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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CUL4B

Summary for CUL4B

Gene information	Gene symbol	CUL4B
	Ensembl ID	ENSG00000158290
	Entrez ID	8450
	Gene name	cullin 4B
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q13620

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Dataset with differentially expressed gene: CUL4B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.03357	1.34e-06

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Expression of CUL4B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CUL4B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
CUL4B	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating CUL4B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CUL4B	hsa-miR-4531	95.2376	NM_001079872
CUL4B	hsa-miR-4251	95.0072	NM_001079872
CUL4B	hsa-miR-6885-3p	94.9408	NM_001079872
CUL4B	hsa-miR-579-3p	94.8235	NM_001079872
CUL4B	hsa-miR-130a-5p	94.2244	NM_001079872
CUL4B	hsa-miR-6830-5p	94.2129	NM_001079872
CUL4B	hsa-miR-3646	93.875	NM_001079872
CUL4B	hsa-miR-664b-3p	93.5463	NM_001079872
CUL4B	hsa-miR-148b-5p	92.7419	NM_001079872
CUL4B	hsa-miR-6874-3p	92.7419	NM_001079872
CUL4B	hsa-miR-300	92.6517	NM_001079872
CUL4B	hsa-miR-381-3p	92.6517	NM_001079872
CUL4B	hsa-miR-498-5p	90.6994	NM_001079872
CUL4B	hsa-miR-133b	90.5584	NM_001079872
CUL4B	hsa-miR-133a-3p	90.5584	NM_001079872
CUL4B	hsa-miR-3977	90.491	NM_001079872
CUL4B	hsa-miR-4503	90.3774	NM_001079872
CUL4B	hsa-miR-6862-5p	90.3774	NM_001079872
CUL4B	hsa-miR-4253	90.3774	NM_001079872
CUL4B	hsa-miR-194-5p	89.6232	NM_001079872
CUL4B	hsa-miR-5692a	88.6589	NM_001079872
CUL4B	hsa-miR-5688	88.1855	NM_001079872
CUL4B	hsa-miR-561-5p	87.7572	NM_001079872
CUL4B	hsa-miR-1252-3p	87.7555	NM_001079872
CUL4B	hsa-miR-495-3p	87.7393	NM_001079872
CUL4B	hsa-miR-7159-5p	86.9346	NM_001079872
CUL4B	hsa-miR-6826-5p	86.7884	NM_001079872
CUL4B	hsa-miR-5003-3p	86.5914	NM_001079872
CUL4B	hsa-miR-561-3p	86.3564	NM_001079872
CUL4B	hsa-miR-1265	86.1327	NM_001079872
CUL4B	hsa-miR-4482-3p	85.9261	NM_001079872
CUL4B	hsa-miR-3671	85.5003	NM_001079872
CUL4B	hsa-miR-942-5p	85.2936	NM_001079872
CUL4B	hsa-miR-6809-3p	85.0719	NM_001079872
CUL4B	hsa-miR-12131	84.1891	NM_001079872
CUL4B	hsa-miR-4451	83.5956	NM_001079872
CUL4B	hsa-miR-570-3p	83.3696	NM_001079872
CUL4B	hsa-miR-12124	83.257	NM_001079872
CUL4B	hsa-miR-6776-3p	83.2297	NM_001079872
CUL4B	hsa-miR-5696	82.951	NM_001079872
CUL4B	hsa-miR-4764-5p	82.5625	NM_001079872
CUL4B	hsa-miR-6848-3p	82.5498	NM_001079872
CUL4B	hsa-miR-6843-3p	82.5498	NM_001079872
CUL4B	hsa-miR-4659a-3p	82.5097	NM_001079872
CUL4B	hsa-miR-4659b-3p	82.5097	NM_001079872
CUL4B	hsa-miR-4645-3p	81.8744	NM_001079872
CUL4B	hsa-miR-545-5p	81.2415	NM_001079872
CUL4B	hsa-miR-10395-3p	81.115	NM_001079872
CUL4B	hsa-miR-181a-2-3p	80.9924	NM_001079872
CUL4B	hsa-miR-5584-5p	80.608	NM_001079872

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Motifs and transcription factors (TFs) regulating CUL4B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CUL4B	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
CUL4B	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
CUL4B	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CUL4B	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CUL4B	transfac_pro__M07436	WT1 (directAnnotation).
CUL4B	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CUL4B	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CUL4B	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CUL4B	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CUL4B	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CUL4B	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CUL4B	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."