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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CYB561

Summary for CYB561

Gene information	Gene symbol	CYB561
	Ensembl ID	ENSG00000008283
	Entrez ID	1534
	Gene name	cytochrome b561
	Synonyms	CYB561A1\|FRRS2
	Gene type	protein_coding
	UniProtAcc	P49447

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Dataset with differentially expressed gene: CYB561

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.344585	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.254238	3.42e-13
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.309194	3.27e-13
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	0.322752	3.78e-18
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.802374	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-1.66519	0.00e+00

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Expression of CYB561 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CYB561

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CYB561

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CYB561	hsa-miR-6736-3p	89.2331	NM_001017917
CYB561	hsa-miR-30d-5p	87.8249	NM_001017916
CYB561	hsa-miR-30e-5p	87.8249	NM_001017916
CYB561	hsa-miR-30a-5p	87.8249	NM_001017916
CYB561	hsa-miR-30b-5p	87.8249	NM_001017916
CYB561	hsa-miR-30c-5p	87.8249	NM_001017916
CYB561	hsa-miR-588	82.5949	NM_001017917
CYB561	hsa-miR-4701-5p	82.5949	NM_001017917
CYB561	hsa-miR-4729	80.4834	NM_001017916
CYB561	hsa-miR-182-5p	80.0492	NM_001017917

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Motifs and transcription factors (TFs) regulating CYB561

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CYB561	metacluster_130.15	ARID5B; ARID5B; BPTF (directAnnotation).
CYB561	swissregulon__hs__FUBP1	FUBP1 (directAnnotation).
CYB561	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
CYB561	transfac_pro__M06512	ZNF461 (directAnnotation).
CYB561	transfac_pro__M04844	MAX (directAnnotation).
CYB561	swissregulon__hs__FOXD3	FOXD3 (directAnnotation).
CYB561	metacluster_8.1	ZNF382 (directAnnotation).
CYB561	taipale_tf_pairs__ETV5_CEBPD_NSCGGANNTTRCGYAAN_CAP	CEBPD; ETV5 (directAnnotation).
CYB561	hdpi__RFXANK	RFXANK (directAnnotation).
CYB561	metacluster_188.3	FOXJ3; FOXJ3; FOXP1; FOXP1 (directAnnotation). FOXO1; FOXO4; FOXP1 (inferredBy_Orthology).
CYB561	metacluster_77.11	SOX12 (directAnnotation).
CYB561	transfac_public__M00278	GATA1; LDB1; LMO2; TAL1; TCF3 (inferredBy_Orthology).
CYB561	transfac_pro__M03813	POU3F3 (directAnnotation).
CYB561	hocomoco__MNX1_HUMAN.H11MO.0.D	MNX1 (directAnnotation).
CYB561	transfac_pro__M06074	ZNF732 (directAnnotation).
CYB561	transfac_pro__M02843	BBX (inferredBy_Orthology).
CYB561	jaspar__MA1933.1	SREBF2 (directAnnotation).
CYB561	transfac_pro__M06035	ZNF749 (directAnnotation).
CYB561	kznf__PRDM1_modENCODE.2_ChIP-seq	PRDM1 (directAnnotation).
CYB561	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
CYB561	metacluster_52.11	ZNF184 (directAnnotation).
CYB561	metacluster_7.13	ZFX (directAnnotation).
CYB561	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CYB561	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
CYB561	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
CYB561	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
CYB561	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
CYB561	swissregulon__hs__ELF2	ELF2 (directAnnotation).
CYB561	swissregulon__hs__ETV6	ETV6 (directAnnotation).
CYB561	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
CYB561	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
CYB561	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
CYB561	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
CYB561	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
CYB561	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."