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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: CTDSPL2

Summary for CTDSPL2

Gene informationGene symbol

CTDSPL2

Ensembl ID

ENSG00000137770

Entrez ID

51496

Gene nameCTD small phosphatase like 2
SynonymsFLJ10523|HSPC129
Gene typeprotein_coding
UniProtAcc

Q05D32


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Dataset with differentially expressed gene: CTDSPL2

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE138267

CDXTumor tissueLung cancerSmall cell lung cancer (SCLC)ChemotherapyNANAMalignant cells0.2623660.00e+00

GSE168668

LNCaP cell lineCell lineProstate cancerProstate cancerTargeted therapyenzalutamideNAMalignant cells-0.2507030.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostCD4+ T cells-0.2853660.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostCD8+ T cells-0.3237420.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostNK cells-0.3896070.00e+00

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Expression of CTDSPL2 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to CTDSPL2

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CTDSPL2

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
CTDSPL2hsa-miR-7-1-3p99.7522NM_016396
CTDSPL2hsa-miR-7-2-3p99.7522NM_016396
CTDSPL2hsa-miR-570098.6789NM_016396
CTDSPL2hsa-miR-366298.1498NM_016396
CTDSPL2hsa-miR-4753-3p97.2289NM_016396
CTDSPL2hsa-miR-364696.409NM_016396
CTDSPL2hsa-miR-427696.2632NM_016396
CTDSPL2hsa-miR-316396.2275NM_016396
CTDSPL2hsa-miR-18b-3p95.9523NM_016396
CTDSPL2hsa-miR-4802-3p95.8178NM_016396
CTDSPL2hsa-miR-1468-3p95.3997NM_016396
CTDSPL2hsa-miR-312395.2847NM_016396
CTDSPL2hsa-miR-7152-5p94.2019NM_016396
CTDSPL2hsa-miR-486-5p93.8654NM_016396
CTDSPL2hsa-miR-20a-3p93.7176NM_016396
CTDSPL2hsa-miR-1277-5p93.5154NM_016396
CTDSPL2hsa-miR-427993.2445NM_016396
CTDSPL2hsa-miR-4485-3p93.2117NM_016396
CTDSPL2hsa-miR-548av-3p93.1493NM_016396
CTDSPL2hsa-miR-548aj-3p92.6569NM_016396
CTDSPL2hsa-miR-548j-3p92.6569NM_016396
CTDSPL2hsa-miR-548aq-3p92.6569NM_016396
CTDSPL2hsa-miR-548x-3p92.6569NM_016396
CTDSPL2hsa-miR-548ae-3p92.6569NM_016396
CTDSPL2hsa-miR-548ah-3p92.6569NM_016396
CTDSPL2hsa-miR-548am-3p92.6569NM_016396
CTDSPL2hsa-miR-3663-3p92.6416NM_016396
CTDSPL2hsa-miR-3184-3p92.0363NM_016396
CTDSPL2hsa-miR-579-3p91.9515NM_016396
CTDSPL2hsa-miR-664b-3p91.9515NM_016396
CTDSPL2hsa-miR-42191.873NM_016396
CTDSPL2hsa-miR-6504-3p91.6808NM_016396
CTDSPL2hsa-miR-10399-5p91.6808NM_016396
CTDSPL2hsa-miR-541-5p91.4674NM_016396
CTDSPL2hsa-miR-450a-1-3p90.8815NM_016396
CTDSPL2hsa-miR-63090.8413NM_016396
CTDSPL2hsa-miR-493-5p90.7966NM_016396
CTDSPL2hsa-miR-130590.7352NM_016396
CTDSPL2hsa-miR-7856-5p90.7271NM_016396
CTDSPL2hsa-miR-519090.5479NM_016396
CTDSPL2hsa-miR-3606-3p90.0672NM_016396
CTDSPL2hsa-miR-4709-5p89.914NM_016396
CTDSPL2hsa-miR-5197-5p89.9076NM_016396
CTDSPL2hsa-miR-3925-5p89.8981NM_016396
CTDSPL2hsa-miR-513a-3p89.6801NM_016396
CTDSPL2hsa-miR-513c-3p89.6801NM_016396
CTDSPL2hsa-miR-552-3p89.6476NM_016396
CTDSPL2hsa-miR-990289.5734NM_016396
CTDSPL2hsa-miR-432889.3675NM_016396
CTDSPL2hsa-miR-548aa89.1098NM_016396
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Motifs and transcription factors (TFs) regulating CTDSPL2

