855
DCLRE1C	hsa-miR-6857-5p	82.7356	NM_001033858
DCLRE1C	hsa-miR-769-3p	82.3749	NM_001033858
DCLRE1C	hsa-miR-7151-3p	82.247	NM_001033858
DCLRE1C	hsa-miR-4705	82.0244	NM_001033858
DCLRE1C	hsa-miR-380-3p	81.6363	NM_001033858
DCLRE1C	hsa-miR-8066	80.8893	NM_001033858
DCLRE1C	hsa-miR-4519	80.8131	NM_001033858
DCLRE1C	hsa-miR-9983-3p	80.7814	NM_001033858
DCLRE1C	hsa-miR-4652-3p	80.6882	NM_001033858

Page: 1

Top

Motifs and transcription factors (TFs) regulating DCLRE1C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."