Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE131984_Pac | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | NA | Malignant cells | -1.12071 | 3.65e-38 |
GSE169246_PacTissue | patients | Tumor tissue | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | post | Mono/Macro | 0.477873 | 4.61e-02 |
GSE169246_PacAteTissue | patients | Tumor tissue | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Immunotherapy | atezolizumab + paclitaxel | pre | Mono/Macro | 0.512859 | 2.33e-02 |
GSE207422_Tor | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | Mono/Macro | 0.547641 | 9.14e-06 |
GSE161801_PI | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Targeted therapy | carfilzomib + dexamethasone | pre | Mono/Macro | 0.816165 | 9.95e-22 |
GSE131984_JQ1 | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 | NA | Malignant cells | -0.549384 | 4.00e-13 |
GSE131984_JQ1Pac | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 + paclitaxel | NA | Malignant cells | -0.408854 | 2.70e-07 |
GSE131984_JQ1Pal | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 + palbociclib | NA | Malignant cells | -0.841524 | 1.80e-16 |
GSE175716 | PDX | Tumor tissue | Liver cancer | Advanced hepatocellular carcinoma | Targeted therapy | sorafenib | NA | Malignant cells | -2.98536 | 0.00e+00 |
Gene symbol | motif | TF_highConf |
CXCL3 | metacluster_5.1 | HIVEP1; HIVEP1; NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; NFKB2; NFKB2; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELB; RELB (directAnnotation). NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; REL; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELB; RELB; RELB (inferredBy_Orthology). |
CXCL3 | transfac_pro__M05667 | ZNF35 (directAnnotation). |
CXCL3 | homer__GGAAATTCCC_NFkB-p65-Rel | RELA (inferredBy_Orthology). |
CXCL3 | transfac_pro__M01239 | RELA (directAnnotation). |
CXCL3 | transfac_pro__M04706 | RELA (directAnnotation). |
CXCL3 | transfac_pro__M05463 | ZIM2 (directAnnotation). |
CXCL3 | transfac_pro__M06180 | ZNF445 (directAnnotation). |
CXCL3 | transfac_pro__M06798 | PRDM15 (directAnnotation). |
CXCL3 | tfdimers__MD00449 | REL; YY1 (directAnnotation). |
CXCL3 | metacluster_155.13 | ZNF135 (directAnnotation). |
CXCL3 | transfac_pro__M05935 | ZNF382 (directAnnotation). |
CXCL3 | transfac_pro__M06317 | ZNF829 (directAnnotation). |
CXCL3 | metacluster_135.11 | NR2C2 (directAnnotation). |
CXCL3 | metacluster_135.10 | MBD2; MBD2; MECP2; MECP2 (directAnnotation). |
CXCL3 | metacluster_160.20 | JUND; PRDM15 (directAnnotation). |
CXCL3 | metacluster_198.3 | ZFP64 (directAnnotation). |
CXCL3 | metacluster_141.5 | NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology). |
CXCL3 | metacluster_61.1 | DEAF1; DEAF1 (directAnnotation). |
CXCL3 | transfac_pro__M02844 | BCL6B (inferredBy_Orthology). |
CXCL3 | kznf__ZNF682_Isakova2017_SMiLE-seq | ZNF682 (directAnnotation). |
CXCL3 | taipale_tf_pairs__ETS2_RCCGGAAGTG_HT | ETS2 (directAnnotation). |
CXCL3 | taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP | ETV5; HOXA2 (directAnnotation). |
CXCL3 | taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP | ELK3; FOXO1 (directAnnotation). |
CXCL3 | taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr | ELF1; MEIS1 (directAnnotation). |
CXCL3 | taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr | ELK1; HOXA3 (directAnnotation). |
CXCL3 | metacluster_183.4 | ETS1 (inferredBy_Orthology). |
CXCL3 | taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth | ZNF385D (directAnnotation). |
CXCL3 | metacluster_81.7 | CREB1 (directAnnotation). |
CXCL3 | transfac_pro__M01298 | MECP2 (directAnnotation). |
CXCL3 | taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr | DRGX; ETV2 (directAnnotation). |
CXCL3 | hdpi__CBFB | CBFB (directAnnotation). |
CXCL3 | transfac_public__M00208 | NFKB1; RELA (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |