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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CSNK1G3

Summary for CSNK1G3

Gene information	Gene symbol	CSNK1G3
	Ensembl ID	ENSG00000151292
	Entrez ID	1456
	Gene name	casein kinase 1 gamma 3
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q9Y6M4

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Dataset with differentially expressed gene: CSNK1G3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.3247	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.353103	2.57e-30

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Expression of CSNK1G3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CSNK1G3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CSNK1G3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CSNK1G3	hsa-miR-137-3p	99.7505	NM_001031812
CSNK1G3	hsa-miR-545-3p	98.5094	NM_001031812
CSNK1G3	hsa-miR-5587-5p	97.8593	NM_001031812
CSNK1G3	hsa-miR-23b-3p	97.8407	NM_001031812
CSNK1G3	hsa-miR-23a-3p	97.8407	NM_001031812
CSNK1G3	hsa-miR-23c	97.8407	NM_001031812
CSNK1G3	hsa-miR-2115-5p	97.5354	NM_001031812
CSNK1G3	hsa-miR-10527-5p	96.9942	NM_001031812
CSNK1G3	hsa-miR-200c-3p	96.5336	NM_001031812
CSNK1G3	hsa-miR-200b-3p	96.5336	NM_001031812
CSNK1G3	hsa-miR-429	96.5336	NM_001031812
CSNK1G3	hsa-miR-4251	95.5769	NM_001031812
CSNK1G3	hsa-miR-330-3p	95.3022	NM_001031812
CSNK1G3	hsa-miR-6828-5p	95.0829	NM_001031812
CSNK1G3	hsa-miR-1185-1-3p	95.0788	NM_001031812
CSNK1G3	hsa-miR-1185-2-3p	95.0788	NM_001031812
CSNK1G3	hsa-let-7f-2-3p	95.0788	NM_001031812
CSNK1G3	hsa-miR-133a-3p	95.074	NM_001031812
CSNK1G3	hsa-miR-133b	95.074	NM_001031812
CSNK1G3	hsa-miR-3125	94.3829	NM_001031812
CSNK1G3	hsa-miR-6079	94.3669	NM_001031812
CSNK1G3	hsa-miR-5100	94.0893	NM_001031812
CSNK1G3	hsa-miR-3916	94.0551	NM_001031812
CSNK1G3	hsa-miR-6859-5p	94.0551	NM_001031812
CSNK1G3	hsa-miR-4698	93.1014	NM_001031812
CSNK1G3	hsa-miR-1248	92.2213	NM_001031812
CSNK1G3	hsa-miR-29b-2-5p	92.1516	NM_001031812
CSNK1G3	hsa-miR-361-5p	90.7782	NM_001031812
CSNK1G3	hsa-miR-7106-5p	90.7364	NM_001031812
CSNK1G3	hsa-miR-6516-5p	90.225	NM_001031812
CSNK1G3	hsa-miR-1303	89.9022	NM_001031812
CSNK1G3	hsa-miR-877-5p	89.7222	NM_001031812
CSNK1G3	hsa-miR-548c-3p	89.657	NM_001031812
CSNK1G3	hsa-miR-12135	89.0126	NM_001031812
CSNK1G3	hsa-miR-671-5p	87.7179	NM_001031812
CSNK1G3	hsa-miR-548e-5p	87.5188	NM_001031812
CSNK1G3	hsa-miR-9-3p	87.1807	NM_001031812
CSNK1G3	hsa-miR-1301-3p	87.0662	NM_001031812
CSNK1G3	hsa-miR-5047	87.0662	NM_001031812
CSNK1G3	hsa-miR-2052	86.9769	NM_001031812
CSNK1G3	hsa-miR-12123	86.937	NM_001031812
CSNK1G3	hsa-miR-935	86.8837	NM_001031812
CSNK1G3	hsa-miR-3926	86.5593	NM_001031812
CSNK1G3	hsa-miR-587	86.505	NM_001031812
CSNK1G3	hsa-let-7c-3p	86.4091	NM_001031812
CSNK1G3	hsa-miR-3680-3p	86.1587	NM_001031812
CSNK1G3	hsa-miR-4676-5p	86.0008	NM_001031812
CSNK1G3	hsa-miR-575	86.0008	NM_001031812
CSNK1G3	hsa-miR-3646	85.8224	NM_001031812
CSNK1G3	hsa-miR-4803	85.7414	NM_001031812

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Motifs and transcription factors (TFs) regulating CSNK1G3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CSNK1G3	metacluster_135.11	NR2C2 (directAnnotation).
CSNK1G3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CSNK1G3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CSNK1G3	metacluster_7.13	ZFX (directAnnotation).
CSNK1G3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CSNK1G3	cisbp__M00968	MTF2 (directAnnotation).
CSNK1G3	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CSNK1G3	metacluster_160.20	JUND; PRDM15 (directAnnotation).
CSNK1G3	cisbp__M00341	PAX6 (directAnnotation).
CSNK1G3	metacluster_198.3	ZFP64 (directAnnotation).
CSNK1G3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CSNK1G3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CSNK1G3	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
CSNK1G3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CSNK1G3	cisbp__M00788	ZFY (inferredBy_Orthology).
CSNK1G3	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
CSNK1G3	metacluster_175.1	ZNF283 (directAnnotation).
CSNK1G3	hdpi__ZNF304	ZNF304 (directAnnotation).
CSNK1G3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
CSNK1G3	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
CSNK1G3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CSNK1G3	transfac_pro__M01199	TRIM28 (directAnnotation).
CSNK1G3	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
CSNK1G3	metacluster_151.2	ZNF23 (directAnnotation).
CSNK1G3	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CSNK1G3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CSNK1G3	transfac_pro__M03806	ZBTB7C (directAnnotation).
CSNK1G3	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CSNK1G3	jaspar__MA0748.2	YY2 (directAnnotation).
CSNK1G3	cisbp__M01863	ZNF711 (inferredBy_Orthology).
CSNK1G3	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CSNK1G3	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
CSNK1G3	hdpi__TIMELESS	TIMELESS (directAnnotation).
CSNK1G3	metacluster_191.5	SPDEF (inferredBy_Orthology).
CSNK1G3	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
CSNK1G3	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
CSNK1G3	transfac_pro__M02913	SP140 (inferredBy_Orthology).
CSNK1G3	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
CSNK1G3	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
CSNK1G3	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
CSNK1G3	hdpi__ELF2	ELF2 (directAnnotation).
CSNK1G3	tfdimers__MD00038	TFAP2C (directAnnotation).
CSNK1G3	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
CSNK1G3	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CSNK1G3	"4-Amino-2-[(3-chlorophenyl)amino]-5-(4-fluorobenzoyl)-1,3-thiazol-3-ium"	DB07489	small molecule
CSNK1G3	"K-00546"	DB07664	small molecule
CSNK1G3	"Purvalanol A"	DB04751	small molecule
CSNK1G3	"{4-Amino-2-[(4-methoxyphenyl)amino]-1,3-thiazol-5-yl}(4-methoxyphenyl)methanone"	DB07488	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."