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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CNPPD1

Summary for CNPPD1

Gene information	Gene symbol	CNPPD1
	Ensembl ID	ENSG00000115649
	Entrez ID	27013
	Gene name	cyclin Pas1/PHO80 domain containing 1
	Synonyms	C2orf24\|CGI-57
	Gene type	protein_coding
	UniProtAcc	Q9BV87

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Dataset with differentially expressed gene: CNPPD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	cDCs	0.283033	1.51e-06
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.320617	0.00e+00

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Expression of CNPPD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CNPPD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CNPPD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CNPPD1	hsa-miR-7-5p	94.3931	NM_001321389
CNPPD1	hsa-miR-452-5p	90.2003	NM_001321390
CNPPD1	hsa-miR-4676-3p	90.2003	NM_001321390
CNPPD1	hsa-miR-892c-3p	90.2003	NM_001321390
CNPPD1	hsa-miR-7851-3p	88.4656	NM_001321390
CNPPD1	hsa-miR-6077	88.321	NM_001321389
CNPPD1	hsa-miR-4277	83.814	NM_001321390
CNPPD1	hsa-miR-1283	82.5924	NM_001321390
CNPPD1	hsa-miR-6732-3p	80.2792	NM_001321390

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Motifs and transcription factors (TFs) regulating CNPPD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CNPPD1	metacluster_155.21	ZNF454; ZNF454 (directAnnotation).
CNPPD1	metacluster_127.3	FOXO1; FOXO3; FOXO4 (directAnnotation).
CNPPD1	transfac_pro__M01968	FOXO1 (directAnnotation).
CNPPD1	taipale_tf_pairs__ELK1_FOXI1_RSCGGAANRTMAAYA_CAP_repr	ELK1; FOXI1 (directAnnotation).
CNPPD1	kznf__ZNF334_Imbeault2017_OM_MEME	ZNF334 (directAnnotation).
CNPPD1	swissregulon__hs__ZKSCAN3	ZKSCAN3 (directAnnotation).
CNPPD1	metacluster_130.9	ZNF569 (directAnnotation). ZNF569 (inferredBy_Orthology).
CNPPD1	hocomoco__FOXP1_HUMAN.H11MO.0.A	FOXP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."