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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CYBRD1

Summary for CYBRD1

Gene information	Gene symbol	CYBRD1
	Ensembl ID	ENSG00000071967
	Entrez ID	79901
	Gene name	cytochrome b reductase 1
	Synonyms	CYB561A2\|DCYTB\|FLJ23462\|FRRS3
	Gene type	protein_coding
	UniProtAcc	Q53TN4

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Dataset with differentially expressed gene: CYBRD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.948498	1.31e-02
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.300381	1.91e-19
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	1.07053	0.00e+00

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Expression of CYBRD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CYBRD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CYBRD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CYBRD1	hsa-miR-3163	98.1478	NM_001256909
CYBRD1	hsa-miR-506-5p	98.0172	NM_001256909
CYBRD1	hsa-miR-548m	97.7097	NM_001256909
CYBRD1	hsa-miR-4760-5p	97.594	NM_001127383
CYBRD1	hsa-miR-6844	97.1406	NM_001127383
CYBRD1	hsa-miR-8061	97.1233	NM_001127383
CYBRD1	hsa-miR-1208	96.7692	NM_001127383
CYBRD1	hsa-miR-302e	96.2179	NM_001256909
CYBRD1	hsa-miR-3659	95.779	NM_001256909
CYBRD1	hsa-miR-4659b-3p	95.1031	NM_001127383
CYBRD1	hsa-miR-4659a-3p	95.1031	NM_001127383
CYBRD1	hsa-miR-2355-3p	94.0156	NM_001127383
CYBRD1	hsa-miR-4705	93.6878	NM_001127383
CYBRD1	hsa-miR-3685	93.6837	NM_001256909
CYBRD1	hsa-miR-188-5p	93.3804	NM_001256909
CYBRD1	hsa-miR-6866-3p	93.3434	NM_001256909
CYBRD1	hsa-miR-1279	93.0851	NM_001256909
CYBRD1	hsa-miR-8065	92.7868	NM_001256909
CYBRD1	hsa-miR-577	92.5112	NM_001127383
CYBRD1	hsa-miR-302a-3p	92.2062	NM_001256909
CYBRD1	hsa-miR-302d-3p	92.2062	NM_001256909
CYBRD1	hsa-miR-302c-3p	92.2062	NM_001256909
CYBRD1	hsa-miR-302b-3p	92.2062	NM_001256909
CYBRD1	hsa-miR-8070	92.1003	NM_001256909
CYBRD1	hsa-miR-372-3p	91.8851	NM_001256909
CYBRD1	hsa-miR-520a-3p	91.8851	NM_001256909
CYBRD1	hsa-miR-520c-3p	91.8851	NM_001256909
CYBRD1	hsa-miR-520b-3p	91.8851	NM_001256909
CYBRD1	hsa-miR-520d-3p	91.8851	NM_001256909
CYBRD1	hsa-miR-373-3p	91.8851	NM_001256909
CYBRD1	hsa-miR-520e-3p	91.8851	NM_001256909
CYBRD1	hsa-miR-944	91.2048	NM_001127383
CYBRD1	hsa-miR-556-3p	90.9635	NM_001127383
CYBRD1	hsa-miR-4645-3p	90.7361	NM_001127383
CYBRD1	hsa-miR-4686	90.4865	NM_001256909
CYBRD1	hsa-miR-610	89.9357	NM_001127383
CYBRD1	hsa-miR-3121-3p	89.8864	NM_001127383
CYBRD1	hsa-miR-335-3p	88.9714	NM_001127383
CYBRD1	hsa-miR-519d-3p	88.9413	NM_001256909
CYBRD1	hsa-miR-93-5p	88.9413	NM_001256909
CYBRD1	hsa-miR-106a-5p	88.9413	NM_001256909
CYBRD1	hsa-miR-20b-5p	88.9413	NM_001256909
CYBRD1	hsa-miR-17-5p	88.9413	NM_001256909
CYBRD1	hsa-miR-559	88.762	NM_001256909
CYBRD1	hsa-miR-526b-3p	88.5582	NM_001256909
CYBRD1	hsa-miR-20a-5p	88.3446	NM_001256909
CYBRD1	hsa-miR-106b-5p	88.3446	NM_001256909
CYBRD1	hsa-miR-12136	87.3975	NM_001256909
CYBRD1	hsa-miR-4446-3p	87.3804	NM_001127383
CYBRD1	hsa-miR-155-3p	87.1549	NM_001256909

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Motifs and transcription factors (TFs) regulating CYBRD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CYBRD1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
CYBRD1	transfac_pro__M04617	ZBTB7A (directAnnotation).
CYBRD1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CYBRD1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CYBRD1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CYBRD1	transfac_pro__M07387	ZBTB7A (directAnnotation).
CYBRD1	transfac_pro__M07436	WT1 (directAnnotation).
CYBRD1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CYBRD1	transfac_pro__M00716	ZBTB14 (directAnnotation).
CYBRD1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CYBRD1	hdpi__HIP2	UBE2K (directAnnotation).
CYBRD1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CYBRD1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CYBRD1	transfac_pro__M04893	TAF1 (directAnnotation).
CYBRD1	transfac_pro__M03876	ZBTB33 (directAnnotation).
CYBRD1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CYBRD1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CYBRD1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CYBRD1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CYBRD1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
CYBRD1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
CYBRD1	transfac_pro__M00652	NRF1 (directAnnotation).
CYBRD1	transfac_pro__M04918	EGR1 (directAnnotation).
CYBRD1	jaspar__MA0079.5	SP1 (directAnnotation).
CYBRD1	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
CYBRD1	transfac_pro__M01253	CNOT3 (directAnnotation).
CYBRD1	transfac_pro__M04817	ZBTB33 (directAnnotation).
CYBRD1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
CYBRD1	transfac_pro__M05712	ZNF134 (directAnnotation).
CYBRD1	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."