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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DAB2

Summary for DAB2

Gene information	Gene symbol	DAB2
	Ensembl ID	ENSG00000153071
	Entrez ID	1601
	Gene name	DAB adaptor protein 2
	Synonyms	DOC-2
	Gene type	protein_coding
	UniProtAcc	P98082

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Dataset with differentially expressed gene: DAB2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.31621	2.11e-08
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.691152	2.42e-13
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.55638	2.60e-15
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.340012	1.55e-28
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.280165	1.24e-09
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.657377	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.48592	0.00e+00

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Expression of DAB2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DAB2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DAB2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DAB2	hsa-miR-5195-3p	99.635	NM_001244871
DAB2	hsa-miR-145-5p	99.635	NM_001244871
DAB2	hsa-miR-6857-3p	96.7014	NM_001244871
DAB2	hsa-miR-3925-3p	94.2527	NM_001244871
DAB2	hsa-miR-4474-3p	93.8278	NM_001244871
DAB2	hsa-miR-6878-5p	93.1392	NM_001244871
DAB2	hsa-miR-4520-2-3p	92.2953	NM_001244871
DAB2	hsa-miR-208b-5p	91.8562	NM_001244871
DAB2	hsa-miR-208a-5p	91.8562	NM_001244871
DAB2	hsa-miR-4489	91.5654	NM_001244871
DAB2	hsa-miR-498-3p	91.0679	NM_001244871
DAB2	hsa-miR-17-5p	90.9577	NM_001244871
DAB2	hsa-miR-106b-5p	90.9577	NM_001244871
DAB2	hsa-miR-20a-5p	90.9577	NM_001244871
DAB2	hsa-miR-93-5p	90.9577	NM_001244871
DAB2	hsa-miR-20b-5p	90.9577	NM_001244871
DAB2	hsa-miR-106a-5p	90.9577	NM_001244871
DAB2	hsa-miR-526b-3p	90.9577	NM_001244871
DAB2	hsa-miR-519d-3p	90.9577	NM_001244871
DAB2	hsa-miR-644a	90.7107	NM_001244871
DAB2	hsa-miR-7850-5p	90.6533	NM_001244871
DAB2	hsa-miR-1273h-3p	89.8676	NM_001244871
DAB2	hsa-miR-3680-3p	89.3081	NM_001244871
DAB2	hsa-miR-498-5p	88.8182	NM_001244871
DAB2	hsa-miR-585-5p	87.7795	NM_001244871
DAB2	hsa-miR-3166	86.3093	NM_001244871
DAB2	hsa-let-7c-3p	85.5952	NM_001244871
DAB2	hsa-miR-451b	84.9137	NM_001244871
DAB2	hsa-miR-5689	84.267	NM_001244871
DAB2	hsa-miR-6855-3p	83.9411	NM_001244871
DAB2	hsa-miR-4513	83.9411	NM_001244871
DAB2	hsa-miR-6509-5p	83.7636	NM_001244871
DAB2	hsa-miR-4784	83.755	NM_001244871
DAB2	hsa-miR-3150b-3p	83.755	NM_001244871
DAB2	hsa-miR-2115-3p	83.5198	NM_001244871
DAB2	hsa-miR-331-5p	83.4141	NM_001244871
DAB2	hsa-miR-320e	83.3372	NM_001244871
DAB2	hsa-miR-30c-2-3p	82.964	NM_001244871
DAB2	hsa-miR-6788-5p	82.964	NM_001244871
DAB2	hsa-miR-30c-1-3p	82.964	NM_001244871
DAB2	hsa-miR-4439	82.6827	NM_001244871
DAB2	hsa-miR-3136-5p	81.9116	NM_001244871
DAB2	hsa-miR-203a-3p	80.3709	NM_001244871
DAB2	hsa-miR-5696	80.108	NM_001244871

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Motifs and transcription factors (TFs) regulating DAB2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DAB2	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
DAB2	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
DAB2	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
DAB2	transfac_pro__M06156	ZNF75D (directAnnotation).
DAB2	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
DAB2	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
DAB2	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
DAB2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
DAB2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
DAB2	transfac_pro__M04617	ZBTB7A (directAnnotation).
DAB2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
DAB2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
DAB2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
DAB2	transfac_pro__M07387	ZBTB7A (directAnnotation).
DAB2	transfac_pro__M07436	WT1 (directAnnotation).
DAB2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
DAB2	transfac_pro__M00716	ZBTB14 (directAnnotation).
DAB2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
DAB2	hdpi__HIP2	UBE2K (directAnnotation).
DAB2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
DAB2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
DAB2	transfac_pro__M04893	TAF1 (directAnnotation).
DAB2	transfac_pro__M03876	ZBTB33 (directAnnotation).
DAB2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
DAB2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
DAB2	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
DAB2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
DAB2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
DAB2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
DAB2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
DAB2	cisbp__M00968	MTF2 (directAnnotation).
DAB2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
DAB2	cisbp__M00341	PAX6 (directAnnotation).
DAB2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
DAB2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
DAB2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
DAB2	transfac_pro__M01199	TRIM28 (directAnnotation).
DAB2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DAB2	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
DAB2	jaspar__MA1708.1	ETV7 (directAnnotation).
DAB2	swissregulon__hs__ELK1	ELK1 (directAnnotation).
DAB2	metacluster_183.4	ETS1 (inferredBy_Orthology).
DAB2	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
DAB2	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
DAB2	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
DAB2	metacluster_81.7	CREB1 (directAnnotation).
DAB2	transfac_pro__M01298	MECP2 (directAnnotation).
DAB2	transfac_pro__M06795	ZNF780B (directAnnotation).
DAB2	transfac_pro__M05636	ZNF134; ZNF154; ZNF256; ZNF304; ZNF418; ZNF419; ZNF480; ZNF548; ZNF549; ZNF552; ZNF561; ZNF562; ZNF584; ZNF586; ZNF587B; ZNF610; ZNF772; ZNF773; ZNF792; ZNF793; ZNF837 (inferredBy_Orthology).
DAB2	transfac_pro__M01266	ELF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."