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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CS

Summary for CS

Gene information	Gene symbol	CS
	Ensembl ID	ENSG00000062485
	Entrez ID	1431
	Gene name	citrate synthase
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CS

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.645966	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.338945	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.895286	0.00e+00

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Expression of CS in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CS

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CS

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CS	hsa-miR-4722-5p	94.6853	NM_004077
CS	hsa-miR-3680-3p	93.8719	NM_004077
CS	hsa-miR-4261	93.4136	NM_004077
CS	hsa-miR-1264	93.2406	NM_004077
CS	hsa-miR-152-3p	91.8051	NM_004077
CS	hsa-miR-148a-3p	91.8051	NM_004077
CS	hsa-miR-148b-3p	91.8051	NM_004077
CS	hsa-miR-122-5p	91.6697	NM_004077
CS	hsa-miR-4775	91.5808	NM_004077
CS	hsa-miR-2053	91.3515	NM_004077
CS	hsa-miR-766-5p	91.0245	NM_004077
CS	hsa-miR-6825-5p	91.0084	NM_004077
CS	hsa-miR-147b-5p	90.4879	NM_004077
CS	hsa-miR-496	89.3193	NM_004077
CS	hsa-miR-7106-5p	89.299	NM_004077
CS	hsa-miR-590-3p	88.8353	NM_004077
CS	hsa-miR-1266-5p	85.622	NM_004077
CS	hsa-miR-4518	85.622	NM_004077
CS	hsa-miR-3161	84.3139	NM_004077
CS	hsa-miR-145-3p	83.3749	NM_004077
CS	hsa-miR-7114-5p	82.7222	NM_004077
CS	hsa-miR-4514	82.6065	NM_004077
CS	hsa-miR-4692	82.6065	NM_004077
CS	hsa-miR-494-3p	81.3184	NM_004077
CS	hsa-miR-552-5p	81.2712	NM_004077
CS	hsa-miR-4739	80.5643	NM_004077
CS	hsa-miR-1321	80.5643	NM_004077
CS	hsa-miR-4756-5p	80.5643	NM_004077

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Motifs and transcription factors (TFs) regulating CS

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CS	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
CS	metacluster_151.2	ZNF23 (directAnnotation).
CS	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CS	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CS	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CS	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
CS	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
CS	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CS	jaspar__MA1122.1	TFDP1 (directAnnotation).
CS	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CS	"alpha-Fluoro-carboxymethyldethia coenzyme A complex"	DB03182	small molecule
CS	"Citric acid"	DB04272	small molecule
CS	"Coenzyme A"	DB01992	small molecule
CS	"D-Malic acid"	DB03499	small molecule
CS	"Nitromethyldethia coenzyme A"	DB04230	small molecule
CS	"Oxaloacetate Ion"	DB02637	small molecule
CS	"Trifluoroacetonyl coenzyme A"	DB01969	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."