Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: CREB3L1

Summary for CREB3L1

Gene information	Gene symbol	CREB3L1
	Ensembl ID	ENSG00000157613
	Entrez ID	90993
	Gene name	cAMP responsive element binding protein 3 like 1
	Synonyms	OASIS
	Gene type	protein_coding
	UniProtAcc	Q96BA8

Top

Dataset with differentially expressed gene: CREB3L1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-4.07168	3.33e-12
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.401169	2.19e-20
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.754164	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.454671	0.00e+00

Top

Expression of CREB3L1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to CREB3L1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating CREB3L1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CREB3L1	hsa-miR-4663	93.1216	NM_052854
CREB3L1	hsa-miR-338-5p	93.0472	NM_052854
CREB3L1	hsa-miR-4481	92.6293	NM_052854
CREB3L1	hsa-miR-3147	92.5415	NM_052854
CREB3L1	hsa-miR-6783-3p	92.463	NM_052854
CREB3L1	hsa-miR-1238-5p	92.2039	NM_052854
CREB3L1	hsa-miR-4758-5p	92.2039	NM_052854
CREB3L1	hsa-miR-4745-5p	92.1862	NM_052854
CREB3L1	hsa-miR-6130	91.2722	NM_052854
CREB3L1	hsa-miR-6742-3p	91.1921	NM_052854
CREB3L1	hsa-miR-6129	91.1575	NM_052854
CREB3L1	hsa-miR-4510	91.1575	NM_052854
CREB3L1	hsa-miR-6133	91.1575	NM_052854
CREB3L1	hsa-miR-6127	91.1575	NM_052854
CREB3L1	hsa-miR-1343-3p	91.1136	NM_052854
CREB3L1	hsa-miR-4666a-3p	91.0622	NM_052854
CREB3L1	hsa-miR-6885-3p	89.2305	NM_052854
CREB3L1	hsa-miR-7160-5p	88.9534	NM_052854
CREB3L1	hsa-miR-182-5p	86.9472	NM_052854
CREB3L1	hsa-miR-8077	86.0495	NM_052854
CREB3L1	hsa-miR-6075	85.2957	NM_052854
CREB3L1	hsa-miR-5196-5p	84.576	NM_052854
CREB3L1	hsa-miR-4747-5p	84.576	NM_052854
CREB3L1	hsa-miR-92a-2-5p	84.484	NM_052854
CREB3L1	hsa-miR-4652-3p	83.4002	NM_052854
CREB3L1	hsa-miR-6770-5p	82.247	NM_052854
CREB3L1	hsa-miR-3160-3p	82.2405	NM_052854
CREB3L1	hsa-miR-19b-1-5p	82.1211	NM_052854
CREB3L1	hsa-miR-19a-5p	82.1211	NM_052854
CREB3L1	hsa-miR-19b-2-5p	82.1211	NM_052854
CREB3L1	hsa-miR-7110-5p	81.3234	NM_052854
CREB3L1	hsa-miR-6842-5p	81.3234	NM_052854
CREB3L1	hsa-miR-3160-5p	81.1166	NM_052854
CREB3L1	hsa-miR-203b-5p	80.0731	NM_052854
CREB3L1	hsa-miR-6718-5p	80.0731	NM_052854

Page: 1

Top

Motifs and transcription factors (TFs) regulating CREB3L1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CREB3L1	transfac_pro__M06035	ZNF749 (directAnnotation).
CREB3L1	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
CREB3L1	metacluster_98.1	ZNF524 (directAnnotation).
CREB3L1	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
CREB3L1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
CREB3L1	metacluster_198.3	ZFP64 (directAnnotation).
CREB3L1	transfac_pro__M06609	ZKSCAN4 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
CREB3L1	metacluster_173.2	up	Malignant cells	GSE207422_Tor	post

Page: 1

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."