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
CTDSPL2taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_reprGCM1; SPDEF (directAnnotation).
CTDSPL2transfac_pro__M01219SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CTDSPL2transfac_pro__M07397ZNF148 (directAnnotation).
CTDSPL2metacluster_131.7EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
CTDSPL2metacluster_131.4EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
CTDSPL2dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1GMEB1 (directAnnotation).
CTDSPL2metacluster_15.2E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CTDSPL2metacluster_3.11SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
CTDSPL2transfac_pro__M01175ZBTB7B (directAnnotation).
CTDSPL2taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_methZNF460 (directAnnotation).
CTDSPL2tfdimers__MD00151CHURC1 (directAnnotation).
CTDSPL2metacluster_3.7SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CTDSPL2metacluster_15.1E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CTDSPL2transfac_pro__M01303SP1 (directAnnotation).
CTDSPL2swissregulon__hs__CHD1CHD1 (directAnnotation).
CTDSPL2transfac_pro__M02090E2F4 (directAnnotation).
CTDSPL2transfac_pro__M01714KLF15 (directAnnotation).
CTDSPL2metacluster_15.3E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CTDSPL2jaspar__MA1122.1TFDP1 (directAnnotation).
CTDSPL2hocomoco__PROX1_HUMAN.H11MO.0.DPROX1 (directAnnotation).
CTDSPL2transfac_pro__M02089E2F3 (directAnnotation).
CTDSPL2metacluster_3.14WT1; WT1 (directAnnotation).
CTDSPL2metacluster_3.4SP1; SP2; SP2; SP3 (directAnnotation).
CTDSPL2metacluster_126.3LIN28B; LIN28B (directAnnotation).
CTDSPL2hocomoco__EGR4_HUMAN.H11MO.0.DEGR4 (directAnnotation).
CTDSPL2metacluster_3.5KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CTDSPL2cisbp__M07938E2F1 (directAnnotation).
CTDSPL2kznf__ZNF202_Imbeault2017_OM_MEMEZNF202 (directAnnotation).
CTDSPL2homer__GGCGGGAARN_E2F6E2F6 (directAnnotation).
CTDSPL2transfac_pro__M07436WT1 (directAnnotation).
CTDSPL2transfac_pro__M02281SP1 (directAnnotation).
CTDSPL2taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_reprELF1; GCM1 (directAnnotation).
CTDSPL2kznf__ZNF730_Imbeault2017_RP_RCADEZNF730 (directAnnotation).
CTDSPL2transfac_pro__M02898SMAD3 (directAnnotation).
CTDSPL2transfac_pro__M07461KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CTDSPL2metacluster_135.8ZNF516; ZNF536 (inferredBy_Orthology).
CTDSPL2transfac_pro__M01090SMAD9 (inferredBy_Orthology).
CTDSPL2transfac_pro__M01088DEAF1 (inferredBy_Orthology).
CTDSPL2flyfactorsurvey__Mad_FlyReg_FBgn0011648SMAD9 (inferredBy_Orthology).
CTDSPL2cisbp__M00788ZFY (inferredBy_Orthology).
CTDSPL2transfac_pro__M00430E2F1 (directAnnotation).
CTDSPL2metacluster_155.23BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CTDSPL2transfac_pro__M04893TAF1 (directAnnotation).
CTDSPL2metacluster_151.1KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CTDSPL2transfac_pro__M08894OVOL1; OVOL2 (directAnnotation).
CTDSPL2hdpi__HIP2UBE2K (directAnnotation).
CTDSPL2hdpi__TIMELESSTIMELESS (directAnnotation).
CTDSPL2metacluster_55.3E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
CTDSPL2idmmpmm__MadSMAD9 (inferredBy_Orthology).
CTDSPL2metacluster_191.5SPDEF (inferredBy_Orthology).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."