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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CYREN

Summary for CYREN

Gene information	Gene symbol	CYREN
	Ensembl ID	ENSG00000122783
	Entrez ID	78996
	Gene name	cell cycle regulator of NHEJ
	Synonyms	C7orf49\|FLJ22450\|FLJ27285\|MGC5242\|MRI\|MRI-2
	Gene type	protein_coding
	UniProtAcc	Q9BWK5

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Dataset with differentially expressed gene: CYREN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.270824	0.00e+00

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Expression of CYREN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CYREN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CYREN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CYREN	hsa-miR-449a	94.9306	NM_001243755
CYREN	hsa-miR-34a-5p	94.9306	NM_001243755
CYREN	hsa-miR-3646	94.8762	NM_001305630
CYREN	hsa-miR-4272	94.1462	NM_001305630
CYREN	hsa-miR-1305	93.807	NM_001305630
CYREN	hsa-miR-3065-5p	93.6401	NM_001305630
CYREN	hsa-miR-3133	93.0813	NM_001305630
CYREN	hsa-miR-449b-5p	91.5453	NM_001243755
CYREN	hsa-miR-34c-5p	91.5453	NM_001243755
CYREN	hsa-miR-7159-5p	90.7461	NM_001305630
CYREN	hsa-miR-6884-5p	89.7653	NM_001305630
CYREN	hsa-miR-485-5p	89.7653	NM_001305630
CYREN	hsa-miR-193a-3p	87.9904	NM_001305630
CYREN	hsa-miR-193b-3p	87.9904	NM_001305630
CYREN	hsa-miR-2110	86.5724	NM_001243755
CYREN	hsa-miR-1225-5p	86.0199	NM_001305630
CYREN	hsa-miR-548m	85.8192	NM_001305630
CYREN	hsa-miR-26a-1-3p	85.1846	NM_001305630
CYREN	hsa-miR-26a-2-3p	85.1846	NM_001305630
CYREN	hsa-miR-581	85.1564	NM_001243749
CYREN	hsa-miR-548c-3p	83.9872	NM_001305630
CYREN	hsa-miR-643	83.9678	NM_001305630
CYREN	hsa-miR-12123	83.0792	NM_001243755
CYREN	hsa-miR-5692a	82.7941	NM_001305630
CYREN	hsa-miR-6748-3p	82.7882	NM_001243755
CYREN	hsa-miR-31-5p	81.6669	NM_001305630

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Motifs and transcription factors (TFs) regulating CYREN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."