Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CRTAP

Summary for CRTAP

Gene information	Gene symbol	CRTAP
	Ensembl ID	ENSG00000170275
	Entrez ID	10491
	Gene name	cartilage associated protein
	Synonyms	CASP\|LEPREL3\|P3H5
	Gene type	protein_coding
	UniProtAcc	O75718

Top

Dataset with differentially expressed gene: CRTAP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.45267	1.14e-10
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.393535	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.344192	9.93e-14
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.396003	1.08e-25
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.413761	0.00e+00

Top

Expression of CRTAP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to CRTAP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating CRTAP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CRTAP	hsa-miR-1305	96.2884	NM_006371
CRTAP	hsa-miR-9902	95.3682	NM_006371
CRTAP	hsa-miR-6868-3p	94.2191	NM_006371
CRTAP	hsa-miR-1226-3p	91.0431	NM_006371
CRTAP	hsa-miR-4668-5p	88.9202	NM_006371
CRTAP	hsa-miR-373-5p	88.8359	NM_006371
CRTAP	hsa-miR-371b-5p	88.8359	NM_006371
CRTAP	hsa-miR-616-5p	88.8359	NM_006371
CRTAP	hsa-miR-587	88.5828	NM_006371
CRTAP	hsa-miR-6715a-3p	87.1063	NM_006371
CRTAP	hsa-miR-12131	85.5613	NM_006371
CRTAP	hsa-miR-1208	84.8651	NM_006371
CRTAP	hsa-miR-8066	84.6295	NM_006371
CRTAP	hsa-miR-7162-3p	84.2516	NM_006371
CRTAP	hsa-miR-3934-5p	82.7359	NM_006371
CRTAP	hsa-miR-6858-3p	82.3012	NM_006371
CRTAP	hsa-miR-200c-3p	81.3693	NM_006371
CRTAP	hsa-miR-429	81.3693	NM_006371
CRTAP	hsa-miR-200b-3p	81.3693	NM_006371
CRTAP	hsa-miR-548s	81.1694	NM_006371
CRTAP	hsa-miR-187-5p	81.0253	NM_006371
CRTAP	hsa-miR-6715b-3p	80.2894	NM_006371
CRTAP	hsa-miR-6730-3p	80.2255	NM_006371

Page: 1

Top

Motifs and transcription factors (TFs) regulating CRTAP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CRTAP	metacluster_151.2	ZNF23 (directAnnotation).
CRTAP	transfac_pro__M05628	ZNF735 (directAnnotation).
CRTAP	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CRTAP	jaspar__MA0079.5	SP1 (directAnnotation).
CRTAP	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
CRTAP	jaspar__MA1122.1	TFDP1 (directAnnotation).
CRTAP	transfac_pro__M06117	ZNF23 (directAnnotation).
CRTAP	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."