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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: COPS7B

Summary for COPS7B

Gene information	Gene symbol	COPS7B
	Ensembl ID	ENSG00000144524
	Entrez ID	64708
	Gene name	COP9 signalosome subunit 7B
	Synonyms	CSN7B
	Gene type	protein_coding
	UniProtAcc	Q9H9Q2

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Dataset with differentially expressed gene: COPS7B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.265502	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.289595	7.32e-42

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Expression of COPS7B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to COPS7B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating COPS7B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
COPS7B	hsa-miR-8485	99.7276	NM_001282951
COPS7B	hsa-miR-486-5p	96.8	NM_001308381
COPS7B	hsa-miR-649	95.9614	NM_001308381
COPS7B	hsa-miR-4492	93.0273	NM_001308381
COPS7B	hsa-miR-7-2-3p	92.6552	NM_001308381
COPS7B	hsa-miR-7-1-3p	92.6552	NM_001308381
COPS7B	hsa-miR-5001-5p	91.7466	NM_001308381
COPS7B	hsa-miR-4498	91.7466	NM_001308381
COPS7B	hsa-miR-4707-5p	90.4016	NM_001308381
COPS7B	hsa-miR-7106-5p	90.2332	NM_001308381
COPS7B	hsa-miR-665	89.9798	NM_001308381
COPS7B	hsa-miR-203a-3p	89.5185	NM_001308381
COPS7B	hsa-miR-185-3p	89.2261	NM_001308381
COPS7B	hsa-miR-653-5p	88.9274	NM_001282951
COPS7B	hsa-miR-5688	88.5667	NM_001308381
COPS7B	hsa-miR-762	88.2713	NM_001308381
COPS7B	hsa-miR-4478	87.3468	NM_001308381
COPS7B	hsa-miR-6785-5p	87.0712	NM_001282951
COPS7B	hsa-miR-4728-5p	87.0712	NM_001282951
COPS7B	hsa-miR-16-5p	86.374	NM_001308381
COPS7B	hsa-miR-195-5p	86.374	NM_001308381
COPS7B	hsa-miR-424-5p	86.374	NM_001308381
COPS7B	hsa-miR-497-5p	86.374	NM_001308381
COPS7B	hsa-miR-15b-5p	86.374	NM_001308381
COPS7B	hsa-miR-15a-5p	86.374	NM_001308381
COPS7B	hsa-miR-6838-5p	86.374	NM_001308381
COPS7B	hsa-miR-5006-5p	86.3244	NM_001308381
COPS7B	hsa-miR-940	86.1123	NM_001308381
COPS7B	hsa-miR-6808-5p	86.1123	NM_001308381
COPS7B	hsa-miR-6893-5p	86.1123	NM_001308381
COPS7B	hsa-miR-3945	84.2196	NM_001282951
COPS7B	hsa-miR-495-3p	84.1452	NM_001308381
COPS7B	hsa-miR-3613-3p	83.2802	NM_001282951
COPS7B	hsa-miR-5000-5p	82.912	NM_001308381
COPS7B	hsa-miR-6883-5p	82.3415	NM_001282951
COPS7B	hsa-miR-149-3p	82.3415	NM_001282951
COPS7B	hsa-miR-4261	82.2636	NM_001282951
COPS7B	hsa-miR-423-5p	82.2268	NM_001282951
COPS7B	hsa-miR-3184-5p	82.2268	NM_001282951
COPS7B	hsa-miR-6825-5p	81.9925	NM_001282951
COPS7B	hsa-miR-4779	80.8663	NM_001308381
COPS7B	hsa-miR-1304-3p	80.7746	NM_001308381
COPS7B	hsa-miR-6758-5p	80.4796	NM_001282951
COPS7B	hsa-miR-4738-3p	80.2841	NM_001282951

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Motifs and transcription factors (TFs) regulating COPS7B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
COPS7B	metacluster_151.2	ZNF23 (directAnnotation).
COPS7B	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
COPS7B	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
COPS7B	jaspar__MA0079.5	SP1 (directAnnotation).
COPS7B	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
COPS7B	transfac_pro__M07397	ZNF148 (directAnnotation).
COPS7B	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
COPS7B	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
COPS7B	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
COPS7B	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
COPS7B	transfac_pro__M01175	ZBTB7B (directAnnotation).
COPS7B	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
COPS7B	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
COPS7B	transfac_pro__M01303	SP1 (directAnnotation).
COPS7B	metacluster_3.14	WT1; WT1 (directAnnotation).
COPS7B	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
COPS7B	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
COPS7B	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
COPS7B	transfac_pro__M07436	WT1 (directAnnotation).
COPS7B	transfac_pro__M02281	SP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."