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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CPNE5

Summary for CPNE5

Gene information	Gene symbol	CPNE5
	Ensembl ID	ENSG00000124772
	Entrez ID	57699
	Gene name	copine 5
	Synonyms	COPN5\|CPN5\|KIAA1599
	Gene type	protein_coding
	UniProtAcc	Q9HCH3

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Dataset with differentially expressed gene: CPNE5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.358898	0.00e+00

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Expression of CPNE5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CPNE5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CPNE5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CPNE5	hsa-miR-5008-5p	97.2943	NM_001314018
CPNE5	hsa-miR-548b-3p	91.8955	NM_001314018
CPNE5	hsa-miR-6791-5p	91.1721	NM_001314018
CPNE5	hsa-miR-4505	91.0507	NM_001314018
CPNE5	hsa-miR-5787	90.7676	NM_001314018
CPNE5	hsa-miR-6797-3p	90.1902	NM_001314018
CPNE5	hsa-miR-3133	88.7981	NM_001314018
CPNE5	hsa-miR-6737-5p	87.6462	NM_001314018
CPNE5	hsa-miR-6819-5p	87.6462	NM_001314018
CPNE5	hsa-miR-6780b-5p	87.3843	NM_001314018
CPNE5	hsa-miR-6795-5p	86.7797	NM_001314018
CPNE5	hsa-miR-6887-5p	86.7797	NM_001314018
CPNE5	hsa-miR-4292	86.7565	NM_001314018
CPNE5	hsa-miR-328-5p	86.4622	NM_001314018
CPNE5	hsa-miR-4725-3p	85.0305	NM_001314018
CPNE5	hsa-miR-6812-5p	84.8721	NM_001314018
CPNE5	hsa-miR-4492	84.6188	NM_001314018
CPNE5	hsa-miR-506-3p	84.2104	NM_001314018
CPNE5	hsa-miR-124-3p	84.2104	NM_001314018
CPNE5	hsa-miR-6076	83.9535	NM_001314018
CPNE5	hsa-miR-188-3p	83.1677	NM_001314018
CPNE5	hsa-miR-7109-5p	82.6346	NM_001314018
CPNE5	hsa-miR-4271	81.5803	NM_001314018
CPNE5	hsa-miR-6089	80.189	NM_001314018

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Motifs and transcription factors (TFs) regulating CPNE5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CPNE5	transfac_pro__M07397	ZNF148 (directAnnotation).
CPNE5	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CPNE5	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
CPNE5	transfac_pro__M07436	WT1 (directAnnotation).
CPNE5	metacluster_3.14	WT1; WT1 (directAnnotation).
CPNE5	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
CPNE5	metacluster_170.1	ZNF460; ZNF460; ZNF468; ZNF468 (directAnnotation).
CPNE5	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CPNE5	transfac_pro__M01303	SP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."