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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CNTN4

Summary for CNTN4

Gene information	Gene symbol	CNTN4
	Ensembl ID	ENSG00000144619
	Entrez ID	152330
	Gene name	contactin 4
	Synonyms	BIG-2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CNTN4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.413862	5.94e-03

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Expression of CNTN4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CNTN4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CNTN4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CNTN4	hsa-miR-656-3p	99.1371	NM_001206955
CNTN4	hsa-miR-5011-5p	98.5614	NM_001206955
CNTN4	hsa-miR-548p	98.4265	NM_001206955
CNTN4	hsa-miR-10399-5p	98.1054	NM_001206955
CNTN4	hsa-miR-6504-3p	98.1054	NM_001206955
CNTN4	hsa-miR-548g-3p	97.1269	NM_001206955
CNTN4	hsa-miR-10527-5p	97.0644	NM_001206955
CNTN4	hsa-miR-153-5p	96.9475	NM_001206955
CNTN4	hsa-miR-607	94.6242	NM_001206955
CNTN4	hsa-miR-548av-3p	94.5474	NM_001206955
CNTN4	hsa-miR-338-5p	94.5232	NM_001206955
CNTN4	hsa-miR-888-3p	93.977	NM_001206955
CNTN4	hsa-miR-653-5p	93.8894	NM_001206955
CNTN4	hsa-miR-4262	93.8409	NM_001206955
CNTN4	hsa-miR-1183	93.0245	NM_001206955
CNTN4	hsa-miR-5580-3p	92.9093	NM_001206955
CNTN4	hsa-miR-9983-3p	92.5201	NM_001206955
CNTN4	hsa-miR-181d-5p	92.4449	NM_001206955
CNTN4	hsa-miR-181b-5p	92.4449	NM_001206955
CNTN4	hsa-miR-181a-5p	92.4449	NM_001206955
CNTN4	hsa-miR-181c-5p	92.4449	NM_001206955
CNTN4	hsa-miR-129-5p	91.9243	NM_001206955
CNTN4	hsa-miR-5701	91.4495	NM_001206955
CNTN4	hsa-miR-4422	91.3394	NM_001206955
CNTN4	hsa-miR-16-2-3p	90.8362	NM_001206955
CNTN4	hsa-miR-195-3p	90.8362	NM_001206955
CNTN4	hsa-miR-8080	89.6006	NM_001206955
CNTN4	hsa-miR-196a-1-3p	89.5863	NM_001206955
CNTN4	hsa-miR-1278	89.5423	NM_001206955
CNTN4	hsa-miR-1261	89.4312	NM_001206955
CNTN4	hsa-miR-548e-3p	89.2457	NM_001206955
CNTN4	hsa-miR-548az-3p	89.2457	NM_001206955
CNTN4	hsa-miR-548bc	89.2457	NM_001206955
CNTN4	hsa-miR-548a-3p	89.2457	NM_001206955
CNTN4	hsa-miR-548f-3p	89.2457	NM_001206955
CNTN4	hsa-miR-548ar-3p	89.2378	NM_001206955
CNTN4	hsa-miR-651-3p	88.8337	NM_001206955
CNTN4	hsa-miR-4653-5p	88.7527	NM_001206955
CNTN4	hsa-miR-3921	88.7527	NM_001206955
CNTN4	hsa-miR-380-3p	88.4418	NM_001206955
CNTN4	hsa-miR-5584-3p	88.3251	NM_001206955
CNTN4	hsa-miR-152-3p	88.0594	NM_001206955
CNTN4	hsa-miR-148a-3p	88.0594	NM_001206955
CNTN4	hsa-miR-148b-3p	88.0594	NM_001206955
CNTN4	hsa-miR-4661-5p	87.706	NM_001206955
CNTN4	hsa-miR-1250-3p	87.2781	NM_001206955
CNTN4	hsa-miR-3915	87.1714	NM_001206955
CNTN4	hsa-miR-3680-3p	87.0937	NM_001206955
CNTN4	hsa-miR-208b-5p	87.0435	NM_001206955
CNTN4	hsa-miR-4251	87.0388	NM_001206955

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Motifs and transcription factors (TFs) regulating CNTN4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."