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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DCAF6

Summary for DCAF6

Gene information	Gene symbol	DCAF6
	Ensembl ID	ENSG00000143164
	Entrez ID	55827
	Gene name	DDB1 and CUL4 associated factor 6
	Synonyms	IQWD1\|PC326
	Gene type	protein_coding
	UniProtAcc	Q58WW2

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Dataset with differentially expressed gene: DCAF6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.525181	1.87e-39
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.266036	0.00e+00

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Expression of DCAF6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DCAF6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DCAF6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DCAF6	hsa-miR-32-5p	97.8277	NM_001017977
DCAF6	hsa-miR-92b-3p	97.8277	NM_001017977
DCAF6	hsa-miR-92a-3p	97.8277	NM_001017977
DCAF6	hsa-miR-363-3p	97.3341	NM_001017977
DCAF6	hsa-miR-25-3p	97.3341	NM_001017977
DCAF6	hsa-miR-367-3p	97.3341	NM_001017977
DCAF6	hsa-miR-532-3p	96.0157	NM_001017977
DCAF6	hsa-let-7a-3p	95.8628	NM_001017977
DCAF6	hsa-let-7b-3p	95.8628	NM_001017977
DCAF6	hsa-miR-98-3p	95.8628	NM_001017977
DCAF6	hsa-let-7f-1-3p	95.8628	NM_001017977
DCAF6	hsa-miR-5584-5p	95.745	NM_001198957
DCAF6	hsa-miR-4325	95.5395	NM_001017977
DCAF6	hsa-miR-589-3p	94.5562	NM_001198957
DCAF6	hsa-miR-4280	93.4947	NM_001198957
DCAF6	hsa-miR-150-5p	92.5868	NM_001198957
DCAF6	hsa-miR-676-5p	92.1428	NM_001198957
DCAF6	hsa-miR-381-3p	92.0958	NM_001017977
DCAF6	hsa-miR-300	92.0958	NM_001017977
DCAF6	hsa-miR-4327	91.9524	NM_001017977
DCAF6	hsa-miR-4733-5p	91.7333	NM_001198957
DCAF6	hsa-miR-4666a-3p	90.1548	NM_001017977
DCAF6	hsa-miR-5197-5p	89.7163	NM_001198957
DCAF6	hsa-miR-302a-3p	89.5433	NM_001017977
DCAF6	hsa-miR-302b-3p	89.5433	NM_001017977
DCAF6	hsa-miR-302c-3p	89.5433	NM_001017977
DCAF6	hsa-miR-302d-3p	89.5433	NM_001017977
DCAF6	hsa-miR-302e	89.5433	NM_001017977
DCAF6	hsa-miR-520b-3p	87.8873	NM_001017977
DCAF6	hsa-miR-372-3p	87.8873	NM_001017977
DCAF6	hsa-miR-520a-3p	87.8873	NM_001017977
DCAF6	hsa-miR-520d-3p	87.8873	NM_001017977
DCAF6	hsa-miR-520c-3p	87.8873	NM_001017977
DCAF6	hsa-miR-520e-3p	87.8873	NM_001017977
DCAF6	hsa-miR-373-3p	87.8873	NM_001017977
DCAF6	hsa-miR-640	86.9516	NM_001017977
DCAF6	hsa-miR-636	86.6327	NM_001017977
DCAF6	hsa-miR-7703	85.7875	NM_001017977
DCAF6	hsa-miR-154-5p	85.0721	NM_001198957
DCAF6	hsa-miR-1272	84.4037	NM_001198957
DCAF6	hsa-miR-5680	82.5939	NM_001017977
DCAF6	hsa-miR-4713-5p	81.0998	NM_001198957
DCAF6	hsa-miR-520f-3p	80.8375	NM_001017977

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Motifs and transcription factors (TFs) regulating DCAF6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DCAF6	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
DCAF6	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
DCAF6	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
DCAF6	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
DCAF6	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
DCAF6	hdpi__TP73	TP73 (directAnnotation).
DCAF6	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."