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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CTCFL

Summary for CTCFL

Gene information	Gene symbol	CTCFL
	Ensembl ID	ENSG00000124092
	Entrez ID	140690
	Gene name	CCCTC-binding factor like
	Synonyms	BORIS\|CT27\|dJ579F20.2
	Gene type	protein_coding
	UniProtAcc	Q8NI51

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Dataset with differentially expressed gene: CTCFL

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	1.59412	0.00e+00

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Expression of CTCFL in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CTCFL

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CTCFL

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CTCFL	hsa-miR-3689b-5p	95.8416	NM_001269049
CTCFL	hsa-miR-3689a-5p	95.8416	NM_001269049
CTCFL	hsa-miR-3689e	95.8416	NM_001269049
CTCFL	hsa-miR-3689f	95.8416	NM_001269049
CTCFL	hsa-miR-3123	93.4479	NM_001269046
CTCFL	hsa-miR-215-3p	93.2337	NM_001269055
CTCFL	hsa-miR-664b-3p	92.967	NM_001269040
CTCFL	hsa-miR-579-3p	92.967	NM_001269040
CTCFL	hsa-miR-3201	91.8572	NM_001269049
CTCFL	hsa-miR-4791	90.8157	NM_001269049
CTCFL	hsa-miR-4424	90.6936	NM_001269046
CTCFL	hsa-miR-5582-3p	90.3615	NM_001269048
CTCFL	hsa-miR-4704-3p	90.252	NM_001269046
CTCFL	hsa-miR-340-5p	89.3004	NM_001269048
CTCFL	hsa-miR-7110-5p	88.8016	NM_001269049
CTCFL	hsa-miR-545-5p	88.5612	NM_001269046
CTCFL	hsa-miR-6513-3p	87.3167	NM_001269046
CTCFL	hsa-miR-374b-3p	87.3071	NM_001269046
CTCFL	hsa-miR-4684-5p	86.8734	NM_001269048
CTCFL	hsa-miR-4289	86.579	NM_001269049
CTCFL	hsa-miR-6789-5p	85.6581	NM_001269046
CTCFL	hsa-miR-548e-5p	85.4246	NM_001269046
CTCFL	hsa-miR-452-5p	85.0688	NM_001269048
CTCFL	hsa-miR-4676-3p	85.0688	NM_001269048
CTCFL	hsa-miR-892c-3p	85.0688	NM_001269048
CTCFL	hsa-miR-4311	85.0279	NM_001269046
CTCFL	hsa-miR-6809-3p	84.513	NM_001269048
CTCFL	hsa-miR-6842-5p	84.4373	NM_001269049
CTCFL	hsa-miR-511-5p	84.1196	NM_001269046
CTCFL	hsa-miR-5680	82.841	NM_001269046
CTCFL	hsa-miR-6752-5p	82.2886	NM_001269049
CTCFL	hsa-miR-140-3p	82.192	NM_001269052
CTCFL	hsa-miR-488-5p	81.5752	NM_001269046
CTCFL	hsa-miR-6856-3p	81.3211	NM_001269046
CTCFL	hsa-miR-7162-5p	80.5733	NM_001269049
CTCFL	hsa-miR-516b-3p	80.5733	NM_001269049
CTCFL	hsa-miR-516a-3p	80.5733	NM_001269049
CTCFL	hsa-miR-5691	80.3645	NM_001269048
CTCFL	hsa-miR-6805-3p	80.3645	NM_001269048

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Motifs and transcription factors (TFs) regulating CTCFL

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CTCFL	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
CTCFL	metacluster_3.14	WT1; WT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."