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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CPT1A

Summary for CPT1A

Gene information	Gene symbol	CPT1A
	Ensembl ID	ENSG00000110090
	Entrez ID	1374
	Gene name	carnitine palmitoyltransferase 1A
	Synonyms	CPT1\|CPT1-L\|L-CPT1
	Gene type	protein_coding
	UniProtAcc	P50416

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Dataset with differentially expressed gene: CPT1A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.478351	1.18e-39
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.62179	0.00e+00

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Expression of CPT1A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CPT1A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CPT1A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CPT1A	hsa-miR-4307	98.0027	NM_001876
CPT1A	hsa-miR-664b-3p	96.4024	NM_001876
CPT1A	hsa-miR-579-3p	96.4024	NM_001876
CPT1A	hsa-miR-506-3p	96.2375	NM_001876
CPT1A	hsa-miR-124-3p	95.6162	NM_001876
CPT1A	hsa-miR-5087	95.2426	NM_001876
CPT1A	hsa-miR-302c-5p	94.4349	NM_001031847
CPT1A	hsa-miR-6718-5p	94.0783	NM_001876
CPT1A	hsa-miR-203b-5p	94.0783	NM_001876
CPT1A	hsa-miR-604	93.1165	NM_001876
CPT1A	hsa-miR-4533	93.0684	NM_001876
CPT1A	hsa-miR-1252-5p	92.7841	NM_001876
CPT1A	hsa-miR-510-3p	91.7401	NM_001876
CPT1A	hsa-miR-3613-3p	90.7549	NM_001876
CPT1A	hsa-miR-33b-5p	90.6433	NM_001876
CPT1A	hsa-miR-33a-5p	90.6433	NM_001876
CPT1A	hsa-miR-33a-3p	90.1386	NM_001876
CPT1A	hsa-miR-3977	89.0621	NM_001876
CPT1A	hsa-miR-324-5p	87.4991	NM_001876
CPT1A	hsa-miR-5696	86.7912	NM_001876
CPT1A	hsa-miR-335-3p	85.7375	NM_001876
CPT1A	hsa-miR-9983-3p	85.5487	NM_001876
CPT1A	hsa-miR-1299	85.3808	NM_001876
CPT1A	hsa-miR-409-3p	84.8653	NM_001876
CPT1A	hsa-miR-4263	84.8036	NM_001876
CPT1A	hsa-miR-5685	84.4311	NM_001876
CPT1A	hsa-miR-4690-3p	84.4311	NM_001876
CPT1A	hsa-miR-651-3p	84.0687	NM_001876
CPT1A	hsa-miR-129-5p	83.9118	NM_001876
CPT1A	hsa-miR-3152-3p	83.3011	NM_001876
CPT1A	hsa-miR-760	82.7942	NM_001876
CPT1A	hsa-miR-4324	81.7745	NM_001876
CPT1A	hsa-miR-3136-3p	80.5997	NM_001876
CPT1A	hsa-miR-7155-3p	80.5997	NM_001876

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Motifs and transcription factors (TFs) regulating CPT1A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CPT1A	metacluster_135.11	NR2C2 (directAnnotation).
CPT1A	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
CPT1A	transfac_pro__M01199	TRIM28 (directAnnotation).
CPT1A	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CPT1A	transfac_pro__M03806	ZBTB7C (directAnnotation).
CPT1A	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CPT1A	"Glyburide"	DB01016	small molecule
CPT1A	"Levocarnitine"	DB00583	small molecule
CPT1A	"Perhexiline"	DB01074	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."