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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CREB1

Summary for CREB1

Gene information	Gene symbol	CREB1
	Ensembl ID	ENSG00000118260
	Entrez ID	1385
	Gene name	cAMP responsive element binding protein 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P16220

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Dataset with differentially expressed gene: CREB1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.277045	0.00e+00

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Expression of CREB1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CREB1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
CREB1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating CREB1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CREB1	hsa-miR-5011-5p	99.9999	NM_004379
CREB1	hsa-miR-190a-3p	99.996	NM_004379
CREB1	hsa-miR-12136	99.9797	NM_004379
CREB1	hsa-miR-3682-5p	99.9275	NM_004379
CREB1	hsa-miR-6835-3p	99.9261	NM_004379
CREB1	hsa-miR-5004-5p	99.6825	NM_134442
CREB1	hsa-miR-153-5p	99.4906	NM_134442
CREB1	hsa-miR-5680	99.1969	NM_134442
CREB1	hsa-miR-3662	99.1111	NM_004379
CREB1	hsa-miR-30e-3p	98.8351	NM_004379
CREB1	hsa-miR-30d-3p	98.8351	NM_004379
CREB1	hsa-miR-30a-3p	98.8351	NM_004379
CREB1	hsa-miR-4422	98.7904	NM_004379
CREB1	hsa-miR-548c-3p	98.5954	NM_004379
CREB1	hsa-miR-33a-3p	97.9818	NM_134442
CREB1	hsa-miR-4719	97.9576	NM_004379
CREB1	hsa-miR-1250-3p	97.6706	NM_134442
CREB1	hsa-miR-570-3p	97.6566	NM_004379
CREB1	hsa-miR-513c-3p	97.6337	NM_134442
CREB1	hsa-miR-513a-3p	97.6337	NM_134442
CREB1	hsa-miR-577	97.487	NM_134442
CREB1	hsa-miR-548s	97.4833	NM_004379
CREB1	hsa-miR-1297	97.4663	NM_004379
CREB1	hsa-miR-3606-3p	97.3058	NM_134442
CREB1	hsa-miR-526b-5p	97.2318	NM_004379
CREB1	hsa-miR-218-5p	97.1462	NM_004379
CREB1	hsa-miR-4310	97.124	NM_004379
CREB1	hsa-miR-4789-3p	96.9489	NM_004379
CREB1	hsa-miR-3613-3p	96.791	NM_004379
CREB1	hsa-miR-12123	96.6916	NM_001320793
CREB1	hsa-miR-7157-5p	96.6477	NM_004379
CREB1	hsa-miR-1277-5p	96.1552	NM_004379
CREB1	hsa-miR-4262	96.1196	NM_004379
CREB1	hsa-miR-3163	96.1006	NM_004379
CREB1	hsa-miR-590-3p	96.041	NM_134442
CREB1	hsa-miR-633	95.2529	NM_134442
CREB1	hsa-miR-4698	95.2126	NM_004379
CREB1	hsa-miR-26b-5p	95.1828	NM_004379
CREB1	hsa-miR-26a-5p	95.1828	NM_004379
CREB1	hsa-miR-543	94.9877	NM_134442
CREB1	hsa-miR-5582-3p	94.6329	NM_134442
CREB1	hsa-miR-181b-5p	94.4066	NM_004379
CREB1	hsa-miR-181d-5p	94.4066	NM_004379
CREB1	hsa-miR-181a-5p	94.4066	NM_004379
CREB1	hsa-miR-181c-5p	94.4066	NM_004379
CREB1	hsa-miR-340-5p	94.3943	NM_004379
CREB1	hsa-miR-4282	94.2115	NM_004379
CREB1	hsa-miR-3184-3p	94.1536	NM_004379
CREB1	hsa-miR-548aa	93.9638	NM_004379
CREB1	hsa-miR-548t-3p	93.9638	NM_004379

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Motifs and transcription factors (TFs) regulating CREB1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CREB1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CREB1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CREB1	transfac_pro__M07397	ZNF148 (directAnnotation).
CREB1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
CREB1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
CREB1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
CREB1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CREB1	metacluster_7.13	ZFX (directAnnotation).
CREB1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
CREB1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
CREB1	transfac_pro__M01175	ZBTB7B (directAnnotation).
CREB1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CREB1	tfdimers__MD00151	CHURC1 (directAnnotation).
CREB1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CREB1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CREB1	transfac_pro__M01303	SP1 (directAnnotation).
CREB1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CREB1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CREB1	transfac_pro__M02090	E2F4 (directAnnotation).
CREB1	transfac_pro__M01714	KLF15 (directAnnotation).
CREB1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CREB1	jaspar__MA1122.1	TFDP1 (directAnnotation).
CREB1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
CREB1	transfac_pro__M02089	E2F3 (directAnnotation).
CREB1	metacluster_3.14	WT1; WT1 (directAnnotation).
CREB1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
CREB1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
CREB1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
CREB1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
CREB1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CREB1	cisbp__M07938	E2F1 (directAnnotation).
CREB1	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
CREB1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
CREB1	transfac_pro__M07436	WT1 (directAnnotation).
CREB1	transfac_pro__M02281	SP1 (directAnnotation).
CREB1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
CREB1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CREB1	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
CREB1	transfac_pro__M02898	SMAD3 (directAnnotation).
CREB1	transfac_public__M00491	PATZ1 (directAnnotation).
CREB1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CREB1	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CREB1	"Adenosine phosphate"	DB00131	small molecule
CREB1	"Naloxone"	DB01183	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."