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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CSNK2A1

Summary for CSNK2A1

Gene information	Gene symbol	CSNK2A1
	Ensembl ID	ENSG00000101266
	Entrez ID	1457
	Gene name	casein kinase 2 alpha 1
	Synonyms	Cka1\|Cka2
	Gene type	protein_coding
	UniProtAcc	P68400

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Dataset with differentially expressed gene: CSNK2A1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.640086	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.326482	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.871774	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.310861	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.443176	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.479412	0.00e+00

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Expression of CSNK2A1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CSNK2A1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CSNK2A1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CSNK2A1	hsa-miR-4724-5p	95.2412	NM_001895
CSNK2A1	hsa-miR-12113	93.9289	NM_001895
CSNK2A1	hsa-miR-4539	93.9289	NM_001895
CSNK2A1	hsa-miR-6739-3p	93.1701	NM_001895
CSNK2A1	hsa-miR-4677-5p	93.0297	NM_001895
CSNK2A1	hsa-miR-518c-5p	91.2086	NM_001895
CSNK2A1	hsa-miR-1229-5p	90.7551	NM_001895
CSNK2A1	hsa-miR-548t-3p	90.65	NM_001895
CSNK2A1	hsa-miR-548ap-3p	90.65	NM_001895
CSNK2A1	hsa-miR-548aa	90.65	NM_001895
CSNK2A1	hsa-miR-571	90.6193	NM_001895
CSNK2A1	hsa-miR-188-3p	90.6178	NM_001895
CSNK2A1	hsa-miR-6514-5p	89.7014	NM_001895
CSNK2A1	hsa-miR-7706	88.4369	NM_001895
CSNK2A1	hsa-miR-5011-5p	88.1099	NM_001895
CSNK2A1	hsa-miR-4444	86.5974	NM_001895
CSNK2A1	hsa-miR-12128	84.729	NM_001895
CSNK2A1	hsa-miR-4516	84.5731	NM_001895
CSNK2A1	hsa-miR-20a-3p	84.2412	NM_001895
CSNK2A1	hsa-miR-6883-5p	84.1417	NM_001895
CSNK2A1	hsa-miR-3928-3p	83.3919	NM_001895
CSNK2A1	hsa-miR-8485	83.0615	NM_001895
CSNK2A1	hsa-miR-3175	82.9113	NM_001895
CSNK2A1	hsa-miR-190a-3p	82.6187	NM_001895
CSNK2A1	hsa-miR-548e-5p	82.5623	NM_001895
CSNK2A1	hsa-miR-4728-5p	81.5089	NM_001895
CSNK2A1	hsa-miR-6785-5p	81.5089	NM_001895
CSNK2A1	hsa-miR-4288	81.2361	NM_001895
CSNK2A1	hsa-miR-1252-3p	81.0496	NM_001895
CSNK2A1	hsa-miR-641	80.6739	NM_001895
CSNK2A1	hsa-miR-3617-5p	80.6739	NM_001895
CSNK2A1	hsa-miR-548n	80.0631	NM_001895

