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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: COL4A1

Summary for COL4A1

Gene information	Gene symbol	COL4A1
	Ensembl ID	ENSG00000187498
	Entrez ID	1282
	Gene name	collagen type IV alpha 1 chain
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P02462

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Dataset with differentially expressed gene: COL4A1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.744471	1.77e-03
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.417897	0.00e+00

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Expression of COL4A1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to COL4A1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating COL4A1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
COL4A1	hsa-miR-190a-3p	99.9913	NM_001845
COL4A1	hsa-miR-5011-5p	99.9878	NM_001845
COL4A1	hsa-miR-5682	98.4654	NM_001845
COL4A1	hsa-miR-29a-3p	97.7447	NM_001845
COL4A1	hsa-miR-29c-3p	97.7447	NM_001845
COL4A1	hsa-miR-29b-3p	97.7447	NM_001845
COL4A1	hsa-miR-6871-3p	97.1946	NM_001845
COL4A1	hsa-miR-6732-3p	96.4727	NM_001845
COL4A1	hsa-miR-381-3p	96.1793	NM_001845
COL4A1	hsa-miR-300	96.1793	NM_001845
COL4A1	hsa-miR-488-3p	96.065	NM_001303110
COL4A1	hsa-miR-148b-3p	95.3492	NM_001845
COL4A1	hsa-miR-148a-3p	95.3492	NM_001845
COL4A1	hsa-miR-152-3p	95.3492	NM_001845
COL4A1	hsa-miR-345-3p	95.202	NM_001845
COL4A1	hsa-miR-3065-5p	95.1353	NM_001845
COL4A1	hsa-miR-4452	95.0722	NM_001845
COL4A1	hsa-miR-124-3p	94.8862	NM_001845
COL4A1	hsa-miR-506-3p	94.8862	NM_001845
COL4A1	hsa-let-7b-3p	94.7259	NM_001845
COL4A1	hsa-let-7f-1-3p	94.7259	NM_001845
COL4A1	hsa-let-7a-3p	94.7259	NM_001845
COL4A1	hsa-miR-98-3p	94.7259	NM_001845
COL4A1	hsa-miR-200b-5p	93.9759	NM_001303110
COL4A1	hsa-miR-200a-5p	93.9759	NM_001303110
COL4A1	hsa-miR-4659a-3p	93.7873	NM_001303110
COL4A1	hsa-miR-4659b-3p	93.7873	NM_001303110
COL4A1	hsa-miR-548bb-3p	93.7357	NM_001845
COL4A1	hsa-miR-548ac	93.7357	NM_001845
COL4A1	hsa-miR-548z	93.7357	NM_001845
COL4A1	hsa-miR-548d-3p	93.7357	NM_001845
COL4A1	hsa-miR-548h-3p	93.7357	NM_001845
COL4A1	hsa-miR-6768-3p	93.271	NM_001845
COL4A1	hsa-miR-10393-5p	92.8163	NM_001845
COL4A1	hsa-miR-6768-5p	92.6034	NM_001845
COL4A1	hsa-miR-466	92.1149	NM_001845
COL4A1	hsa-miR-23b-3p	91.6194	NM_001845
COL4A1	hsa-miR-23c	91.6194	NM_001845
COL4A1	hsa-miR-23a-3p	91.6194	NM_001845
COL4A1	hsa-miR-224-5p	91.2729	NM_001845
COL4A1	hsa-miR-10399-5p	91.1848	NM_001845
COL4A1	hsa-miR-6504-3p	91.1848	NM_001845
COL4A1	hsa-miR-548as-3p	90.5059	NM_001845
COL4A1	hsa-miR-4735-5p	90.4323	NM_001303110
COL4A1	hsa-miR-3152-3p	89.6839	NM_001845
COL4A1	hsa-miR-4500	89.5837	NM_001845
COL4A1	hsa-miR-8070	89.5282	NM_001845
COL4A1	hsa-miR-12131	89.4457	NM_001845
COL4A1	hsa-miR-1277-5p	89.4183	NM_001845
COL4A1	hsa-miR-524-5p	89.3565	NM_001845

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Motifs and transcription factors (TFs) regulating COL4A1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
COL4A1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
COL4A1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
COL4A1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
COL4A1	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
COL4A1	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
COL4A1	jaspar__MA1122.1	TFDP1 (directAnnotation).
COL4A1	transfac_pro__M04617	ZBTB7A (directAnnotation).
COL4A1	transfac_pro__M07387	ZBTB7A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."