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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DCAF5

Summary for DCAF5

Gene information	Gene symbol	DCAF5
	Ensembl ID	ENSG00000139990
	Entrez ID	8816
	Gene name	DDB1 and CUL4 associated factor 5
	Synonyms	BCRG2\|BCRP2\|D14S1461E\|KIAA1824\|WDR22
	Gene type	protein_coding
	UniProtAcc	Q96JK2

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Dataset with differentially expressed gene: DCAF5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.350279	1.73e-35

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Expression of DCAF5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DCAF5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DCAF5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DCAF5	hsa-miR-3065-5p	99.4914	NM_001284208
DCAF5	hsa-miR-7159-5p	98.6073	NM_001284208
DCAF5	hsa-miR-6780a-3p	94.4812	NM_001284207
DCAF5	hsa-miR-4801	93.5251	NM_001284207
DCAF5	hsa-miR-3059-5p	92.1093	NM_001284207
DCAF5	hsa-miR-6809-3p	92.0311	NM_001284207
DCAF5	hsa-miR-4731-3p	91.4859	NM_001284207
DCAF5	hsa-miR-636	90.7704	NM_001284208
DCAF5	hsa-miR-7158-5p	90.647	NM_001284207
DCAF5	hsa-miR-580-3p	90.2232	NM_001284208
DCAF5	hsa-miR-448	89.7231	NM_001284207
DCAF5	hsa-miR-6781-3p	89.7154	NM_001284208
DCAF5	hsa-miR-5001-3p	89.1712	NM_001284207
DCAF5	hsa-miR-3680-3p	88.1976	NM_001284206
DCAF5	hsa-miR-3121-3p	87.8128	NM_001284207
DCAF5	hsa-miR-2682-3p	87.5111	NM_001284208
DCAF5	hsa-miR-503-3p	87.2503	NM_001284207
DCAF5	hsa-miR-26b-3p	87.077	NM_001284208
DCAF5	hsa-miR-95-5p	86.2506	NM_001284207
DCAF5	hsa-miR-129-5p	86.1307	NM_001284207
DCAF5	hsa-miR-9983-3p	86.0008	NM_001284207
DCAF5	hsa-miR-4493	84.7023	NM_001284208
DCAF5	hsa-miR-6081	84.3373	NM_001284206
DCAF5	hsa-miR-4703-5p	83.8549	NM_001284208
DCAF5	hsa-miR-618	83.6634	NM_001284208
DCAF5	hsa-miR-421	83.5143	NM_001284208
DCAF5	hsa-miR-4762-5p	83.4727	NM_001284208
DCAF5	hsa-miR-4750-3p	82.5379	NM_001284208
DCAF5	hsa-miR-4781-3p	82.2089	NM_001284207
DCAF5	hsa-miR-455-5p	82.0183	NM_001284207
DCAF5	hsa-miR-499a-5p	81.9557	NM_001284208
DCAF5	hsa-miR-2114-5p	81.8893	NM_001284208
DCAF5	hsa-miR-190a-3p	80.6956	NM_001284208
DCAF5	hsa-miR-7111-3p	80.6906	NM_001284207
DCAF5	hsa-miR-6827-5p	80.2731	NM_001284207

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Motifs and transcription factors (TFs) regulating DCAF5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DCAF5	metacluster_135.11	NR2C2 (directAnnotation).
DCAF5	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
DCAF5	tfdimers__MD00038	TFAP2C (directAnnotation).
DCAF5	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
DCAF5	metacluster_7.13	ZFX (directAnnotation).
DCAF5	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
DCAF5	cisbp__M00968	MTF2 (directAnnotation).
DCAF5	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
DCAF5	metacluster_160.20	JUND; PRDM15 (directAnnotation).
DCAF5	cisbp__M00341	PAX6 (directAnnotation).
DCAF5	metacluster_198.3	ZFP64 (directAnnotation).
DCAF5	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
DCAF5	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
DCAF5	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
DCAF5	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
DCAF5	cisbp__M00788	ZFY (inferredBy_Orthology).
DCAF5	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
DCAF5	metacluster_175.1	ZNF283 (directAnnotation).
DCAF5	hdpi__ZNF304	ZNF304 (directAnnotation).
DCAF5	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
DCAF5	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
DCAF5	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
DCAF5	transfac_pro__M01199	TRIM28 (directAnnotation).
DCAF5	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
DCAF5	metacluster_151.2	ZNF23 (directAnnotation).
DCAF5	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DCAF5	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
DCAF5	transfac_pro__M03806	ZBTB7C (directAnnotation).
DCAF5	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."