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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: COL5A2

Summary for COL5A2

Gene information	Gene symbol	COL5A2
	Ensembl ID	ENSG00000204262
	Entrez ID	1290
	Gene name	collagen type V alpha 2 chain
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P05997

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Dataset with differentially expressed gene: COL5A2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-2.2729	8.35e-07
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.302833	6.43e-18
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.293634	1.34e-12

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Expression of COL5A2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to COL5A2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating COL5A2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
COL5A2	hsa-miR-3658	99.2988	NM_000393
COL5A2	hsa-miR-323a-5p	98.5868	NM_000393
COL5A2	hsa-miR-5682	97.8546	NM_000393
COL5A2	hsa-miR-29a-3p	96.8371	NM_000393
COL5A2	hsa-miR-29c-3p	96.8371	NM_000393
COL5A2	hsa-miR-29b-3p	96.8371	NM_000393
COL5A2	hsa-miR-5007-5p	95.4533	NM_000393
COL5A2	hsa-miR-1251-3p	93.9587	NM_000393
COL5A2	hsa-miR-6820-3p	93.0599	NM_000393
COL5A2	hsa-miR-3164	93.0599	NM_000393
COL5A2	hsa-miR-224-3p	92.5063	NM_000393
COL5A2	hsa-miR-3907	91.7667	NM_000393
COL5A2	hsa-miR-3678-3p	91.4385	NM_000393
COL5A2	hsa-miR-570-3p	91.1093	NM_000393
COL5A2	hsa-miR-522-3p	90.5852	NM_000393
COL5A2	hsa-miR-888-5p	89.8626	NM_000393
COL5A2	hsa-miR-4307	89.5556	NM_000393
COL5A2	hsa-miR-4477b	89.4589	NM_000393
COL5A2	hsa-miR-6871-3p	89.389	NM_000393
COL5A2	hsa-miR-6824-5p	88.9636	NM_000393
COL5A2	hsa-miR-4482-3p	88.9611	NM_000393
COL5A2	hsa-miR-6783-5p	88.9143	NM_000393
COL5A2	hsa-miR-7856-5p	88.3409	NM_000393
COL5A2	hsa-miR-6759-5p	87.712	NM_000393
COL5A2	hsa-miR-5582-3p	87.5457	NM_000393
COL5A2	hsa-miR-4756-3p	87.2312	NM_000393
COL5A2	hsa-miR-6505-5p	85.6367	NM_000393
COL5A2	hsa-miR-148a-5p	84.8921	NM_000393
COL5A2	hsa-miR-4500	84.2373	NM_000393
COL5A2	hsa-miR-4755-3p	84.1601	NM_000393
COL5A2	hsa-miR-4470	82.8614	NM_000393
COL5A2	hsa-miR-5696	82.6572	NM_000393
COL5A2	hsa-miR-499a-5p	82.2562	NM_000393
COL5A2	hsa-miR-1468-3p	82.169	NM_000393
COL5A2	hsa-miR-153-5p	81.8804	NM_000393
COL5A2	hsa-miR-5680	81.478	NM_000393
COL5A2	hsa-miR-335-5p	81.15	NM_000393
COL5A2	hsa-miR-3973	80.9893	NM_000393
COL5A2	hsa-miR-5093	80.9387	NM_000393
COL5A2	hsa-miR-98-5p	80.445	NM_000393
COL5A2	hsa-let-7e-5p	80.445	NM_000393
COL5A2	hsa-let-7g-5p	80.445	NM_000393
COL5A2	hsa-let-7i-5p	80.445	NM_000393
COL5A2	hsa-let-7c-5p	80.445	NM_000393
COL5A2	hsa-let-7a-5p	80.445	NM_000393
COL5A2	hsa-let-7b-5p	80.445	NM_000393
COL5A2	hsa-let-7f-5p	80.445	NM_000393
COL5A2	hsa-miR-6504-3p	80.2645	NM_000393
COL5A2	hsa-miR-10399-5p	80.2645	NM_000393

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Motifs and transcription factors (TFs) regulating COL5A2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
COL5A2	transfac_pro__M05791	ZNF517 (directAnnotation).
COL5A2	metacluster_153.4	SOX12; SOX14; SRY (directAnnotation). SOX5 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."