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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CWC25

Summary for CWC25

Gene information	Gene symbol	CWC25
	Ensembl ID	ENSG00000276761
	Entrez ID	54883
	Gene name	CWC25 spliceosome associated protein homolog
	Synonyms	CCDC49\|FLJ20291
	Gene type	protein_coding
	UniProtAcc	Q9NXE8

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Dataset with differentially expressed gene: CWC25

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.333626	3.28e-27
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.265457	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.43714	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.269422	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.579036	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.301298	4.69e-36
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.275629	1.76e-15

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Expression of CWC25 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CWC25

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CWC25

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CWC25	hsa-miR-4311	97.4891	NM_017748
CWC25	hsa-miR-340-5p	96.4594	NM_017748
CWC25	hsa-miR-1276	95.0738	NM_017748
CWC25	hsa-miR-4299	95.0028	NM_017748
CWC25	hsa-miR-3123	94.8793	NM_017748
CWC25	hsa-miR-556-3p	94.7539	NM_017748
CWC25	hsa-miR-4308	93.8314	NM_017748
CWC25	hsa-miR-935	93.3667	NM_017748
CWC25	hsa-miR-493-5p	93.1688	NM_017748
CWC25	hsa-miR-583	92.9986	NM_017748
CWC25	hsa-miR-3158-3p	91.8443	NM_017748
CWC25	hsa-miR-4680-5p	91.4407	NM_017748
CWC25	hsa-miR-3646	90.0212	NM_017748
CWC25	hsa-miR-6124	89.3424	NM_017748
CWC25	hsa-miR-524-5p	88.2592	NM_017748
CWC25	hsa-miR-520d-5p	88.2592	NM_017748
CWC25	hsa-miR-6773-3p	87.6121	NM_017748
CWC25	hsa-miR-3130-5p	87.5647	NM_017748
CWC25	hsa-miR-2909	87.2966	NM_017748
CWC25	hsa-miR-4707-5p	85.3238	NM_017748
CWC25	hsa-miR-4482-5p	84.9447	NM_017748
CWC25	hsa-miR-6791-5p	84.169	NM_017748
CWC25	hsa-miR-6778-3p	82.5712	NM_017748
CWC25	hsa-miR-6792-5p	82.0349	NM_017748
CWC25	hsa-miR-7515	80.6519	NM_017748

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Motifs and transcription factors (TFs) regulating CWC25

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CWC25	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
CWC25	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
CWC25	jaspar__MA1483.2	ELF2 (directAnnotation).
CWC25	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
CWC25	cisbp__M08198	ELF1 (directAnnotation).
CWC25	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CWC25	transfac_pro__M02913	SP140 (inferredBy_Orthology).
CWC25	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
CWC25	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
CWC25	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
CWC25	hdpi__TIMELESS	TIMELESS (directAnnotation).
CWC25	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
CWC25	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
CWC25	transfac_pro__M01861	ATF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."