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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: COX11

Summary for COX11

Gene information	Gene symbol	COX11
	Ensembl ID	ENSG00000166260
	Entrez ID	1353
	Gene name	cytochrome c oxidase copper chaperone COX11
	Synonyms	COX11P
	Gene type	protein_coding
	UniProtAcc	Q9Y6N1

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Dataset with differentially expressed gene: COX11

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.566304	6.91e-04
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.849844	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.648448	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.294515	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.383167	5.80e-24
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.375441	8.18e-14
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.445025	5.21e-26
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.362093	2.09e-13
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.305375	3.37e-26

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Expression of COX11 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to COX11

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating COX11

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
COX11	hsa-miR-1252-5p	97.7621	NM_004375
COX11	hsa-miR-4753-3p	97.0391	NM_004375
COX11	hsa-miR-1253	94.529	NM_004375
COX11	hsa-miR-4427	92.9449	NM_004375
COX11	hsa-miR-506-5p	92.4821	NM_004375
COX11	hsa-miR-4680-3p	91.815	NM_004375
COX11	hsa-miR-580-3p	91.5631	NM_004375
COX11	hsa-miR-4679	91.5563	NM_001321518
COX11	hsa-miR-5187-3p	91.1163	NM_004375
COX11	hsa-miR-4699-5p	90.8681	NM_004375
COX11	hsa-miR-1909-5p	89.7015	NM_004375
COX11	hsa-miR-3973	89.197	NM_004375
COX11	hsa-miR-4325	87.5656	NM_004375
COX11	hsa-miR-944	87.3096	NM_004375
COX11	hsa-miR-302c-5p	87.2475	NM_004375
COX11	hsa-miR-942-5p	85.8188	NM_004375
COX11	hsa-miR-6894-3p	85.6981	NM_004375
COX11	hsa-miR-3922-3p	85.0269	NM_004375
COX11	hsa-miR-3121-3p	84.2407	NM_004375
COX11	hsa-miR-4714-5p	83.6736	NM_004375
COX11	hsa-miR-5681b	83.2335	NM_004375
COX11	hsa-miR-2117	82.522	NM_004375
COX11	hsa-miR-543	81.2279	NM_004375
COX11	hsa-miR-4291	80.3397	NM_004375
COX11	hsa-miR-6770-5p	80.2196	NM_004375

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Motifs and transcription factors (TFs) regulating COX11

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
COX11	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
COX11	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
COX11	transfac_pro__M00652	NRF1 (directAnnotation).
COX11	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
COX11	transfac_pro__M04866	HDAC2 (directAnnotation).
COX11	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
COX11	hdpi__FLI1	FLI1 (directAnnotation).
COX11	transfac_pro__M05750	ZNF77 (directAnnotation).
COX11	transfac_pro__M01660	GABPA (directAnnotation).
COX11	taipale_cyt_meth__ZBTB2_NTTTCCGGTAMN_eDBD_meth_repr	ZBTB2 (directAnnotation).
COX11	metacluster_22.29	NFE2 (directAnnotation).
COX11	c2h2_zfs__M0401	ZNF410 (inferredBy_Orthology).
COX11	transfac_pro__M07392	PITX3 (directAnnotation).
COX11	hdpi__TP73	TP73 (directAnnotation).
COX11	cisbp__M08198	ELF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."