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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CSNK1G2

Summary for CSNK1G2

Gene information	Gene symbol	CSNK1G2
	Ensembl ID	ENSG00000133275
	Entrez ID	1455
	Gene name	casein kinase 1 gamma 2
	Synonyms	CK1g2
	Gene type	protein_coding
	UniProtAcc	P78368

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Dataset with differentially expressed gene: CSNK1G2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.304495	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.567123	2.74e-02
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.271069	6.43e-11

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Expression of CSNK1G2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CSNK1G2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CSNK1G2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CSNK1G2	hsa-miR-6769a-3p	94.9113	NM_001319
CSNK1G2	hsa-miR-155-5p	92.8224	NM_001319
CSNK1G2	hsa-miR-103a-3p	90.0366	NM_001319
CSNK1G2	hsa-miR-107	90.0366	NM_001319
CSNK1G2	hsa-miR-29b-2-5p	87.1306	NM_001319
CSNK1G2	hsa-miR-4422	84.3889	NM_001319
CSNK1G2	hsa-miR-6835-3p	84.3889	NM_001319
CSNK1G2	hsa-miR-135a-5p	82.8629	NM_001319
CSNK1G2	hsa-miR-135b-5p	82.8629	NM_001319

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Motifs and transcription factors (TFs) regulating CSNK1G2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CSNK1G2	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
CSNK1G2	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
CSNK1G2	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
CSNK1G2	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
CSNK1G2	hdpi__FLI1	FLI1 (directAnnotation).
CSNK1G2	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
CSNK1G2	jaspar__MA1935.1	FOXI1 (directAnnotation).
CSNK1G2	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
CSNK1G2	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
CSNK1G2	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
CSNK1G2	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
CSNK1G2	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
CSNK1G2	taipale_cyt_meth__CDX2_NRTCGTAAANNN_eDBD_meth	CDX2 (directAnnotation).
CSNK1G2	metacluster_183.3	EHF; ELF3; FLI1; SPIB (directAnnotation). EHF; EHF; ELF2; ELF3; ELF4; ELF5; ERG; ERG; ETV3; ETV6; FLI1; SPI1; SPI1 (inferredBy_Orthology).
CSNK1G2	metacluster_161.2	LHX8 (directAnnotation).
CSNK1G2	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
CSNK1G2	metacluster_183.4	ETS1 (inferredBy_Orthology).
CSNK1G2	transfac_pro__M01253	CNOT3 (directAnnotation).
CSNK1G2	transfac_pro__M02896	SPI1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CSNK1G2	"5-iodotubercidin"	DB04604	small molecule
CSNK1G2	"IC261"	DB03083	small molecule
CSNK1G2	"N-(2-Aminoethyl)-5-Chloroisoquinoline-8-Sulfonamide"	DB03693	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."