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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CUL5

Summary for CUL5

Gene information	Gene symbol	CUL5
	Ensembl ID	ENSG00000166266
	Entrez ID	8065
	Gene name	cullin 5
	Synonyms	VACM-1
	Gene type	protein_coding
	UniProtAcc	Q93034

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Dataset with differentially expressed gene: CUL5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.50725	1.29e-32
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.294772	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.403568	3.85e-41

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Expression of CUL5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CUL5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
CUL5	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating CUL5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CUL5	hsa-miR-4668-3p	99.3698	NM_003478
CUL5	hsa-miR-153-5p	99.0145	NM_003478
CUL5	hsa-miR-182-5p	97.4656	NM_003478
CUL5	hsa-miR-4282	96.0642	NM_003478
CUL5	hsa-miR-1468-3p	95.5531	NM_003478
CUL5	hsa-miR-4310	95.3834	NM_003478
CUL5	hsa-miR-3163	94.6484	NM_003478
CUL5	hsa-miR-4799-5p	93.927	NM_003478
CUL5	hsa-miR-3714	93.5735	NM_003478
CUL5	hsa-miR-4470	92.9425	NM_003478
CUL5	hsa-miR-595	92.3628	NM_003478
CUL5	hsa-miR-33a-3p	92.2399	NM_003478
CUL5	hsa-miR-380-3p	92.0512	NM_003478
CUL5	hsa-miR-6502-3p	91.9724	NM_003478
CUL5	hsa-miR-6512-3p	91.4859	NM_003478
CUL5	hsa-miR-6720-5p	91.4859	NM_003478
CUL5	hsa-miR-12136	91.272	NM_003478
CUL5	hsa-miR-335-3p	90.7459	NM_003478
CUL5	hsa-miR-7157-5p	90.683	NM_003478
CUL5	hsa-miR-10400-3p	90.6158	NM_003478
CUL5	hsa-miR-4674	90.6158	NM_003478
CUL5	hsa-miR-216b-3p	89.8314	NM_003478
CUL5	hsa-miR-6072	88.6024	NM_003478
CUL5	hsa-miR-6891-3p	88.3241	NM_003478
CUL5	hsa-miR-4482-3p	88.0566	NM_003478
CUL5	hsa-miR-302c-5p	87.9304	NM_003478
CUL5	hsa-miR-152-3p	87.2659	NM_003478
CUL5	hsa-miR-148a-3p	87.2659	NM_003478
CUL5	hsa-miR-148b-3p	87.2659	NM_003478
CUL5	hsa-miR-1910-3p	86.5979	NM_003478
CUL5	hsa-miR-6511a-5p	86.5979	NM_003478
CUL5	hsa-miR-196a-3p	86.4551	NM_003478
CUL5	hsa-miR-493-5p	86.4276	NM_003478
CUL5	hsa-miR-217-5p	86.2875	NM_003478
CUL5	hsa-miR-6515-3p	85.5157	NM_003478
CUL5	hsa-miR-1255b-2-3p	85.086	NM_003478
CUL5	hsa-miR-548n	83.9346	NM_003478
CUL5	hsa-miR-5089-3p	83.5428	NM_003478
CUL5	hsa-miR-769-5p	83.2312	NM_003478
CUL5	hsa-miR-891a-3p	82.9756	NM_003478
CUL5	hsa-miR-133a-5p	82.7858	NM_003478
CUL5	hsa-miR-5696	82.6256	NM_003478
CUL5	hsa-miR-548v	82.5498	NM_003478
CUL5	hsa-miR-124-3p	82.4811	NM_003478
CUL5	hsa-miR-506-3p	82.4811	NM_003478
CUL5	hsa-miR-1976	82.067	NM_003478
CUL5	hsa-miR-548g-3p	81.8937	NM_003478
CUL5	hsa-miR-603	81.8853	NM_003478
CUL5	hsa-miR-3910	81.5433	NM_003478
CUL5	hsa-miR-889-3p	81.387	NM_003478

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Motifs and transcription factors (TFs) regulating CUL5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CUL5	metacluster_135.11	NR2C2 (directAnnotation).
CUL5	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CUL5	metacluster_7.13	ZFX (directAnnotation).
CUL5	cisbp__M00968	MTF2 (directAnnotation).
CUL5	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CUL5	metacluster_160.20	JUND; PRDM15 (directAnnotation).
CUL5	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CUL5	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
CUL5	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CUL5	cisbp__M00788	ZFY (inferredBy_Orthology).
CUL5	metacluster_175.1	ZNF283 (directAnnotation).
CUL5	hdpi__ZNF304	ZNF304 (directAnnotation).
CUL5	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CUL5	transfac_pro__M01199	TRIM28 (directAnnotation).
CUL5	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CUL5	transfac_pro__M03806	ZBTB7C (directAnnotation).
CUL5	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CUL5	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
CUL5	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
CUL5	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CUL5	jaspar__MA0748.2	YY2 (directAnnotation).
CUL5	metacluster_182.10	ZFX (directAnnotation).
CUL5	cisbp__M01863	ZNF711 (inferredBy_Orthology).
CUL5	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
CUL5	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
CUL5	hdpi__TIMELESS	TIMELESS (directAnnotation).
CUL5	metacluster_191.5	SPDEF (inferredBy_Orthology).
CUL5	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
CUL5	hdpi__ELF2	ELF2 (directAnnotation).
CUL5	transfac_pro__M01861	ATF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."