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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CNTNAP2

Summary for CNTNAP2

Gene information	Gene symbol	CNTNAP2
	Ensembl ID	ENSG00000278728
	Entrez ID	26047
	Gene name	contactin associated protein 2
	Synonyms	Caspr2\|KIAA0868\|NRXN4
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CNTNAP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	3.95402	3.32e-03
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.296668	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.705966	0.00e+00

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Expression of CNTNAP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CNTNAP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CNTNAP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CNTNAP2	hsa-miR-5010-3p	99.6488	NM_014141
CNTNAP2	hsa-miR-651-5p	98.3726	NM_014141
CNTNAP2	hsa-miR-186-5p	98.0851	NM_014141
CNTNAP2	hsa-miR-4422	97.8729	NM_014141
CNTNAP2	hsa-miR-513c-5p	97.3513	NM_014141
CNTNAP2	hsa-miR-514b-5p	97.3513	NM_014141
CNTNAP2	hsa-miR-3145-3p	97.3207	NM_014141
CNTNAP2	hsa-miR-218-5p	97.2109	NM_014141
CNTNAP2	hsa-miR-587	97.0663	NM_014141
CNTNAP2	hsa-miR-5685	97.0209	NM_014141
CNTNAP2	hsa-miR-4690-3p	97.0209	NM_014141
CNTNAP2	hsa-miR-875-3p	96.8485	NM_014141
CNTNAP2	hsa-miR-5582-3p	96.3291	NM_014141
CNTNAP2	hsa-miR-3148	95.8252	NM_014141
CNTNAP2	hsa-miR-622	95.7564	NM_014141
CNTNAP2	hsa-miR-2113	94.9824	NM_014141
CNTNAP2	hsa-miR-9983-3p	94.4019	NM_014141
CNTNAP2	hsa-miR-10527-5p	93.9383	NM_014141
CNTNAP2	hsa-miR-8485	93.3711	NM_014141
CNTNAP2	hsa-miR-3128	93.3516	NM_014141
CNTNAP2	hsa-miR-576-5p	93.2939	NM_014141
CNTNAP2	hsa-miR-548ar-3p	92.5882	NM_014141
CNTNAP2	hsa-miR-3133	92.4166	NM_014141
CNTNAP2	hsa-miR-129-5p	91.6905	NM_014141
CNTNAP2	hsa-miR-6077	91.3807	NM_014141
CNTNAP2	hsa-miR-548p	91.2531	NM_014141
CNTNAP2	hsa-miR-149-5p	90.8857	NM_014141
CNTNAP2	hsa-miR-548f-3p	90.2629	NM_014141
CNTNAP2	hsa-miR-548a-3p	90.2629	NM_014141
CNTNAP2	hsa-miR-548e-3p	90.2629	NM_014141
CNTNAP2	hsa-miR-548bc	90.2629	NM_014141
CNTNAP2	hsa-miR-548az-3p	90.2629	NM_014141
CNTNAP2	hsa-miR-1299	89.8634	NM_014141
CNTNAP2	hsa-miR-6749-3p	89.8588	NM_014141
CNTNAP2	hsa-miR-5088-5p	89.798	NM_014141
CNTNAP2	hsa-miR-513a-5p	89.4513	NM_014141
CNTNAP2	hsa-miR-548aj-3p	89.4482	NM_014141
CNTNAP2	hsa-miR-548x-3p	89.4482	NM_014141
CNTNAP2	hsa-miR-6885-3p	89.2728	NM_014141
CNTNAP2	hsa-miR-3617-5p	88.5264	NM_014141
CNTNAP2	hsa-miR-641	88.5264	NM_014141
CNTNAP2	hsa-miR-8075	88.1307	NM_014141
CNTNAP2	hsa-miR-7856-5p	87.8279	NM_014141
CNTNAP2	hsa-miR-3126-3p	86.9595	NM_014141
CNTNAP2	hsa-miR-599	86.771	NM_014141
CNTNAP2	hsa-miR-4999-5p	86.3157	NM_014141
CNTNAP2	hsa-miR-153-5p	85.8475	NM_014141
CNTNAP2	hsa-miR-6868-3p	85.8432	NM_014141
CNTNAP2	hsa-miR-6132	85.3163	NM_014141
CNTNAP2	hsa-miR-6836-5p	85.3163	NM_014141

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Motifs and transcription factors (TFs) regulating CNTNAP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CNTNAP2	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
CNTNAP2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
CNTNAP2	transfac_pro__M04950	EGR1 (directAnnotation).
CNTNAP2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CNTNAP2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
CNTNAP2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
CNTNAP2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
CNTNAP2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CNTNAP2	transfac_pro__M00652	NRF1 (directAnnotation).
CNTNAP2	hdpi__ETV4	ETV4 (directAnnotation).
CNTNAP2	transfac_pro__M04866	HDAC2 (directAnnotation).
CNTNAP2	jaspar__MA1122.1	TFDP1 (directAnnotation).
CNTNAP2	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
CNTNAP2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
CNTNAP2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CNTNAP2	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
CNTNAP2	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
CNTNAP2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
CNTNAP2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
CNTNAP2	transfac_pro__M04617	ZBTB7A (directAnnotation).
CNTNAP2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CNTNAP2	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
CNTNAP2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CNTNAP2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CNTNAP2	transfac_pro__M07387	ZBTB7A (directAnnotation).
CNTNAP2	transfac_pro__M07436	WT1 (directAnnotation).
CNTNAP2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CNTNAP2	transfac_pro__M00716	ZBTB14 (directAnnotation).
CNTNAP2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CNTNAP2	hdpi__HIP2	UBE2K (directAnnotation).
CNTNAP2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CNTNAP2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CNTNAP2	transfac_pro__M04893	TAF1 (directAnnotation).
CNTNAP2	transfac_pro__M03876	ZBTB33 (directAnnotation).
CNTNAP2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CNTNAP2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CNTNAP2	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
CNTNAP2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CNTNAP2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CNTNAP2	jaspar__MA1483.2	ELF2 (directAnnotation).
CNTNAP2	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
CNTNAP2	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
CNTNAP2	swissregulon__hs__ETV6	ETV6 (directAnnotation).
CNTNAP2	cisbp__M02645	ETS1 (directAnnotation).
CNTNAP2	cisbp__M08198	ELF1 (directAnnotation).
CNTNAP2	jaspar__MA1708.1	ETV7 (directAnnotation).
CNTNAP2	dbtfbs__ZNF121_HEK293_ENCSR224QDY_merged_N3	ZNF121 (directAnnotation).
CNTNAP2	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
CNTNAP2	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."