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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CUL1

Summary for CUL1

Gene information	Gene symbol	CUL1
	Ensembl ID	ENSG00000055130
	Entrez ID	8454
	Gene name	cullin 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q13616

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Dataset with differentially expressed gene: CUL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.3832	0.00e+00

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Expression of CUL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CUL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CUL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CUL1	hsa-miR-377-3p	97.0324	NM_003592
CUL1	hsa-miR-1284	96.9487	NM_003592
CUL1	hsa-miR-4699-3p	93.4929	NM_003592
CUL1	hsa-miR-603	92.6767	NM_003592
CUL1	hsa-miR-522-3p	92.3304	NM_003592
CUL1	hsa-miR-224-3p	92.3304	NM_003592
CUL1	hsa-miR-6762-3p	91.7711	NM_003592
CUL1	hsa-let-7a-2-3p	90.3841	NM_003592
CUL1	hsa-let-7g-3p	90.3841	NM_003592
CUL1	hsa-miR-6848-3p	90.3111	NM_003592
CUL1	hsa-miR-6843-3p	90.3111	NM_003592
CUL1	hsa-miR-507	89.8999	NM_003592
CUL1	hsa-miR-557	89.8999	NM_003592
CUL1	hsa-miR-6882-3p	89.0476	NM_003592
CUL1	hsa-let-7b-3p	87.464	NM_003592
CUL1	hsa-let-7f-1-3p	87.464	NM_003592
CUL1	hsa-let-7a-3p	87.464	NM_003592
CUL1	hsa-miR-98-3p	87.464	NM_003592
CUL1	hsa-miR-4775	87.0826	NM_003592
CUL1	hsa-miR-2116-5p	86.96	NM_003592
CUL1	hsa-miR-4324	86.8101	NM_003592
CUL1	hsa-miR-544b	86.8101	NM_003592
CUL1	hsa-miR-1200	86.1463	NM_003592
CUL1	hsa-miR-657	83.5627	NM_003592

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Motifs and transcription factors (TFs) regulating CUL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CUL1	metacluster_7.13	ZFX (directAnnotation).
CUL1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
CUL1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
CUL1	metacluster_151.2	ZNF23 (directAnnotation).
CUL1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CUL1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CUL1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
CUL1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CUL1	metacluster_182.10	ZFX (directAnnotation).
CUL1	hdpi__ETV4	ETV4 (directAnnotation).
CUL1	jaspar__MA0748.2	YY2 (directAnnotation).
CUL1	transfac_pro__M05628	ZNF735 (directAnnotation).
CUL1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
CUL1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CUL1	jaspar__MA0079.5	SP1 (directAnnotation).
CUL1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
CUL1	transfac_pro__M04826	EP300 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."