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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CNST

Summary for CNST

Gene information	Gene symbol	CNST
	Ensembl ID	ENSG00000162852
	Entrez ID	163882
	Gene name	consortin, connexin sorting protein
	Synonyms	C1orf71\|FLJ32001\|PPP1R64
	Gene type	protein_coding
	UniProtAcc	Q6PJW8

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Dataset with differentially expressed gene: CNST

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.28559	7.22e-08

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Expression of CNST in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CNST

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CNST

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CNST	hsa-miR-4799-5p	99.8245	NM_152609
CNST	hsa-miR-582-5p	97.139	NM_152609
CNST	hsa-miR-548aj-3p	97.0613	NM_152609
CNST	hsa-miR-548x-3p	97.0613	NM_152609
CNST	hsa-miR-3671	96.5354	NM_152609
CNST	hsa-miR-548am-3p	96.4065	NM_152609
CNST	hsa-miR-548ae-3p	96.4065	NM_152609
CNST	hsa-miR-548aq-3p	96.4065	NM_152609
CNST	hsa-miR-548j-3p	96.4065	NM_152609
CNST	hsa-miR-548ah-3p	96.4065	NM_152609
CNST	hsa-miR-190b-3p	96.1178	NM_152609
CNST	hsa-miR-106a-3p	95.6632	NM_001139459
CNST	hsa-miR-4282	93.1114	NM_152609
CNST	hsa-miR-708-3p	91.9885	NM_152609
CNST	hsa-miR-5692a	91.8877	NM_152609
CNST	hsa-miR-4277	90.9878	NM_152609
CNST	hsa-miR-30d-5p	89.031	NM_152609
CNST	hsa-miR-30b-5p	89.031	NM_152609
CNST	hsa-miR-30a-5p	89.031	NM_152609
CNST	hsa-miR-30e-5p	89.031	NM_152609
CNST	hsa-miR-30c-5p	89.031	NM_152609
CNST	hsa-miR-606	88.7309	NM_001139459
CNST	hsa-miR-4760-3p	88.429	NM_152609
CNST	hsa-miR-4307	88.3015	NM_001139459
CNST	hsa-miR-10399-5p	87.9728	NM_152609
CNST	hsa-miR-6504-3p	87.9728	NM_152609
CNST	hsa-miR-607	87.9225	NM_152609
CNST	hsa-miR-497-3p	87.0811	NM_152609
CNST	hsa-miR-6768-5p	86.8521	NM_152609
CNST	hsa-miR-3152-5p	86.2779	NM_152609
CNST	hsa-miR-4329	86.0352	NM_152609
CNST	hsa-miR-513a-3p	85.5918	NM_152609
CNST	hsa-miR-513c-3p	85.5918	NM_152609
CNST	hsa-miR-16-1-3p	85.2705	NM_152609
CNST	hsa-miR-3606-3p	84.6611	NM_152609
CNST	hsa-miR-3194-5p	84.6118	NM_152609
CNST	hsa-miR-10393-5p	83.9609	NM_152609
CNST	hsa-miR-6731-3p	83.2857	NM_152609
CNST	hsa-miR-3972	82.9102	NM_152609
CNST	hsa-miR-6885-3p	82.4377	NM_152609
CNST	hsa-miR-6894-3p	82.2236	NM_152609
CNST	hsa-miR-1202	81.7478	NM_152609
CNST	hsa-miR-6828-3p	81.5856	NM_152609
CNST	hsa-miR-5698	81.2593	NM_152609
CNST	hsa-miR-6870-5p	81.2593	NM_152609
CNST	hsa-miR-7111-5p	81.2593	NM_152609
CNST	hsa-miR-4723-5p	81.2593	NM_152609

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Motifs and transcription factors (TFs) regulating CNST

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CNST	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
CNST	transfac_pro__M01783	SP2 (directAnnotation).
CNST	cisbp__M00341	PAX6 (directAnnotation).
CNST	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CNST	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
CNST	cisbp__M00968	MTF2 (directAnnotation).
CNST	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
CNST	jaspar__MA0748.2	YY2 (directAnnotation).
CNST	taipale_tf_pairs__ERF_PITX1_NSCGGANNNNNNGGMTTA_CAP	ERF; PITX1 (directAnnotation).
CNST	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."