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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CREBL2

Summary for CREBL2

Gene information	Gene symbol	CREBL2
	Ensembl ID	ENSG00000111269
	Entrez ID	1389
	Gene name	cAMP responsive element binding protein like 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	O60519

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Dataset with differentially expressed gene: CREBL2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.363708	0.00e+00

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Expression of CREBL2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CREBL2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CREBL2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CREBL2	hsa-miR-340-5p	96.9983	NM_001310
CREBL2	hsa-miR-32-3p	96.7774	NM_001310
CREBL2	hsa-miR-3121-3p	96.5809	NM_001310
CREBL2	hsa-miR-548c-3p	96.4216	NM_001310
CREBL2	hsa-miR-18a-5p	96.1819	NM_001310
CREBL2	hsa-miR-18b-5p	96.1819	NM_001310
CREBL2	hsa-miR-3163	95.6739	NM_001310
CREBL2	hsa-miR-4735-3p	95.5621	NM_001310
CREBL2	hsa-miR-4735-5p	95.4092	NM_001310
CREBL2	hsa-miR-567	93.5767	NM_001310
CREBL2	hsa-miR-577	93.5549	NM_001310
CREBL2	hsa-miR-505-5p	93.4329	NM_001310
CREBL2	hsa-miR-646	93.2597	NM_001310
CREBL2	hsa-miR-19a-5p	92.6381	NM_001310
CREBL2	hsa-miR-19b-1-5p	92.6381	NM_001310
CREBL2	hsa-miR-19b-2-5p	92.6381	NM_001310
CREBL2	hsa-miR-1246	92.5062	NM_001310
CREBL2	hsa-miR-4802-3p	91.5304	NM_001310
CREBL2	hsa-miR-3978	91.2548	NM_001310
CREBL2	hsa-miR-653-3p	90.8002	NM_001310
CREBL2	hsa-miR-377-3p	90.6006	NM_001310
CREBL2	hsa-miR-450a-1-3p	90.1205	NM_001310
CREBL2	hsa-miR-6858-3p	89.9713	NM_001310
CREBL2	hsa-miR-1-3p	89.8833	NM_001310
CREBL2	hsa-miR-206	89.8833	NM_001310
CREBL2	hsa-miR-2053	89.5384	NM_001310
CREBL2	hsa-miR-4650-3p	89.4928	NM_001310
CREBL2	hsa-miR-519e-5p	88.4346	NM_001310
CREBL2	hsa-miR-515-5p	88.4346	NM_001310
CREBL2	hsa-miR-589-3p	87.9739	NM_001310
CREBL2	hsa-miR-503-5p	87.7023	NM_001310
CREBL2	hsa-miR-613	87.6327	NM_001310
CREBL2	hsa-miR-4284	87.5634	NM_001310
CREBL2	hsa-miR-761	87.4925	NM_001310
CREBL2	hsa-miR-214-3p	87.4925	NM_001310
CREBL2	hsa-miR-4668-5p	87.33	NM_001310
CREBL2	hsa-miR-3619-5p	87.2555	NM_001310
CREBL2	hsa-miR-4275	86.807	NM_001310
CREBL2	hsa-miR-548aw	86.0575	NM_001310
CREBL2	hsa-miR-221-3p	85.7909	NM_001310
CREBL2	hsa-miR-6739-5p	84.817	NM_001310
CREBL2	hsa-miR-6733-5p	84.817	NM_001310
CREBL2	hsa-miR-5003-3p	83.8424	NM_001310
CREBL2	hsa-miR-5190	83.5462	NM_001310
CREBL2	hsa-miR-3153	83.0723	NM_001310
CREBL2	hsa-miR-196a-5p	82.8894	NM_001310
CREBL2	hsa-miR-196b-5p	82.8894	NM_001310
CREBL2	hsa-miR-498-5p	82.6763	NM_001310
CREBL2	hsa-miR-4662a-5p	82.152	NM_001310
CREBL2	hsa-miR-578	81.7343	NM_001310

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Motifs and transcription factors (TFs) regulating CREBL2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CREBL2	hdpi__ETV4	ETV4 (directAnnotation).
CREBL2	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."