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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CXADR

Summary for CXADR

Gene information	Gene symbol	CXADR
	Ensembl ID	ENSG00000154639
	Entrez ID	1525
	Gene name	CXADR Ig-like cell adhesion molecule
	Synonyms	CAR
	Gene type	protein_coding
	UniProtAcc	P78310

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Dataset with differentially expressed gene: CXADR

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.332951	0.00e+00

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Expression of CXADR in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CXADR

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CXADR

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CXADR	hsa-miR-5011-5p	99.8604	NM_001338
CXADR	hsa-miR-5692c	99.5849	NM_001338
CXADR	hsa-miR-5692b	99.5849	NM_001338
CXADR	hsa-miR-340-5p	98.2628	NM_001338
CXADR	hsa-miR-5582-3p	98.0625	NM_001207065
CXADR	hsa-miR-3163	97.9749	NM_001207065
CXADR	hsa-miR-6754-3p	96.1527	NM_001207065
CXADR	hsa-miR-1252-3p	95.8835	NM_001338
CXADR	hsa-miR-513a-3p	95.0537	NM_001207065
CXADR	hsa-miR-513c-3p	95.0537	NM_001207065
CXADR	hsa-miR-374a-5p	94.8501	NM_001338
CXADR	hsa-miR-216a-3p	94.7684	NM_001207065
CXADR	hsa-miR-128-3p	94.7684	NM_001207065
CXADR	hsa-miR-122b-5p	94.7654	NM_001207065
CXADR	hsa-miR-412-3p	94.5624	NM_001207065
CXADR	hsa-miR-374b-5p	94.3951	NM_001338
CXADR	hsa-miR-548n	94.2154	NM_001338
CXADR	hsa-miR-3681-3p	94.1841	NM_001207065
CXADR	hsa-miR-4282	94.0939	NM_001338
CXADR	hsa-miR-5692a	93.7507	NM_001338
CXADR	hsa-miR-3130-3p	93.7459	NM_001338
CXADR	hsa-miR-6128	93.7108	NM_001207063
CXADR	hsa-miR-32-3p	93.6196	NM_001207065
CXADR	hsa-miR-4686	93.4819	NM_001338
CXADR	hsa-miR-10b-3p	93.4213	NM_001207066
CXADR	hsa-miR-3606-3p	93.3545	NM_001207065
CXADR	hsa-miR-506-3p	92.9743	NM_001207065
CXADR	hsa-miR-124-3p	92.9743	NM_001207065
CXADR	hsa-miR-190a-3p	92.6088	NM_001338
CXADR	hsa-miR-1297	92.273	NM_001207065
CXADR	hsa-miR-513b-5p	91.9665	NM_001207065
CXADR	hsa-miR-2115-5p	91.3483	NM_001338
CXADR	hsa-miR-493-5p	91.0783	NM_001207065
CXADR	hsa-miR-26b-5p	90.9973	NM_001207065
CXADR	hsa-miR-5584-5p	90.47	NM_001207065
CXADR	hsa-miR-5590-3p	90.4242	NM_001338
CXADR	hsa-miR-26a-5p	90.3849	NM_001207065
CXADR	hsa-miR-3942-3p	90.3228	NM_001338
CXADR	hsa-miR-4272	89.9008	NM_001207065
CXADR	hsa-miR-3529-3p	88.685	NM_001338
CXADR	hsa-miR-1277-5p	88.6376	NM_001338
CXADR	hsa-miR-142-5p	88.1041	NM_001338
CXADR	hsa-miR-3646	87.7644	NM_001338
CXADR	hsa-miR-205-3p	87.665	NM_001207065
CXADR	hsa-miR-5582-5p	87.6363	NM_001207065
CXADR	hsa-miR-548an	87.6051	NM_001207065
CXADR	hsa-miR-607	87.5727	NM_001207065
CXADR	hsa-miR-606	87.4489	NM_001207065
CXADR	hsa-miR-6074	87.1318	NM_001338
CXADR	hsa-miR-4465	86.4516	NM_001207065

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Motifs and transcription factors (TFs) regulating CXADR

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CXADR	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CXADR	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CXADR	transfac_pro__M07397	ZNF148 (directAnnotation).
CXADR	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
CXADR	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
CXADR	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
CXADR	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CXADR	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
CXADR	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
CXADR	transfac_pro__M01175	ZBTB7B (directAnnotation).
CXADR	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CXADR	tfdimers__MD00151	CHURC1 (directAnnotation).
CXADR	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CXADR	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CXADR	transfac_pro__M01303	SP1 (directAnnotation).
CXADR	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CXADR	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CXADR	transfac_pro__M02090	E2F4 (directAnnotation).
CXADR	transfac_pro__M01714	KLF15 (directAnnotation).
CXADR	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
CXADR	transfac_pro__M02089	E2F3 (directAnnotation).
CXADR	metacluster_3.14	WT1; WT1 (directAnnotation).
CXADR	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
CXADR	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
CXADR	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
CXADR	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CXADR	cisbp__M07938	E2F1 (directAnnotation).
CXADR	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
CXADR	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
CXADR	transfac_pro__M07436	WT1 (directAnnotation).
CXADR	transfac_pro__M02281	SP1 (directAnnotation).
CXADR	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
CXADR	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CXADR	transfac_pro__M02898	SMAD3 (directAnnotation).
CXADR	transfac_public__M00491	PATZ1 (directAnnotation).
CXADR	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."