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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CTBP2

Summary for CTBP2

Gene information	Gene symbol	CTBP2
	Ensembl ID	ENSG00000175029
	Entrez ID	1488
	Gene name	C-terminal binding protein 2
	Synonyms	ribeye
	Gene type	protein_coding
	UniProtAcc	P56545

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Dataset with differentially expressed gene: CTBP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.572562	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.297186	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.263898	5.65e-12
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.372219	1.39e-15
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.286539	3.83e-09
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.267786	9.82e-06
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.351439	0.00e+00

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Expression of CTBP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CTBP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CTBP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CTBP2	hsa-miR-95-5p	98.0283	NM_001083914
CTBP2	hsa-miR-4738-3p	96.4258	NM_001083914
CTBP2	hsa-miR-4298	96.009	NM_001083914
CTBP2	hsa-miR-1302	95.633	NM_001083914
CTBP2	hsa-miR-3913-5p	95.4371	NM_001083914
CTBP2	hsa-miR-3122	95.4342	NM_001083914
CTBP2	hsa-miR-1200	94.8588	NM_001083914
CTBP2	hsa-miR-8070	94.546	NM_001083914
CTBP2	hsa-miR-7-1-3p	93.8731	NM_001083914
CTBP2	hsa-miR-7-2-3p	93.8731	NM_001083914
CTBP2	hsa-miR-4529-5p	93.8385	NM_001083914
CTBP2	hsa-miR-198	93.7143	NM_001083914
CTBP2	hsa-miR-3059-5p	93.0014	NM_001083914
CTBP2	hsa-miR-4704-3p	92.5426	NM_001290214
CTBP2	hsa-miR-6740-5p	92.4883	NM_001083914
CTBP2	hsa-miR-3163	91.9909	NM_001083914
CTBP2	hsa-miR-6881-3p	91.4304	NM_001083914
CTBP2	hsa-miR-4324	91.1868	NM_001083914
CTBP2	hsa-miR-4680-5p	90.7055	NM_001290214
CTBP2	hsa-miR-15a-3p	90.4822	NM_001083914
CTBP2	hsa-miR-9983-3p	90.4399	NM_001083914
CTBP2	hsa-miR-5572	90.2882	NM_001290214
CTBP2	hsa-miR-643	90.0497	NM_001290214
CTBP2	hsa-miR-4772-3p	89.6032	NM_001083914
CTBP2	hsa-miR-12136	89.5247	NM_001290214
CTBP2	hsa-miR-4762-5p	88.6178	NM_001083914
CTBP2	hsa-miR-129-5p	88.257	NM_001083914
CTBP2	hsa-miR-133b	88.2345	NM_001083914
CTBP2	hsa-miR-133a-3p	88.2345	NM_001083914
CTBP2	hsa-miR-4475	87.5211	NM_001083914
CTBP2	hsa-miR-6844	87.1742	NM_001290214
CTBP2	hsa-miR-4724-5p	86.1867	NM_001290214
CTBP2	hsa-miR-10525-3p	85.8101	NM_001083914
CTBP2	hsa-miR-8485	85.6603	NM_001290214
CTBP2	hsa-miR-378a-5p	84.9968	NM_001083914
CTBP2	hsa-miR-6847-5p	84.3993	NM_001083914
CTBP2	hsa-miR-4450	84.1245	NM_001083914
CTBP2	hsa-miR-4257	83.5756	NM_001083914
CTBP2	hsa-miR-4719	83.2966	NM_001083914
CTBP2	hsa-miR-12135	83.2652	NM_001290214
CTBP2	hsa-miR-3199	82.6998	NM_001290214
CTBP2	hsa-miR-8052	82.6998	NM_001290214
CTBP2	hsa-miR-1294	82.3696	NM_001290214
CTBP2	hsa-miR-9986	82.3696	NM_001290214
CTBP2	hsa-miR-4329	82.2514	NM_001083914
CTBP2	hsa-miR-12122	82.1593	NM_001083914
CTBP2	hsa-miR-1245b-3p	81.9347	NM_001290214
CTBP2	hsa-miR-6750-3p	81.693	NM_001290214
CTBP2	hsa-miR-670-3p	81.3761	NM_001083914
CTBP2	hsa-miR-921	81.3183	NM_001083914

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Motifs and transcription factors (TFs) regulating CTBP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CTBP2	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
CTBP2	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
CTBP2	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
CTBP2	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
CTBP2	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).
CTBP2	metacluster_52.11	ZNF184 (directAnnotation).
CTBP2	metacluster_98.1	ZNF524 (directAnnotation).
CTBP2	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
CTBP2	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
CTBP2	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
CTBP2	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
CTBP2	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
CTBP2	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
CTBP2	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
CTBP2	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
CTBP2	jaspar__MA1932.1	HOXB13 (directAnnotation).
CTBP2	transfac_pro__M01298	MECP2 (directAnnotation).
CTBP2	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
CTBP2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
CTBP2	hdpi__FLI1	FLI1 (directAnnotation).
CTBP2	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
CTBP2	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
CTBP2	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
CTBP2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CTBP2	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
CTBP2	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
CTBP2	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
CTBP2	cisbp__M00808	MYPOP (inferredBy_Orthology).
CTBP2	transfac_pro__M04748	GABPA (directAnnotation).
CTBP2	metacluster_141.4	GLIS2 (directAnnotation).
CTBP2	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
CTBP2	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
CTBP2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
CTBP2	transfac_pro__M02089	E2F3 (directAnnotation).
CTBP2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CTBP2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
CTBP2	transfac_pro__M04817	ZBTB33 (directAnnotation).
CTBP2	tfdimers__MD00483	ZBTB14 (directAnnotation).
CTBP2	cisbp__M07938	E2F1 (directAnnotation).
CTBP2	cisbp__M00968	MTF2 (directAnnotation).
CTBP2	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
CTBP2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CTBP2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."