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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: CX3CR1

Summary for CX3CR1

Gene informationGene symbol

CX3CR1

Ensembl ID

ENSG00000168329

Entrez ID

1524

Gene nameC-X3-C motif chemokine receptor 1
SynonymsCCRL1|CMKBRL1|CMKDR1|GPR13|V28
Gene typeprotein_coding
UniProtAcc

P49238


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Dataset with differentially expressed gene: CX3CR1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreNK cells0.4958320.00e+00

GSE169246_PacAteBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreMono/Macro-0.3307263.65e-41

GSE164237

patientsPeripheral blood mononuclear cellsMelanomaAdvanced stages of melanoma ImmunotherapypembrolizumabpreCD8+ T cells-0.536990.00e+00

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postpDCs-0.7162073.71e-05

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postNK cells-0.9009491.29e-06

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)postNK cells-0.637750.00e+00

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)preMono/Macro0.2657811.25e-26

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)preNK cells0.5072975.24e-40

GSE189460

patientsBone marrow aspirateMultiple myelomaMultiple myeloma (MM)Targeted therapybortezomib + melphalan + prednisolonepreMono/Macro0.3075964.20e-45

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostNK cells0.3755580.00e+00

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Expression of CX3CR1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to CX3CR1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.
Gene symbolMechanism

CX3CR1

Regulation by the Disease Microenvironment
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MicroRNAs (miRNA) regulating CX3CR1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
CX3CR1hsa-miR-147b-5p90.4403NM_001171174
CX3CR1hsa-miR-1227-3p90.3361NM_001171174
CX3CR1hsa-miR-426189.7138NM_001171174
CX3CR1hsa-miR-316389.3781NM_001171174
CX3CR1hsa-miR-5010-3p88.8848NM_001171174
CX3CR1hsa-miR-607787.2581NM_001171174
CX3CR1hsa-miR-6795-5p85.9084NM_001171174
CX3CR1hsa-miR-6887-5p85.9084NM_001171174
CX3CR1hsa-miR-6758-3p84.5815NM_001171174
CX3CR1hsa-miR-6516-5p82.0766NM_001171174
CX3CR1hsa-miR-644a82.0054NM_001171174
CX3CR1hsa-miR-6768-5p81.8575NM_001171174
CX3CR1hsa-miR-1227-5p81.2423NM_001171174
CX3CR1hsa-miR-550a-3-5p81.0193NM_001171174
CX3CR1hsa-miR-550a-5p81.0193NM_001171174
CX3CR1hsa-miR-1271-3p81.0193NM_001171174
CX3CR1hsa-miR-550b-2-5p80.4447NM_001171174
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Motifs and transcription factors (TFs) regulating CX3CR1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
CX3CR1transfac_pro__M00655ETV4 (directAnnotation).
CX3CR1tfdimers__MD00138IRF1; IRF2; IRF3; IRF4; IRF5; IRF7; IRF8; IRF9; MYB (directAnnotation).
CX3CR1transfac_pro__M05560AEBP2 (directAnnotation).
CX3CR1swissregulon__hs__SPI1SPI1 (directAnnotation).
CX3CR1homer__ACAGGATGTGGT_ETS_RUNXRUNX1 (directAnnotation).
CX3CR1taipale_tf_pairs__ELK1_EVX1_RSCGGWANNNNYMATTA_CAP_reprELK1; EVX1 (directAnnotation).
CX3CR1transfac_pro__M05836ZNF572 (directAnnotation).
CX3CR1transfac_pro__M05698ZNF141 (directAnnotation).
CX3CR1metacluster_174.4PBX1; PBX1; PBX1; PBX1 (directAnnotation).
CX3CR1metacluster_20.5DLX1; DLX4; DLX4 (directAnnotation).
CX3CR1cisbp__M00282PHOX2B (directAnnotation).
CX3CR1jaspar__MA1509.1IRF6 (directAnnotation).
CX3CR1metacluster_9.47PAX7 (inferredBy_Orthology).
CX3CR1taipale_tf_pairs__ELK1_SPDEF_NSMGGACGGAYNTCCKSN_CAPELK1; SPDEF (directAnnotation).
CX3CR1metacluster_2.8IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
CX3CR1metacluster_22.33MAFK (inferredBy_Orthology).
CX3CR1taipale_cyt_meth__IRF6_ACCGAWACY_FL_methIRF6 (directAnnotation).
CX3CR1metacluster_22.32NFE2L2 (directAnnotation).
CX3CR1metacluster_22.37BACH1 (directAnnotation).
CX3CR1metacluster_22.1MAFF (inferredBy_Orthology).
CX3CR1taipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAPETV2; SPDEF (directAnnotation).
CX3CR1transfac_pro__M12556ETV4 (directAnnotation).
CX3CR1taipale_tf_pairs__FLI1_MAX_RSCGGAANCACGTGN_CAPFLI1; MAX (directAnnotation).
CX3CR1metacluster_22.19NFE2 (directAnnotation).
CX3CR1metacluster_22.36BACH2 (directAnnotation).
CX3CR1metacluster_22.20MAFG (directAnnotation).
CX3CR1transfac_pro__M05927ZNF408 (directAnnotation).
CX3CR1tfdimers__MD00147ELF5; TFAP2C (directAnnotation).
CX3CR1transfac_pro__M05756ZNF470 (directAnnotation).
CX3CR1metacluster_74.23HNF1B (inferredBy_Orthology).
CX3CR1tfdimers__MD00415PDX1; POU3F2 (directAnnotation).
CX3CR1taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAPELK1; FOXO1 (directAnnotation).
CX3CR1taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_reprERF; FOXI1 (directAnnotation).
CX3CR1taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAPETV2; FOXI1 (directAnnotation).
CX3CR1taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAPETV4; FOXO1 (directAnnotation).
CX3CR1taipale_tf_pairs__ETS2_RCCGGAAGTG_HTETS2 (directAnnotation).
CX3CR1taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAPETV5; FOXI1 (directAnnotation).
CX3CR1hdpi__FLI1FLI1 (directAnnotation).
CX3CR1transfac_pro__M06881ZNF549 (directAnnotation).
CX3CR1taipale_tf_pairs__CUX1_NHLH1_NNCAGCTGNNNNNNNNNATYGATN_CAP_reprCUX1; NHLH1 (directAnnotation).
CX3CR1metacluster_77.21SOX14 (directAnnotation).
CX3CR1cisbp__M02385MYRF (directAnnotation).
CX3CR1taipale_tf_pairs__GCM1_HOXA13_RKRNGGGNNATAAA_CAPGCM1; HOXA13 (directAnnotation).
CX3CR1transfac_pro__M06678ZNF287 (inferredBy_Orthology).
CX3CR1tfdimers__MD00114FOXG1; FOXO1; NR5A1 (directAnnotation).
CX3CR1kznf__ZFP90_Imbeault2017_RP_RCADEZFP90 (directAnnotation).
CX3CR1transfac_pro__M01660GABPA (directAnnotation).
CX3CR1metacluster_22.28BACH1 (directAnnotation).
CX3CR1transfac_pro__M06553ZNF420 (directAnnotation).
CX3CR1transfac_pro__M05762ZNF774 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."