Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CSRP2

Summary for CSRP2

Gene information	Gene symbol	CSRP2
	Ensembl ID	ENSG00000175183
	Entrez ID	1466
	Gene name	cysteine and glycine rich protein 2
	Synonyms	CRP2\|LMO5\|SmLIM
	Gene type	protein_coding
	UniProtAcc	Q16527

Top

Dataset with differentially expressed gene: CSRP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.389408	1.50e-34
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.4771	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.620178	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.920878	0.00e+00

Top

Expression of CSRP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to CSRP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating CSRP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CSRP2	hsa-miR-27b-3p	95.4016	NM_001300965
CSRP2	hsa-miR-27a-3p	95.4016	NM_001300965
CSRP2	hsa-miR-9985	95.4016	NM_001300965
CSRP2	hsa-miR-101-3p	93.5006	NM_001300965
CSRP2	hsa-miR-6889-3p	92.4759	NM_001321
CSRP2	hsa-miR-4495	91.6667	NM_001321
CSRP2	hsa-miR-138-5p	89.3523	NM_001321
CSRP2	hsa-miR-199b-3p	89.168	NM_001300965
CSRP2	hsa-miR-199a-3p	89.168	NM_001300965
CSRP2	hsa-miR-3129-5p	89.168	NM_001300965
CSRP2	hsa-miR-6529-3p	88.4247	NM_001321
CSRP2	hsa-miR-6867-5p	84.9447	NM_001321
CSRP2	hsa-miR-1244	83.2991	NM_001300965
CSRP2	hsa-miR-128-3p	82.0433	NM_001300965
CSRP2	hsa-miR-216a-3p	82.0433	NM_001300965
CSRP2	hsa-miR-133a-5p	81.9176	NM_001321
CSRP2	hsa-miR-122b-5p	81.1518	NM_001321

Page: 1

Top

Motifs and transcription factors (TFs) regulating CSRP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CSRP2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
CSRP2	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
CSRP2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
CSRP2	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
CSRP2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
CSRP2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
CSRP2	metacluster_3.14	WT1; WT1 (directAnnotation).
CSRP2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
CSRP2	cisbp__M07938	E2F1 (directAnnotation).
CSRP2	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
CSRP2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
CSRP2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CSRP2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
CSRP2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
CSRP2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
CSRP2	transfac_pro__M04866	HDAC2 (directAnnotation).
CSRP2	jaspar__MA1122.1	TFDP1 (directAnnotation).
CSRP2	metacluster_135.11	NR2C2 (directAnnotation).
CSRP2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CSRP2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CSRP2	metacluster_7.13	ZFX (directAnnotation).
CSRP2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CSRP2	cisbp__M00968	MTF2 (directAnnotation).
CSRP2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CSRP2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
CSRP2	metacluster_198.3	ZFP64 (directAnnotation).
CSRP2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CSRP2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CSRP2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CSRP2	cisbp__M00788	ZFY (inferredBy_Orthology).
CSRP2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
CSRP2	metacluster_175.1	ZNF283 (directAnnotation).
CSRP2	hdpi__ZNF304	ZNF304 (directAnnotation).
CSRP2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
CSRP2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
CSRP2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CSRP2	transfac_pro__M01199	TRIM28 (directAnnotation).
CSRP2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
CSRP2	metacluster_151.2	ZNF23 (directAnnotation).
CSRP2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CSRP2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CSRP2	transfac_pro__M03806	ZBTB7C (directAnnotation).
CSRP2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CSRP2	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
CSRP2	transfac_pro__M04918	EGR1 (directAnnotation).
CSRP2	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
CSRP2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
CSRP2	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
CSRP2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CSRP2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."