Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DBNDD2

Summary for DBNDD2

Gene information	Gene symbol	DBNDD2
	Ensembl ID	ENSG00000244274
	Entrez ID	55861
	Gene name	dysbindin domain containing 2
	Synonyms	C20orf35\|HSMNP1
	Gene type	protein_coding
	UniProtAcc	Q9BQY9

Top

Dataset with differentially expressed gene: DBNDD2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.38867	2.41e-31

Top

Expression of DBNDD2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to DBNDD2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating DBNDD2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DBNDD2	hsa-miR-4795-3p	99.8138	NM_001048226
DBNDD2	hsa-miR-126-5p	99.2105	NM_001048226
DBNDD2	hsa-miR-6165	93.1972	NM_001048226
DBNDD2	hsa-miR-11181-3p	92.0289	NM_001048226
DBNDD2	hsa-miR-765	91.3772	NM_001048226
DBNDD2	hsa-miR-3614-5p	90.8298	NM_001048226
DBNDD2	hsa-miR-4728-5p	88.431	NM_001197140
DBNDD2	hsa-miR-374b-3p	87.6377	NM_001048226
DBNDD2	hsa-miR-5699-3p	87.3063	NM_001048226
DBNDD2	hsa-miR-1224-3p	87.1327	NM_001048226
DBNDD2	hsa-miR-4722-5p	86.2423	NM_001197140
DBNDD2	hsa-miR-3619-5p	85.3818	NM_001048226
DBNDD2	hsa-miR-214-3p	85.3818	NM_001048226
DBNDD2	hsa-miR-4691-5p	84.4353	NM_001048226
DBNDD2	hsa-miR-4421	83.4521	NM_001048226
DBNDD2	hsa-miR-622	83.2105	NM_001048226
DBNDD2	hsa-miR-4456	81.2678	NM_001197140
DBNDD2	hsa-miR-6785-5p	80.4445	NM_001197140
DBNDD2	hsa-miR-1260b	80.3164	NM_001048226
DBNDD2	hsa-miR-1260a	80.3164	NM_001048226
DBNDD2	hsa-miR-6792-3p	80.2423	NM_001048226

Page: 1

Top

Motifs and transcription factors (TFs) regulating DBNDD2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."