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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CROT

Summary for CROT

Gene information	Gene symbol	CROT
	Ensembl ID	ENSG00000005469
	Entrez ID	54677
	Gene name	carnitine O-octanoyltransferase
	Synonyms	COT
	Gene type	protein_coding
	UniProtAcc	Q9UKG9

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Dataset with differentially expressed gene: CROT

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.61169	1.57e-10

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Expression of CROT in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CROT

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CROT

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CROT	hsa-miR-302e	99.9554	NM_001143935
CROT	hsa-miR-302d-3p	99.8872	NM_001143935
CROT	hsa-miR-302c-3p	99.8872	NM_001143935
CROT	hsa-miR-302a-3p	99.8872	NM_001143935
CROT	hsa-miR-302b-3p	99.8872	NM_001143935
CROT	hsa-miR-373-3p	99.8371	NM_001143935
CROT	hsa-miR-520e-3p	99.8371	NM_001143935
CROT	hsa-miR-520b-3p	99.826	NM_001143935
CROT	hsa-miR-372-3p	99.826	NM_001143935
CROT	hsa-miR-520d-3p	99.826	NM_001143935
CROT	hsa-miR-520a-3p	99.826	NM_001143935
CROT	hsa-miR-520c-3p	99.826	NM_001143935
CROT	hsa-miR-520f-3p	99.501	NM_001143935
CROT	hsa-miR-33a-5p	99.0475	NM_001143935
CROT	hsa-miR-33b-5p	99.0475	NM_001143935
CROT	hsa-miR-1283	93.861	NM_001143935
CROT	hsa-miR-6884-3p	93.347	NM_001243745
CROT	hsa-miR-20a-5p	93.2548	NM_001143935
CROT	hsa-miR-106b-5p	93.2548	NM_001143935
CROT	hsa-miR-29a-5p	92.5042	NM_001243745
CROT	hsa-miR-1248	92.089	NM_001243745
CROT	hsa-miR-5004-3p	91.4739	NM_001243745
CROT	hsa-miR-190b-5p	91.3396	NM_021151
CROT	hsa-miR-190a-5p	91.3396	NM_021151
CROT	hsa-miR-526b-3p	90.7477	NM_001143935
CROT	hsa-miR-106a-5p	90.7477	NM_001143935
CROT	hsa-miR-93-5p	90.6147	NM_001143935
CROT	hsa-miR-17-5p	90.6147	NM_001143935
CROT	hsa-miR-20b-5p	90.6147	NM_001143935
CROT	hsa-miR-519d-3p	90.6147	NM_001143935
CROT	hsa-miR-573	90.0927	NM_001243745
CROT	hsa-miR-3616-5p	90.0927	NM_001243745
CROT	hsa-miR-6868-3p	89.9025	NM_001243745
CROT	hsa-miR-153-5p	89.8853	NM_001143935
CROT	hsa-miR-15b-3p	89.7442	NM_021151
CROT	hsa-miR-636	88.8375	NM_001143935
CROT	hsa-miR-3140-3p	88.5528	NM_001243745
CROT	hsa-miR-186-3p	88.5167	NM_001243745
CROT	hsa-miR-580-3p	88.2484	NM_021151
CROT	hsa-miR-605-3p	87.9776	NM_001143935
CROT	hsa-miR-217-5p	87.9348	NM_001143935
CROT	hsa-miR-3188	87.7995	NM_021151
CROT	hsa-miR-3160-3p	87.7767	NM_001243745
CROT	hsa-miR-4445-5p	87.4689	NM_001243745
CROT	hsa-miR-382-3p	86.1121	NM_001243745
CROT	hsa-miR-3120-3p	85.7649	NM_001243745
CROT	hsa-miR-944	84.4901	NM_001243745
CROT	hsa-miR-6074	84.4341	NM_021151
CROT	hsa-miR-3168	84.1549	NM_001143935
CROT	hsa-miR-4666a-3p	84.1546	NM_001243745

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Motifs and transcription factors (TFs) regulating CROT

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CROT	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
CROT	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
CROT	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
CROT	transfac_pro__M04617	ZBTB7A (directAnnotation).
CROT	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CROT	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
CROT	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CROT	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CROT	transfac_pro__M07387	ZBTB7A (directAnnotation).
CROT	transfac_pro__M07436	WT1 (directAnnotation).
CROT	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CROT	transfac_pro__M00716	ZBTB14 (directAnnotation).
CROT	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CROT	hdpi__HIP2	UBE2K (directAnnotation).
CROT	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CROT	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CROT	transfac_pro__M04893	TAF1 (directAnnotation).
CROT	transfac_pro__M03876	ZBTB33 (directAnnotation).
CROT	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CROT	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CROT	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
CROT	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CROT	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CROT	"(3-Carboxy-2-(R)-Hydroxy-Propyl)-Trimethyl-Ammonium"	DB02648	small molecule
CROT	"3-Carboxy-N,N,N-Trimethyl-2-(Octanoyloxy)Propan-1-Aminium"	DB03832	small molecule
CROT	"Levocarnitine"	DB00583	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."