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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CSRNP1

Summary for CSRNP1

Gene information	Gene symbol	CSRNP1
	Ensembl ID	ENSG00000144655
	Entrez ID	64651
	Gene name	cysteine and serine rich nuclear protein 1
	Synonyms	AXUD1\|DKFZp566F164\|FAM130B\|TAIP-3\|URAX1
	Gene type	protein_coding
	UniProtAcc	Q96S65

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Dataset with differentially expressed gene: CSRNP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.271187	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	0.435124	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD4+ T cells	0.373185	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	0.520605	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.29099	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	-0.462917	3.45e-04
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.552526	9.52e-41
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-1.09661	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.800322	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.321718	2.34e-07
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.392919	4.06e-11
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.274828	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	CD8+ T cells	-0.292214	1.27e-24
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.484095	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.595047	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	0.437672	3.27e-08
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	0.294883	4.75e-10

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Expression of CSRNP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CSRNP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CSRNP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CSRNP1	hsa-miR-6721-5p	96.7757	NM_001320560
CSRNP1	hsa-miR-1266-5p	95.5471	NM_001320559
CSRNP1	hsa-miR-486-3p	95.0668	NM_001320560
CSRNP1	hsa-miR-7-2-3p	95.0541	NM_001320560
CSRNP1	hsa-miR-7-1-3p	95.0541	NM_001320560
CSRNP1	hsa-miR-4518	94.4388	NM_001320559
CSRNP1	hsa-miR-3688-3p	93.7272	NM_001320559
CSRNP1	hsa-miR-519d-5p	92.7971	NM_001320559
CSRNP1	hsa-miR-1322	91.9945	NM_001320559
CSRNP1	hsa-miR-6505-5p	90.3336	NM_001320560
CSRNP1	hsa-miR-6838-5p	89.6191	NM_001320560
CSRNP1	hsa-miR-424-5p	89.6191	NM_001320560
CSRNP1	hsa-miR-195-5p	89.6191	NM_001320560
CSRNP1	hsa-miR-15a-5p	89.6191	NM_001320560
CSRNP1	hsa-miR-497-5p	89.6191	NM_001320560
CSRNP1	hsa-miR-15b-5p	89.6191	NM_001320560
CSRNP1	hsa-miR-16-5p	89.6191	NM_001320560
CSRNP1	hsa-miR-211-3p	89.0597	NM_001320559
CSRNP1	hsa-miR-5587-5p	88.6465	NM_001320560
CSRNP1	hsa-miR-3934-3p	84.7338	NM_001320559
CSRNP1	hsa-miR-939-3p	83.0746	NM_001320559
CSRNP1	hsa-miR-515-5p	82.7886	NM_001320559
CSRNP1	hsa-miR-519e-5p	82.7886	NM_001320559
CSRNP1	hsa-miR-4319	81.8082	NM_001320560
CSRNP1	hsa-miR-3668	81.2436	NM_001320559
CSRNP1	hsa-miR-548ao-3p	81.239	NM_001320559

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Motifs and transcription factors (TFs) regulating CSRNP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CSRNP1	tfdimers__MD00225	NKX6-2; POU5F1 (directAnnotation).
CSRNP1	metacluster_145.6	ZNF79; ZNF79 (directAnnotation).
CSRNP1	tfdimers__MD00454	ARID3A; PAX4 (directAnnotation).
CSRNP1	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
CSRNP1	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
CSRNP1	metacluster_32.24	ZNF287 (directAnnotation).
CSRNP1	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
CSRNP1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
CSRNP1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
CSRNP1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
CSRNP1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CSRNP1	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
CSRNP1	transfac_pro__M01303	SP1 (directAnnotation).
CSRNP1	transfac_pro__M07329	SP7 (directAnnotation).
CSRNP1	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
CSRNP1	tfdimers__MD00377	PBX1 (directAnnotation).
CSRNP1	tfdimers__MD00595	SREBF1; SREBF2; TBP (directAnnotation).
CSRNP1	tfdimers__MD00232	CEBPB; TAF6; TBP (directAnnotation).
CSRNP1	swissregulon__hs__FOXO3	FOXO3 (directAnnotation).
CSRNP1	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
CSRNP1	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
CSRNP1	tfdimers__MD00143	IKZF1; MZF1 (directAnnotation).
CSRNP1	tfdimers__MD00026	IRF1; MYB (directAnnotation).
CSRNP1	transfac_pro__M01239	RELA (directAnnotation).
CSRNP1	swissregulon__hs__RUNX2	RUNX2 (directAnnotation).
CSRNP1	taipale_tf_pairs__TEAD4_SOX15_NACAATRNNNNNGAATGY_CAP_repr	SOX15; TEAD4 (directAnnotation).
CSRNP1	taipale_tf_pairs__FOXJ2_HOXB13_RTAAACWNATWAAA_CAP_repr	FOXJ2; HOXB13 (directAnnotation).
CSRNP1	metacluster_22.33	MAFK (inferredBy_Orthology).
CSRNP1	transfac_pro__M04706	RELA (directAnnotation).
CSRNP1	taipale_tf_pairs__ERF_SREBF2_NNCACGTGACMGGAARNN_CAP_repr	ERF; SREBF2 (directAnnotation).
CSRNP1	taipale_tf_pairs__MYBL1_TBX21_AGGTGTGNCSGTTR_CAP_repr	MYBL1; TBX21 (directAnnotation).
CSRNP1	kznf__ZNF45_Imbeault2017_OM_RCADE	ZNF45 (directAnnotation).
CSRNP1	transfac_pro__M06826	ZNF516 (inferredBy_Orthology).
CSRNP1	tfdimers__MD00036	FOS; FOSB; FOSL1; FOSL2; ILF2; JUN; JUNB; JUND; NFATC2 (directAnnotation).
CSRNP1	transfac_pro__M12441	ZNF281 (inferredBy_Orthology).
CSRNP1	transfac_pro__M06856	ZNF611 (directAnnotation).
CSRNP1	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
CSRNP1	kznf__ZNF382_Najafabadi2015_ChIP-seq	ZNF382 (directAnnotation).
CSRNP1	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
CSRNP1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CSRNP1	transfac_pro__M07397	ZNF148 (directAnnotation).
CSRNP1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CSRNP1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
CSRNP1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CSRNP1	transfac_pro__M07436	WT1 (directAnnotation).
CSRNP1	metacluster_3.14	WT1; WT1 (directAnnotation).
CSRNP1	swissregulon__hs__KLF6	KLF6 (directAnnotation).
CSRNP1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
CSRNP1	metacluster_52.13	LEF1; LEF1; LEF1; LEF1; TCF7; TCF7; TCF7L1; TCF7L1 (directAnnotation).
CSRNP1	dbtfbs__ZNF664_HEK293_ENCSR714LZQ_merged_N1	ZNF664 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."