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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CTTN

Summary for CTTN

Gene information	Gene symbol	CTTN
	Ensembl ID	ENSG00000288401
	Entrez ID	2017
	Gene name	cortactin
	Synonyms	EMS1
	Gene type	protein_coding
	UniProtAcc	Q14247

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Dataset with differentially expressed gene: CTTN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.434071	1.40e-39
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.313618	8.47e-03
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.281887	9.57e-14
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.842234	0.00e+00
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.301158	1.13e-14

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Expression of CTTN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CTTN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CTTN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CTTN	hsa-miR-182-5p	99.4819	NM_005231
CTTN	hsa-miR-96-5p	98.4048	NM_005231
CTTN	hsa-miR-12133	98.3559	NM_005231
CTTN	hsa-miR-548e-5p	98.2564	NM_005231
CTTN	hsa-miR-1271-5p	98.0978	NM_005231
CTTN	hsa-miR-3613-3p	97.9971	NM_005231
CTTN	hsa-miR-495-5p	97.6175	NM_001184740
CTTN	hsa-miR-4470	97.538	NM_005231
CTTN	hsa-miR-4711-5p	94.947	NM_005231
CTTN	hsa-miR-338-5p	94.2751	NM_005231
CTTN	hsa-miR-548ap-3p	92.8521	NM_005231
CTTN	hsa-miR-548t-3p	92.8521	NM_005231
CTTN	hsa-miR-548aa	92.8521	NM_005231
CTTN	hsa-miR-548as-3p	90.4858	NM_005231
CTTN	hsa-miR-3685	88.4557	NM_005231
CTTN	hsa-miR-545-3p	87.6443	NM_005231
CTTN	hsa-miR-10393-5p	86.5577	NM_001184740
CTTN	hsa-miR-7114-5p	85.7547	NM_005231
CTTN	hsa-miR-4680-3p	85.3208	NM_001184740
CTTN	hsa-miR-134-3p	85.208	NM_005231
CTTN	hsa-miR-33a-3p	83.5797	NM_005231
CTTN	hsa-miR-142-3p	82.8231	NM_005231
CTTN	hsa-miR-548v	82.3375	NM_001184740
CTTN	hsa-miR-4775	80.8311	NM_005231

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Motifs and transcription factors (TFs) regulating CTTN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CTTN	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
CTTN	transfac_pro__M05547	PLAGL1 (inferredBy_Orthology).
CTTN	tfdimers__MD00369	ZNF384 (directAnnotation).
CTTN	transfac_pro__M01861	ATF1 (directAnnotation).
CTTN	metacluster_98.1	ZNF524 (directAnnotation).
CTTN	transfac_pro__M04826	EP300 (directAnnotation).
CTTN	swissregulon__hs__ETV6	ETV6 (directAnnotation).
CTTN	jaspar__MA1933.1	SREBF2 (directAnnotation).
CTTN	cisbp__M08198	ELF1 (directAnnotation).
CTTN	taipale_tf_pairs__ETV2_DLX3_RSCGGAANNNNNNNTAATKR_CAP_repr	DLX3; ETV2 (directAnnotation).
CTTN	hdpi__TP73	TP73 (directAnnotation).
CTTN	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
CTTN	transfac_pro__M00492	STAT1 (directAnnotation).
CTTN	cisbp__M00341	PAX6 (directAnnotation).
CTTN	tfdimers__MD00483	ZBTB14 (directAnnotation).
CTTN	tfdimers__MD00364	WT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."