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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CWC27

Summary for CWC27

Gene information	Gene symbol	CWC27
	Ensembl ID	ENSG00000153015
	Entrez ID	10283
	Gene name	CWC27 spliceosome associated cyclophilin
	Synonyms	NY-CO-10\|SDCCAG-10\|SDCCAG10
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CWC27

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.437659	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.258315	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.282781	2.61e-13
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.288257	3.39e-07
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.474356	1.08e-29

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Expression of CWC27 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CWC27

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CWC27

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CWC27	hsa-miR-4694-3p	97.4529	NM_001297645
CWC27	hsa-miR-190a-5p	96.5343	NM_001297645
CWC27	hsa-miR-190b-5p	96.5343	NM_001297645
CWC27	hsa-miR-4482-3p	95.6689	NM_001318000
CWC27	hsa-miR-4766-3p	94.9721	NM_005869
CWC27	hsa-miR-205-3p	93.6307	NM_005869
CWC27	hsa-miR-144-3p	91.8831	NM_001297645
CWC27	hsa-miR-526b-5p	91.1087	NM_001297645
CWC27	hsa-miR-153-5p	91.0848	NM_001318000
CWC27	hsa-miR-4267	89.7538	NM_001318000
CWC27	hsa-miR-6885-3p	89.6447	NM_001318000
CWC27	hsa-miR-5689	89.2528	NM_001318000
CWC27	hsa-miR-3942-3p	89.2244	NM_005869
CWC27	hsa-miR-3160-5p	89.0761	NM_001318000
CWC27	hsa-miR-6780a-3p	87.8581	NM_001318000
CWC27	hsa-miR-374a-5p	87.5967	NM_005869
CWC27	hsa-miR-4476	85.9067	NM_001297645
CWC27	hsa-miR-664a-3p	85.7342	NM_001297645
CWC27	hsa-miR-4474-5p	85.3422	NM_001297645
CWC27	hsa-miR-12123	85.2539	NM_001297645
CWC27	hsa-miR-4738-3p	85.2413	NM_001318000
CWC27	hsa-miR-4749-5p	85.0745	NM_001297645
CWC27	hsa-miR-4706	85.0745	NM_001297645
CWC27	hsa-miR-374b-5p	84.915	NM_005869
CWC27	hsa-miR-3622b-5p	84.6155	NM_001318000
CWC27	hsa-miR-3529-3p	84.3989	NM_001318000
CWC27	hsa-miR-4533	84.1461	NM_005869
CWC27	hsa-miR-5692b	84.0622	NM_005869
CWC27	hsa-miR-5692c	84.0622	NM_005869
CWC27	hsa-miR-502-3p	83.8734	NM_001318000
CWC27	hsa-miR-501-3p	83.8734	NM_001318000
CWC27	hsa-miR-4999-3p	82.4781	NM_001297645
CWC27	hsa-miR-6071	82.4113	NM_001318000
CWC27	hsa-miR-3190-3p	81.8834	NM_005869
CWC27	hsa-miR-5589-5p	81.8517	NM_001318000
CWC27	hsa-miR-6764-5p	81.1169	NM_001318000
CWC27	hsa-miR-6133	80.8596	NM_001318000
CWC27	hsa-miR-6130	80.8596	NM_001318000
CWC27	hsa-miR-4510	80.8596	NM_001318000
CWC27	hsa-miR-6129	80.8596	NM_001318000
CWC27	hsa-miR-6127	80.8596	NM_001318000

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Motifs and transcription factors (TFs) regulating CWC27

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CWC27	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
CWC27	hdpi__FLI1	FLI1 (directAnnotation).
CWC27	transfac_pro__M04826	EP300 (directAnnotation).
CWC27	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
CWC27	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
CWC27	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
CWC27	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
CWC27	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
CWC27	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
CWC27	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
CWC27	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
CWC27	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).
CWC27	cisbp__M02645	ETS1 (directAnnotation).
CWC27	jaspar__MA1708.1	ETV7 (directAnnotation).
CWC27	metacluster_183.4	ETS1 (inferredBy_Orthology).
CWC27	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
CWC27	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CWC27	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."