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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CR1

Summary for CR1

Gene information	Gene symbol	CR1
	Ensembl ID	ENSG00000203710
	Entrez ID	1378
	Gene name	complement C3b/C4b receptor 1 (Knops blood group)
	Synonyms	CD35\|KN
	Gene type	protein_coding
	UniProtAcc	P17927

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Dataset with differentially expressed gene: CR1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.250416	7.22e-03

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Expression of CR1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CR1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CR1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CR1	hsa-miR-4451	93.9939	NM_000651
CR1	hsa-miR-3163	90.9008	NM_000573
CR1	hsa-miR-1245b-3p	90.8573	NM_000651
CR1	hsa-miR-371b-5p	90.0807	NM_000651
CR1	hsa-miR-373-5p	90.0807	NM_000651
CR1	hsa-miR-616-5p	90.0807	NM_000651
CR1	hsa-miR-3613-3p	88.7387	NM_000651
CR1	hsa-miR-628-3p	88.0659	NM_000651
CR1	hsa-miR-578	87.5363	NM_000651
CR1	hsa-miR-6867-3p	87.1198	NM_000651
CR1	hsa-miR-519d-5p	87.1163	NM_000651
CR1	hsa-miR-1299	86.5557	NM_000651
CR1	hsa-miR-520f-5p	86.4726	NM_000651
CR1	hsa-miR-1468-3p	86.432	NM_000651
CR1	hsa-miR-875-3p	84.6239	NM_000651
CR1	hsa-miR-548aw	84.2939	NM_000651
CR1	hsa-miR-2117	83.869	NM_000651
CR1	hsa-miR-3133	83.7467	NM_000651
CR1	hsa-miR-1260b	82.9663	NM_000651
CR1	hsa-miR-1260a	82.9663	NM_000651
CR1	hsa-miR-3140-3p	82.9335	NM_000651
CR1	hsa-miR-3148	82.7542	NM_000651
CR1	hsa-miR-6511a-5p	82.5475	NM_000651
CR1	hsa-miR-4528	82.4296	NM_000651
CR1	hsa-miR-603	82.3109	NM_000651

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Motifs and transcription factors (TFs) regulating CR1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CR1	metacluster_80.6	ZIC4 (directAnnotation).
CR1	metacluster_72.9	SALL2 (directAnnotation). SALL2 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."