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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CTSV

Summary for CTSV

Gene information	Gene symbol	CTSV
	Ensembl ID	ENSG00000136943
	Entrez ID	1515
	Gene name	cathepsin V
	Synonyms	CTSL2\|CTSU
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CTSV

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.389826	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.31144	0.00e+00

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Expression of CTSV in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CTSV

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CTSV

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CTSV	hsa-miR-4282	96.1901	NM_001201575
CTSV	hsa-miR-4503	93.1569	NM_001201575
CTSV	hsa-miR-8068	92.3423	NM_001201575
CTSV	hsa-miR-935	91.5232	NM_001201575
CTSV	hsa-miR-1297	89.768	NM_001201575
CTSV	hsa-miR-26b-5p	88.6301	NM_001201575
CTSV	hsa-miR-26a-5p	88.6301	NM_001201575
CTSV	hsa-miR-4328	87.156	NM_001201575
CTSV	hsa-miR-4465	87.0338	NM_001201575
CTSV	hsa-miR-12122	86.6117	NM_001201575
CTSV	hsa-miR-6827-3p	86.601	NM_001201575
CTSV	hsa-miR-12124	86.0183	NM_001201575
CTSV	hsa-miR-12114	85.4654	NM_001201575
CTSV	hsa-miR-3662	83.8353	NM_001201575
CTSV	hsa-miR-125b-2-3p	83.3282	NM_001201575
CTSV	hsa-miR-340-3p	83.2364	NM_001201575
CTSV	hsa-miR-586	83.0281	NM_001201575
CTSV	hsa-miR-8485	82.6806	NM_001201575
CTSV	hsa-miR-4670-3p	82.6164	NM_001201575
CTSV	hsa-miR-4463	82.2898	NM_001201575

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Motifs and transcription factors (TFs) regulating CTSV

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CTSV	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
CTSV	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
CTSV	dbtfbs__ZNF121_HEK293_ENCSR224QDY_merged_N3	ZNF121 (directAnnotation).
CTSV	transfac_pro__M06331	ZNF343 (directAnnotation).
CTSV	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
CTSV	transfac_pro__M02089	E2F3 (directAnnotation).
CTSV	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CTSV	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
CTSV	transfac_pro__M04817	ZBTB33 (directAnnotation).
CTSV	tfdimers__MD00483	ZBTB14 (directAnnotation).
CTSV	cisbp__M07938	E2F1 (directAnnotation).
CTSV	cisbp__M00968	MTF2 (directAnnotation).
CTSV	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CTSV	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CTSV	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
CTSV	jaspar__MA1122.1	TFDP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CTSV	"3-amino-5-phenylpentane"	DB02869	small molecule
CTSV	"4-Methylpiperazin-1-Yl Carbonyl Group"	DB04451	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."