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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CYB5R4

Summary for CYB5R4

Gene information	Gene symbol	CYB5R4
	Ensembl ID	ENSG00000065615
	Entrez ID	51167
	Gene name	cytochrome b5 reductase 4
	Synonyms	b5+b5R\|dJ676J13.1\|NCB5OR
	Gene type	protein_coding
	UniProtAcc	Q7L1T6

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Dataset with differentially expressed gene: CYB5R4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.293614	2.40e-12
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.283356	6.73e-15
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.2555	7.05e-08

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Expression of CYB5R4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CYB5R4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CYB5R4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CYB5R4	hsa-miR-4719	96.7066	NM_016230
CYB5R4	hsa-miR-543	96.0574	NM_016230
CYB5R4	hsa-miR-1200	94.0076	NM_016230
CYB5R4	hsa-miR-3658	93.9503	NM_016230
CYB5R4	hsa-miR-7844-5p	93.6059	NM_016230
CYB5R4	hsa-miR-544b	92.3233	NM_016230
CYB5R4	hsa-miR-137-3p	91.5682	NM_016230
CYB5R4	hsa-miR-3143	91.3458	NM_016230
CYB5R4	hsa-miR-148a-3p	91.261	NM_016230
CYB5R4	hsa-miR-152-3p	91.261	NM_016230
CYB5R4	hsa-miR-148b-3p	91.261	NM_016230
CYB5R4	hsa-miR-3689a-5p	91.0946	NM_016230
CYB5R4	hsa-miR-3689e	91.0946	NM_016230
CYB5R4	hsa-miR-3689b-5p	91.0946	NM_016230
CYB5R4	hsa-miR-3689f	91.0946	NM_016230
CYB5R4	hsa-miR-3129-5p	90.519	NM_016230
CYB5R4	hsa-miR-199b-3p	90.519	NM_016230
CYB5R4	hsa-miR-199a-3p	90.519	NM_016230
CYB5R4	hsa-miR-744-3p	88.8586	NM_016230
CYB5R4	hsa-miR-3941	88.5205	NM_016230
CYB5R4	hsa-miR-2117	87.926	NM_016230
CYB5R4	hsa-miR-577	87.6441	NM_016230
CYB5R4	hsa-let-7c-3p	87.1389	NM_016230
CYB5R4	hsa-miR-4324	86.8572	NM_016230
CYB5R4	hsa-miR-4742-3p	86.6119	NM_016230
CYB5R4	hsa-miR-5696	86.2489	NM_016230
CYB5R4	hsa-miR-4320	85.9878	NM_016230
CYB5R4	hsa-miR-590-3p	85.7526	NM_016230
CYB5R4	hsa-miR-6809-5p	85.2095	NM_016230
CYB5R4	hsa-miR-96-3p	84.7587	NM_016230
CYB5R4	hsa-miR-8485	84.6989	NM_016230
CYB5R4	hsa-miR-378a-5p	84.6859	NM_016230
CYB5R4	hsa-miR-302c-5p	83.787	NM_016230
CYB5R4	hsa-miR-12136	82.563	NM_016230
CYB5R4	hsa-miR-4282	82.0926	NM_016230
CYB5R4	hsa-miR-520f-3p	80.9176	NM_016230
CYB5R4	hsa-miR-4659a-5p	80.3968	NM_016230

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Motifs and transcription factors (TFs) regulating CYB5R4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CYB5R4	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
CYB5R4	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
CYB5R4	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
CYB5R4	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
CYB5R4	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
CYB5R4	jaspar__MA1483.2	ELF2 (directAnnotation).
CYB5R4	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
CYB5R4	transfac_pro__M04826	EP300 (directAnnotation).
CYB5R4	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
CYB5R4	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CYB5R4	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
CYB5R4	cisbp__M08198	ELF1 (directAnnotation).
CYB5R4	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
CYB5R4	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
CYB5R4	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
CYB5R4	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
CYB5R4	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
CYB5R4	hdpi__ELF2	ELF2 (directAnnotation).
CYB5R4	metacluster_183.4	ETS1 (inferredBy_Orthology).
CYB5R4	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
CYB5R4	hdpi__FLI1	FLI1 (directAnnotation).
CYB5R4	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
CYB5R4	transfac_pro__M00492	STAT1 (directAnnotation).
CYB5R4	transfac_pro__M04748	GABPA (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."