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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: COL1A1

Summary for COL1A1

Gene information	Gene symbol	COL1A1
	Ensembl ID	ENSG00000108821
	Entrez ID	1277
	Gene name	collagen type I alpha 1 chain
	Synonyms	OI4
	Gene type	protein_coding
	UniProtAcc	P02452

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Dataset with differentially expressed gene: COL1A1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.884174	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.527973	4.37e-24
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.36641	1.84e-16
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.324437	6.21e-09
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.805936	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.309516	3.87e-05

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Expression of COL1A1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to COL1A1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
COL1A1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating COL1A1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
COL1A1	hsa-miR-29c-3p	98.2285	NM_000088
COL1A1	hsa-miR-29b-3p	98.2285	NM_000088
COL1A1	hsa-miR-29a-3p	98.2285	NM_000088
COL1A1	hsa-miR-5682	97.9939	NM_000088
COL1A1	hsa-miR-548aj-3p	97.812	NM_000088
COL1A1	hsa-miR-548x-3p	97.812	NM_000088
COL1A1	hsa-miR-548aq-3p	96.8223	NM_000088
COL1A1	hsa-miR-548ae-3p	96.8223	NM_000088
COL1A1	hsa-miR-548j-3p	96.3337	NM_000088
COL1A1	hsa-miR-548am-3p	96.3337	NM_000088
COL1A1	hsa-miR-548ah-3p	96.3337	NM_000088
COL1A1	hsa-miR-4789-5p	94.6342	NM_000088
COL1A1	hsa-miR-3148	94.5711	NM_000088
COL1A1	hsa-miR-5587-5p	93.3859	NM_000088
COL1A1	hsa-miR-9983-3p	91.7733	NM_000088
COL1A1	hsa-miR-92a-1-5p	91.4533	NM_000088
COL1A1	hsa-miR-6871-3p	91.0197	NM_000088
COL1A1	hsa-miR-7109-5p	90.88	NM_000088
COL1A1	hsa-miR-651-3p	90.5366	NM_000088
COL1A1	hsa-miR-129-5p	90.2108	NM_000088
COL1A1	hsa-miR-423-5p	89.8773	NM_000088
COL1A1	hsa-miR-3184-5p	89.8773	NM_000088
COL1A1	hsa-miR-372-5p	88.6449	NM_000088
COL1A1	hsa-miR-4789-3p	88.4173	NM_000088
COL1A1	hsa-miR-548av-3p	87.3592	NM_000088
COL1A1	hsa-miR-548ac	87.2682	NM_000088
COL1A1	hsa-miR-548z	87.2682	NM_000088
COL1A1	hsa-miR-548h-3p	87.2682	NM_000088
COL1A1	hsa-miR-6751-5p	86.9743	NM_000088
COL1A1	hsa-miR-6830-5p	85.6949	NM_000088
COL1A1	hsa-miR-548d-3p	85.3106	NM_000088
COL1A1	hsa-miR-548bb-3p	85.3106	NM_000088
COL1A1	hsa-miR-6734-5p	85.2182	NM_000088
COL1A1	hsa-miR-3613-3p	83.8162	NM_000088
COL1A1	hsa-miR-1275	83.5608	NM_000088
COL1A1	hsa-miR-4492	82.0568	NM_000088
COL1A1	hsa-miR-6803-5p	81.3973	NM_000088
COL1A1	hsa-miR-4507	81.2201	NM_000088
COL1A1	hsa-miR-3940-5p	81.2201	NM_000088
COL1A1	hsa-miR-4770	80.808	NM_000088
COL1A1	hsa-miR-143-3p	80.808	NM_000088
COL1A1	hsa-miR-6088	80.808	NM_000088
COL1A1	hsa-miR-561-5p	80.3759	NM_000088

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Motifs and transcription factors (TFs) regulating COL1A1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
COL1A1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
COL1A1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
COL1A1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
COL1A1	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
COL1A1	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
COL1A1	taipale_tf_pairs__CEBPG_ATF4_NNATGAYGCAAT_CAP	ATF4; CEBPG (directAnnotation).
COL1A1	transfac_pro__M06084	ZNF208 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
COL1A1	"Clove oil"	DB11338	biotech
COL1A1	"Collagenase clostridium histolyticum"	DB00048	biotech
COL1A1	"Halofuginone"	DB04866	small molecule
COL1A1	"Von Willebrand factor human"	DB13133	biotech
COL1A1	"Vonicog alfa"	DB12872	biotech

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."