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Motifs and transcription factors (TFs) regulating CSNK2A1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CSNK2A1	metacluster_7.13	ZFX (directAnnotation).
CSNK2A1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
CSNK2A1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
CSNK2A1	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
CSNK2A1	metacluster_151.2	ZNF23 (directAnnotation).
CSNK2A1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CSNK2A1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CSNK2A1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
CSNK2A1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CSNK2A1	hdpi__ETV4	ETV4 (directAnnotation).
CSNK2A1	transfac_pro__M06071	ZNF814 (directAnnotation).
CSNK2A1	jaspar__MA0748.2	YY2 (directAnnotation).
CSNK2A1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
CSNK2A1	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
CSNK2A1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CSNK2A1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CSNK2A1	transfac_pro__M07397	ZNF148 (directAnnotation).
CSNK2A1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
CSNK2A1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
CSNK2A1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
CSNK2A1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CSNK2A1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
CSNK2A1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
CSNK2A1	transfac_pro__M01175	ZBTB7B (directAnnotation).
CSNK2A1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CSNK2A1	tfdimers__MD00151	CHURC1 (directAnnotation).
CSNK2A1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CSNK2A1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CSNK2A1	transfac_pro__M01303	SP1 (directAnnotation).
CSNK2A1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CSNK2A1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CSNK2A1	transfac_pro__M01714	KLF15 (directAnnotation).
CSNK2A1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CSNK2A1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
CSNK2A1	transfac_pro__M02089	E2F3 (directAnnotation).
CSNK2A1	metacluster_3.14	WT1; WT1 (directAnnotation).
CSNK2A1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
CSNK2A1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
CSNK2A1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
CSNK2A1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
CSNK2A1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CSNK2A1	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
CSNK2A1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
CSNK2A1	transfac_pro__M07436	WT1 (directAnnotation).
CSNK2A1	transfac_pro__M02281	SP1 (directAnnotation).
CSNK2A1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
CSNK2A1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CSNK2A1	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
CSNK2A1	transfac_pro__M02898	SMAD3 (directAnnotation).
CSNK2A1	transfac_public__M00491	PATZ1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CSNK2A1	"(5-hydroxyindolo[1,2-a]quinazolin-7-yl)acetic acid"	DB01765	small molecule
CSNK2A1	"1,8-Di-Hydroxy-4-Nitro-Anthraquinone"	DB03035	small molecule
CSNK2A1	"1,8-Di-Hydroxy-4-Nitro-Xanthen-9-One"	DB02170	small molecule
CSNK2A1	"19-(cyclopropylamino)-4,6,7,15-tetrahydro-5H-16,1-(azenometheno)-10,14-(metheno)pyrazolo[4,3-o][1,3	DB08338	small molecule
CSNK2A1	"2-(4-CHLOROBENZYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE"	DB08354	small molecule
CSNK2A1	"2-(4-ETHYLPIPERAZIN-1-YL)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE"	DB08360	small molecule
CSNK2A1	"2-(CYCLOHEXYLMETHYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE"	DB08353	small molecule
CSNK2A1	"3,8-DIBROMO-7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE"	DB07802	small molecule
CSNK2A1	"4-(2-(1H-IMIDAZOL-4-YL)ETHYLAMINO)-2-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE"	DB08345	small molecule
CSNK2A1	"5,8-Di-Amino-1,4-Dihydroxy-Anthraquinone"	DB03924	small molecule
CSNK2A1	"ATP"	DB00171	small molecule
CSNK2A1	"Benzamidine"	DB03127	small molecule
CSNK2A1	"Dichlororibofuranosylbenzimidazole"	DB08473	small molecule
CSNK2A1	"DIMETHYL-(4,5,6,7-TETRABROMO-1H-BENZOIMIDAZOL-2-YL)-AMINE"	DB04719	small molecule
CSNK2A1	"Ellagic acid"	DB08846	small molecule
CSNK2A1	"Emodin"	DB07715	small molecule
CSNK2A1	"Fostamatinib"	DB12010	small molecule
CSNK2A1	"N,N'-DIPHENYLPYRAZOLO[1,5-A][1,3,5]TRIAZINE-2,4-DIAMINE"	DB08340	small molecule
CSNK2A1	"N-(3-(8-CYANO-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-2-YLAMINO)PHENYL)ACETAMIDE"	DB08362	small molecule
CSNK2A1	"N1,N2-ETHYLENE-2-METHYLAMINO-4,5,6,7-TETRABROMO-BENZIMIDAZOLE"	DB04721	small molecule
CSNK2A1	"Phosphoaminophosphonic Acid-Adenylate Ester"	DB04395	small molecule
CSNK2A1	"Quercetin"	DB04216	small molecule
CSNK2A1	"Quinalizarin"	DB08660	small molecule
CSNK2A1	"Resveratrol"	DB02709	small molecule
CSNK2A1	"S-METHYL-4,5,6,7-TETRABROMO-BENZIMIDAZOLE"	DB04720	small molecule
CSNK2A1	"Tetrabromo-2-Benzotriazole"	DB04462	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."