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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CRYBG1

Summary for CRYBG1

Gene information	Gene symbol	CRYBG1
	Ensembl ID	ENSG00000112297
	Entrez ID	202
	Gene name	crystallin beta-gamma domain containing 1
	Synonyms	AIM1\|ST4
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CRYBG1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.262547	5.95e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.255219	1.46e-42
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.312084	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	0.43269	1.98e-06

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Expression of CRYBG1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CRYBG1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CRYBG1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CRYBG1	hsa-miR-7157-5p	98.9394	NM_001624
CRYBG1	hsa-miR-4310	98.6514	NM_001624
CRYBG1	hsa-miR-646	96.6488	NM_001624
CRYBG1	hsa-miR-5004-5p	96.3683	NM_001624
CRYBG1	hsa-miR-3658	95.0777	NM_001624
CRYBG1	hsa-miR-103a-3p	94.3354	NM_001624
CRYBG1	hsa-miR-107	94.3354	NM_001624
CRYBG1	hsa-miR-5093	92.4253	NM_001624
CRYBG1	hsa-miR-5585-3p	90.1074	NM_001624
CRYBG1	hsa-miR-29a-3p	88.4691	NM_001624
CRYBG1	hsa-miR-29b-3p	88.4691	NM_001624
CRYBG1	hsa-miR-29c-3p	88.4691	NM_001624
CRYBG1	hsa-miR-4684-5p	84.8014	NM_001624
CRYBG1	hsa-miR-6792-5p	81.9112	NM_001624
CRYBG1	hsa-miR-4753-5p	80.9953	NM_001624
CRYBG1	hsa-miR-9-3p	80.0659	NM_001624
CRYBG1	hsa-miR-519a-2-5p	80.0502	NM_001624
CRYBG1	hsa-miR-520b-5p	80.0502	NM_001624

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Motifs and transcription factors (TFs) regulating CRYBG1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."