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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: COL5A1

Summary for COL5A1

Gene information	Gene symbol	COL5A1
	Ensembl ID	ENSG00000130635
	Entrez ID	1289
	Gene name	collagen type V alpha 1 chain
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P20908

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Dataset with differentially expressed gene: COL5A1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.298744	1.32e-12
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.54725	5.08e-41
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.430785	4.03e-19

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Expression of COL5A1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to COL5A1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating COL5A1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
COL5A1	hsa-miR-29b-3p	99.9203	NM_000093
COL5A1	hsa-miR-29c-3p	99.9203	NM_000093
COL5A1	hsa-miR-29a-3p	99.9203	NM_000093
COL5A1	hsa-miR-5682	98.8733	NM_000093
COL5A1	hsa-miR-498-3p	98.2617	NM_000093
COL5A1	hsa-miR-582-5p	98.0958	NM_000093
COL5A1	hsa-miR-544a	96.4704	NM_000093
COL5A1	hsa-miR-137-3p	94.0347	NM_000093
COL5A1	hsa-miR-3119	93.8736	NM_000093
COL5A1	hsa-miR-493-3p	92.8549	NM_000093
COL5A1	hsa-miR-190a-3p	91.8647	NM_000093
COL5A1	hsa-miR-4446-5p	90.461	NM_001278074
COL5A1	hsa-miR-4772-3p	90.2338	NM_000093
COL5A1	hsa-miR-3148	90.068	NM_001278074
COL5A1	hsa-miR-4699-3p	89.6626	NM_000093
COL5A1	hsa-miR-3678-5p	89.3372	NM_000093
COL5A1	hsa-miR-5011-5p	89.0667	NM_000093
COL5A1	hsa-miR-2276-3p	89.0431	NM_000093
COL5A1	hsa-miR-4318	88.4836	NM_001278074
COL5A1	hsa-miR-4757-5p	87.5243	NM_001278074
COL5A1	hsa-miR-6744-3p	87.5243	NM_001278074
COL5A1	hsa-miR-32-5p	87.2633	NM_000093
COL5A1	hsa-miR-92b-3p	87.2633	NM_000093
COL5A1	hsa-miR-92a-3p	87.2633	NM_000093
COL5A1	hsa-miR-5187-5p	86.8108	NM_001278074
COL5A1	hsa-miR-6878-3p	86.2528	NM_001278074
COL5A1	hsa-miR-6760-3p	86.0619	NM_000093
COL5A1	hsa-miR-6871-3p	85.799	NM_000093
COL5A1	hsa-miR-4709-3p	85.7477	NM_001278074
COL5A1	hsa-miR-6839-3p	85.4701	NM_001278074
COL5A1	hsa-miR-590-3p	85.1039	NM_000093
COL5A1	hsa-miR-939-3p	84.9664	NM_001278074
COL5A1	hsa-miR-135a-5p	84.6769	NM_000093
COL5A1	hsa-miR-135b-5p	84.6769	NM_000093
COL5A1	hsa-miR-9983-3p	84.338	NM_000093
COL5A1	hsa-miR-3188	84.283	NM_001278074
COL5A1	hsa-miR-5582-3p	84.2742	NM_001278074
COL5A1	hsa-miR-377-5p	83.4279	NM_000093
COL5A1	hsa-miR-5003-3p	83.4087	NM_000093
COL5A1	hsa-miR-607	83.3021	NM_001278074
COL5A1	hsa-miR-7160-5p	82.9837	NM_001278074
COL5A1	hsa-miR-7113-5p	82.8761	NM_001278074
COL5A1	hsa-miR-216a-3p	81.6436	NM_000093
COL5A1	hsa-miR-128-3p	81.6436	NM_000093
COL5A1	hsa-miR-627-3p	81.3237	NM_000093
COL5A1	hsa-miR-1297	80.5737	NM_000093

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Motifs and transcription factors (TFs) regulating COL5A1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
COL5A1	transfac_pro__M05770	ZNF77 (directAnnotation).
COL5A1	metacluster_22.37	BACH1 (directAnnotation).
COL5A1	tfdimers__MD00465	CRX; IKZF1 (directAnnotation).
COL5A1	transfac_pro__M06602	ZNF669 (directAnnotation).
COL5A1	tfdimers__MD00490	CDX2; SOX2 (directAnnotation).
COL5A1	jaspar__MA0079.5	SP1 (directAnnotation).
COL5A1	transfac_pro__M02896	SPI1 (inferredBy_Orthology).
COL5A1	transfac_pro__M05712	ZNF134 (directAnnotation).
COL5A1	transfac_pro__M07260	IKZF1 (directAnnotation).
COL5A1	hocomoco__PATZ1_HUMAN.H11MO.1.C	PATZ1 (directAnnotation).
COL5A1	swissregulon__hs__MTA3	MTA3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."