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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CSNK1D

Summary for CSNK1D

Gene information	Gene symbol	CSNK1D
	Ensembl ID	ENSG00000141551
	Entrez ID	1453
	Gene name	casein kinase 1 delta
	Synonyms	CKID\|CKIdelta\|HCKID
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CSNK1D

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.327856	5.41e-17
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.269473	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.542845	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.302198	6.97e-34
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.32309	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.336123	0.00e+00

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Expression of CSNK1D in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CSNK1D

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CSNK1D

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CSNK1D	hsa-miR-4672	98.0422	NM_139062
CSNK1D	hsa-miR-3941	93.6844	NM_139062
CSNK1D	hsa-miR-4297	92.7587	NM_139062
CSNK1D	hsa-miR-466	91.8293	NM_139062
CSNK1D	hsa-miR-548av-5p	91.2239	NM_139062
CSNK1D	hsa-miR-8054	91.2239	NM_139062
CSNK1D	hsa-miR-548k	91.2239	NM_139062
CSNK1D	hsa-miR-374b-3p	91.1017	NM_139062
CSNK1D	hsa-miR-6882-3p	89.6828	NM_139062
CSNK1D	hsa-miR-548p	89.5658	NM_139062
CSNK1D	hsa-miR-4270	89.2159	NM_139062
CSNK1D	hsa-miR-5581-5p	88.6348	NM_139062
CSNK1D	hsa-miR-4441	86.4057	NM_139062
CSNK1D	hsa-miR-4698	86.3053	NM_139062
CSNK1D	hsa-miR-559	84.8672	NM_139062
CSNK1D	hsa-miR-4801	84.1935	NM_139062
CSNK1D	hsa-miR-6849-3p	83.826	NM_001893
CSNK1D	hsa-miR-95-5p	83.7823	NM_001893
CSNK1D	hsa-miR-18a-3p	83.1922	NM_001893
CSNK1D	hsa-miR-3135a	81.6194	NM_001893
CSNK1D	hsa-miR-6730-5p	81.3917	NM_001893
CSNK1D	hsa-miR-7977	81.197	NM_139062
CSNK1D	hsa-miR-4731-3p	80.4396	NM_139062
CSNK1D	hsa-miR-4288	80.3801	NM_001893
CSNK1D	hsa-miR-4294	80.3342	NM_139062
CSNK1D	hsa-miR-548ae-5p	80.331	NM_139062
CSNK1D	hsa-miR-548c-5p	80.331	NM_139062
CSNK1D	hsa-miR-548a-5p	80.331	NM_139062
CSNK1D	hsa-miR-548au-5p	80.331	NM_139062
CSNK1D	hsa-miR-548ay-5p	80.331	NM_139062
CSNK1D	hsa-miR-548i	80.331	NM_139062
CSNK1D	hsa-miR-548b-5p	80.331	NM_139062
CSNK1D	hsa-miR-548bb-5p	80.331	NM_139062
CSNK1D	hsa-miR-548as-5p	80.331	NM_139062
CSNK1D	hsa-miR-548o-5p	80.331	NM_139062
CSNK1D	hsa-miR-548aq-5p	80.331	NM_139062
CSNK1D	hsa-miR-548ap-5p	80.331	NM_139062
CSNK1D	hsa-miR-548y	80.331	NM_139062
CSNK1D	hsa-miR-548d-5p	80.331	NM_139062
CSNK1D	hsa-miR-548ak	80.331	NM_139062
CSNK1D	hsa-miR-548ad-5p	80.331	NM_139062
CSNK1D	hsa-miR-548h-5p	80.331	NM_139062
CSNK1D	hsa-miR-548j-5p	80.331	NM_139062
CSNK1D	hsa-miR-548ab	80.331	NM_139062
CSNK1D	hsa-miR-548am-5p	80.331	NM_139062
CSNK1D	hsa-miR-548w	80.331	NM_139062
CSNK1D	hsa-miR-548ar-5p	80.331	NM_139062
CSNK1D	hsa-miR-548l	80.331	NM_139062
CSNK1D	hsa-miR-4766-3p	80.2005	NM_139062

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Motifs and transcription factors (TFs) regulating CSNK1D

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CSNK1D	metacluster_151.2	ZNF23 (directAnnotation).
CSNK1D	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CSNK1D	transfac_pro__M05628	ZNF735 (directAnnotation).
CSNK1D	jaspar__MA0079.5	SP1 (directAnnotation).
CSNK1D	transfac_pro__M07397	ZNF148 (directAnnotation).
CSNK1D	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
CSNK1D	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
CSNK1D	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
CSNK1D	transfac_pro__M01175	ZBTB7B (directAnnotation).
CSNK1D	tfdimers__MD00151	CHURC1 (directAnnotation).
CSNK1D	transfac_pro__M01303	SP1 (directAnnotation).
CSNK1D	transfac_pro__M01714	KLF15 (directAnnotation).
CSNK1D	transfac_pro__M02281	SP1 (directAnnotation).
CSNK1D	transfac_public__M00491	PATZ1 (directAnnotation).
CSNK1D	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
CSNK1D	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
CSNK1D	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
CSNK1D	hdpi__FLI1	FLI1 (directAnnotation).
CSNK1D	jaspar__MA0748.2	YY2 (directAnnotation).
CSNK1D	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
CSNK1D	jaspar__MA1721.1	ZNF93 (directAnnotation).
CSNK1D	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CSNK1D	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
CSNK1D	transfac_pro__M01973	PLAG1 (directAnnotation).
CSNK1D	cisbp__M00249	WT1 (directAnnotation).
CSNK1D	transfac_pro__M01122	ZNF219 (directAnnotation).
CSNK1D	tfdimers__MD00391	KLF4 (directAnnotation).
CSNK1D	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."