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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CSF3R

Summary for CSF3R

Gene information	Gene symbol	CSF3R
	Ensembl ID	ENSG00000119535
	Entrez ID	1441
	Gene name	colony stimulating factor 3 receptor
	Synonyms	CD114\|GCSFR
	Gene type	protein_coding
	UniProtAcc	Q99062

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Dataset with differentially expressed gene: CSF3R

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.31386	1.06e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.668655	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.465078	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	cDCs	0.454386	2.66e-13
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.436705	1.32e-10
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.288135	2.30e-04
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.553813	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	-0.34577	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Mono/Macro	-0.377277	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	0.529338	0.00e+00

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Expression of CSF3R in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CSF3R

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
CSF3R	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating CSF3R

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CSF3R	hsa-miR-7152-3p	95.4452	NM_156039
CSF3R	hsa-miR-6780a-5p	92.383	NM_000760
CSF3R	hsa-miR-3689b-3p	87.7249	NM_000760
CSF3R	hsa-miR-3689a-3p	87.7249	NM_000760
CSF3R	hsa-miR-1273h-5p	87.7249	NM_000760
CSF3R	hsa-miR-3689c	87.7249	NM_000760
CSF3R	hsa-miR-6779-5p	87.7249	NM_000760
CSF3R	hsa-miR-30b-3p	87.7249	NM_000760
CSF3R	hsa-miR-4650-5p	82.6657	NM_156039

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Motifs and transcription factors (TFs) regulating CSF3R

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CSF3R	homer__ATTGCGCAAC_CEBP	CEBPB (inferredBy_Orthology).
CSF3R	metacluster_46.4	CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; DBP; DBP; EP300; GATAD2A; HES2 (directAnnotation). CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; HLF; HLF (inferredBy_Orthology).
CSF3R	transfac_pro__M06342	ZNF329 (inferredBy_Orthology).
CSF3R	transfac_pro__M04761	HSF1 (directAnnotation).
CSF3R	metacluster_156.3	DBP; DBP; DBP; DBP; DBP; DBP; DBP; DBP; HLF; HLF; HLF; HLF; HLF; HLF; HLF; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; TEF; TEF; TEF; TEF; TEF (directAnnotation). DBP; DBP; DBP; DBP; DBP; HLF; HLF; HLF; HLF; HLF; NFIL3; NFIL3; NFILZ; NFILZ; TEF; TEF; TEF; TEF (inferredBy_Orthology).
CSF3R	transfac_pro__M05469	SALL1 (directAnnotation).
CSF3R	metacluster_168.11	ZNF771; ZNF771 (directAnnotation).
CSF3R	taipale_cyt_meth__VENTX_CGATTATCG_FL_repr	VENTX (directAnnotation).
CSF3R	metacluster_46.5	HLF; TEF (directAnnotation).
CSF3R	metacluster_194.1	BARHL1; BARHL2; BARHL2; BARHL2; ZNF354A; ZNF354A (directAnnotation). BARHL1 (inferredBy_Orthology).
CSF3R	metacluster_143.19	PLAGL2; ZNF740 (directAnnotation).
CSF3R	tfdimers__MD00038	TFAP2C (directAnnotation).
CSF3R	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CSF3R	cisbp__M00341	PAX6 (directAnnotation).
CSF3R	swissregulon__hs__PATZ1	PATZ1 (directAnnotation).
CSF3R	taipale_tf_pairs__ELK1_SPDEF_NSMGGACGGAYNTCCKSN_CAP	ELK1; SPDEF (directAnnotation).
CSF3R	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
CSF3R	transfac_pro__M06313	ZNF678 (directAnnotation).
CSF3R	tfdimers__MD00123	E2F1; SOX17 (directAnnotation).
CSF3R	taipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAP	ETV2; SPDEF (directAnnotation).
CSF3R	transfac_pro__M12556	ETV4 (directAnnotation).
CSF3R	taipale_tf_pairs__ETV2_CEBPD_RSCGGANNTTGCGYAAN_CAP_repr	CEBPD; ETV2 (directAnnotation).
CSF3R	metacluster_131.11	ZNF746 (directAnnotation).
CSF3R	transfac_pro__M05890	ZNF274 (directAnnotation).
CSF3R	transfac_pro__M05612	ZNF189 (directAnnotation).
CSF3R	metacluster_113.5	OVOL1; OVOL1; OVOL2; OVOL2; OVOL2; OVOL2 (directAnnotation). OVOL1; OVOL1; OVOL1 (inferredBy_Orthology).
CSF3R	tfdimers__MD00217	LTF; MZF1 (directAnnotation).
CSF3R	hocomoco__FOXP1_HUMAN.H11MO.0.A	FOXP1 (directAnnotation).
CSF3R	transfac_pro__M06467	ZNF695 (directAnnotation).
CSF3R	transfac_pro__M06133	ZNF17 (directAnnotation).
CSF3R	transfac_pro__M04706	RELA (directAnnotation).
CSF3R	cisbp__M01815	CEBPE (inferredBy_Orthology).
CSF3R	jaspar__MA1954.1	FOXO1 (directAnnotation).
CSF3R	metacluster_5.1	HIVEP1; HIVEP1; NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; NFKB2; NFKB2; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELB; RELB (directAnnotation). NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; REL; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELB; RELB; RELB (inferredBy_Orthology).
CSF3R	transfac_pro__M04746	E2F1 (directAnnotation).
CSF3R	metacluster_119.2	CCNT2; GATA1; GATA1; GATA1; GATA1; GATA2; GATA2; GATA2; NCOA1; TAL1; TAL1; TAL1; TAL1; ZNF823 (directAnnotation). GATA1; TAL1; TAL1; TAL1; TAL1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CSF3R	"Eflapegrastim"	DB15001	biotech
CSF3R	"FavId"	DB05249	small molecule
CSF3R	"Filgrastim"	DB00099	biotech
CSF3R	"Lenograstim"	DB13144	biotech
CSF3R	"Lipegfilgrastim"	DB13200	biotech
CSF3R	"Pegfilgrastim"	DB00019	biotech

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."